Pi-class glutathione S-transferase: regulation and function

Henderson, Colin J.; McLaren, Aileen; Moffat, Graeme J.; Bacon, E J; Wolf, C. Roland

doi:10.1016/s0009-2797(97)00176-2

Cited by 110 publications

(70 citation statements)

References 20 publications

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“…We found GSTP1 methylation to correlate strongly with increasing tumor size and a greater likelihood of SLN metastasis. This finding is important as GSTs are a family of enzymes that detoxify hydrophobic electrophiles, which include carcinogens that have been implicated in a variety of cancers (27). Because diet has been implicated in breast cancer (28), GSTP1 loss may result in impaired cellular defenses leading to increasing genome damage and cancer progression (29).…”

Section: Discussionmentioning

confidence: 99%

Distinct Hypermethylation Profile of Primary Breast Cancer Is Associated with Sentinel Lymph Node Metastasis

Shinozaki

Hoon

Giuliano

et al. 2005

Clinical Cancer Research

152

132

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Purpose: Gene promoter region hypermethylation is a significant event in primary breast cancer. However, its impact on tumor progression and potential predictive implications remain relatively unknown.Experimental Design: We conducted hypermethylation profiling of 151 primary breast tumors with association to known prognostic factors in breast cancer using methylationspecific PCR for six known tumor suppressor and related genes: RASSF1A, APC, TWIST, CDH1, GSTP1, and RAR-B B2. Furthermore, correlation with sentinel lymph node (SLN) tumor status was assessed as it represents the earliest stage of metastasis that is readily detected. Hypermethylation for any one gene was identified in 147 (97%) of 151 primary breast tumors. The most frequently hypermethylated gene was RASSF1A (81%).Results: Hypermethylation of the CDH1 was significantly associated with primary breast tumors demonstrating lymphovascular invasion (P = 0.008), infiltrating ductal histology (P = 0.03), and negative for the estrogen receptor (P = 0.005), whereas RASSF1A and RAR-B B2 gene hypermethylation were significantly more common in estrogen receptor -positive (P < 0.001) and human epidermal growth factor receptor 2 -positive (P < 0.001) tumors, respectively. In multivariate analysis, hypermethylation of GSTP1 and/or RAR-B B2 was significantly associated with patients having macroscopic SLN metastasis compared with those with microscopic or no sentinel node metastasis (odds ratio, 4.59; 95% confidence interval, 2.02-10.4; P < 0.001). In paired SLN metastasis, CDH1 was the most frequently methylated gene (90%) and provides evidence in patients corroborating its role in the clinical development of metastasis.Conclusion: Hypermethylation profiling of primary breast tumors is significantly associated with known pathologic prognostic factors and may have additional clinical and pathologic utility for assessing patient prognosis and predicting early regional metastasis.

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Section: Discussionmentioning

confidence: 99%

Distinct Hypermethylation Profile of Primary Breast Cancer Is Associated with Sentinel Lymph Node Metastasis

Shinozaki

Hoon

Giuliano

et al. 2005

Clinical Cancer Research

152

132

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“…GSTP1 is a caretaker gene as it detoxifies endogeneous and exogeneous toxic compounds and thus protects the organism against genome damage, oxidative stress (Hayes & Strange, 1995), cancer (Henderson et al, 1998), and degenerative diseases (Guven et al, 2011). Downregulation of GSTP1 expression with concomitant decrease of detoxification is a common precancerous event (Cookson et al, 1997;Meiers et al, 2007;Song et al, 2002) while its upregulation at the later stages of tumor development causes multidrug resistance (Diah et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…In this study we focused on the functional role of cis-elements of GSTP1 promoter and corresponding transcription factors in regulation of gene transcription in human malignant melanoma cells. The interaction of cis-elements of GSTP1 promoter with transcription factors were examined in different malignant cells (Duvoix et al, 2003;Henderson et al, 1998;Jhaveri & Morrow, 1998). All these studies have shown that in different kind of cells cell-specific transcription factors bind the same response elements.…”

Section: Discussionmentioning

confidence: 99%

“…However, mutations are not the single cause of GSTP1 insufficiency. This phenomenon occurs in different tumors as a result of GSTP1 gene repression by methylation of promoter or via specific set of transcription factors (Henderson et al, 1998). Unlike down-regulation of GSTP1 expression its overexpression is associated with the development of multidrug resistance (Harbottle et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Regulation of the Glutathione S-Transferase P1 Expression in Melanoma Cells

Slonchak¹,

Chwieduk²,

Rzeszowska-Wolny³

et al. 2011

Breakthroughs in Melanoma Research

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“…231 In addition, these enzymes play a role in the protection of DNA from oxidative damage. 232 Using methylation-specific PCR, Goessl et al 233 found that in 26 patients undergoing prostate biopsies for clinically suspected PC, all 10 patients diagnosed with adenocarcinoma (100%) and four of six patients with PIN (67%), but none of 10 patients with BPH (0%), exhibited GSTP1 promoter hypermethylation.…”

Section: 'Suppression Of Tumorigenicity 7' Tsgmentioning

confidence: 99%

Molecular biology of prostate cancer

Karayi

Markham

2004

Prostate Cancer Prostatic Dis

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Development of any cancer reflects a progressive accumulation of alterations in various genes. Oncogenes, tumour suppressor genes, DNA repair genes and metastasis suppressor genes have been investigated in prostate cancer. Here, we review current understanding of the molecular biology of prostate cancer. Detailed understanding of the molecular basis of prostate cancer will provide insights into the aetiology and prognosis of the disease, and suggest avenues for therapeutic intervention in the future.

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Pi-class glutathione S-transferase: regulation and function

Cited by 110 publications

References 20 publications

Distinct Hypermethylation Profile of Primary Breast Cancer Is Associated with Sentinel Lymph Node Metastasis

Distinct Hypermethylation Profile of Primary Breast Cancer Is Associated with Sentinel Lymph Node Metastasis

Regulation of the Glutathione S-Transferase P1 Expression in Melanoma Cells

Molecular biology of prostate cancer

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