The obtained results provide a support for the use of this plant in traditional medicine but further pharmacological studies are required.

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phenol and total flavonoid content determination assays. The antimicrobial assay was performed by disc diffusion method using kanamycin and Nystatin as the standard. Results: The most prominent antioxidant activity was observed with PLPE in DPPH radical scavenging test (IC 50 =191.308 ± 28.450 µg/ml) as opposed to that of standard ascorbic acid (IC 50 = 43.129 ± 1.181µg/ml). In total antioxidant capacity method, FHCE showed the highest activity (837.558 ± 110.835 mg ascorbic acid/g). The total phenolic and flavonoids content were determined by Folin-Ciocalteu Reagent and aluminum chloride colorimetric method respectively. The highest total phenols & total flavonoids content were found in VNPE (180.434 ± 142.19 mg Gallic acid/g & 1265.255 ± 165.593 mg quercetin/g, respectively). The ferric reducing capacity of the extracts was strong and dose dependent manner. PLPE displayed the highest antimicrobial actions against Bacillus megaterium (40 mm). Conclusion: Comparison of different plant extracts used in the present study in various tested models showed wide variations in phenolic content and varying degrees of radical scavenging & reducing capacity. The obtained results indicate that investigated plants could be potential sources of natural antioxidants & antimicrobial agents and can be used for infectious diseases.

A simple, selective and rapid reversed phase high performance liquid chromatographic (RPHPLC) method for the analysis of Ciclesonide has been developed and validated. The separation was achieved from HPLC Column (Waters Symmetry C18 5 µ; 4.6 mm x 250 mm) with a mobile phase consisting of 85 volume of Ethanol with 15 volume of Millie-Q-Water at a flow rate of 1.10 ml/min with UV detection at 242 nm. The method is specific and it is observed that no interference with diluents. The proposed method is accurate with 99.6 % recovery for Ciclesonide and precise (% RSD of area of system precision, % RSD of assay of method precision and Intermediate precision are found to be 0.20 %, 0.20 % and 0.20 % respectively). From the linearity study the correlation coefficient is found to be 0.9999, which indicates that the method is linear over 10 % to 150 % range. The method is found robust for possible changes. Therefore, this method can be used as a more convenient and efficient option for the analysis of Ciclesonide to establish the quality of the drug substance during routine analysis with consistent and reproducible results

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