Piezoelectric polymer membranes with thin antibacterial coating for the regeneration of oral mucosa

Badaraev, Arsalan D.; Коняева, А. Д.; Krikova, S.A.; Shesterikov, E. V.; Bolbasov, E. N.; Nemoykina, Anna L.; Bouznik, V. M.; Stankevich, Ksenia S.; Zhukov, Yu. M.; Мишин, И. П.; Varakuta, E. Yu.; Tverdokhlebov, Sergei I.

doi:10.1016/j.apsusc.2019.144068

Cited by 31 publications

(22 citation statements)

References 49 publications

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“…The presence of the β phase indicates ferroelectric and piezoelectric properties in the produced polymer membranes [ 29 ]. The formation of electrically active crystalline phases in electrospun non-woven materials based on polyvinylidene fluoride and its copolymers is caused by the polarization of the polymer under the influence of a high-intensity electric field in the space between the needle and the collector [ 30 ]. Unlike the DLC coatings deposited using the reactive magnetron sputtering method, the coatings obtained using the pulsed vacuum arc deposition technique were found to be amorphous regardless of the capacitor storage voltage.…”

Section: Resultsmentioning

confidence: 99%

DLC-Coated Ferroelectric Membranes as Vascular Patches: Physico-Chemical Properties and Biocompatibility

et al. 2021

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In this paper, the results on the fabrication of ferroelectric membranes as vascular patches with modified surfaces are presented. For the modification of a membrane surface contacting blood, DLC coating was deposited using the pulsed vacuum arc deposition technique. The physico-chemical properties and cytotoxicity of the membranes modified under various conditions were studied. It was found that DLC coatings do not affect membrane microstructure, preserving its crystal structure as well as its high strength and elongation. It was revealed that an increase in the capacitor storage voltage results in the rise in sp2- and sp-hybridized carbon concentration, which makes it possible to control the chemical structure and surface energy of the modified surface. The experiments with 3T3L1 fibroblasts showed no toxic effects of the materials extracts.

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Section: Resultsmentioning

confidence: 99%

DLC-Coated Ferroelectric Membranes as Vascular Patches: Physico-Chemical Properties and Biocompatibility

et al. 2021

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“…Примером таких покрытий является полимерная мембрана на основе сополимера винилиденфторида с тетрафторэтиленом (VDF-TeFE) сформированная методом электроформования в лаборатории гибридных биоматериалов Томского политехнического университета. Обладая пьезоэлектрическими свойствами, она не только защищает раневой дефект от внешних воздействий, но и способствует стимуляции регенеративных процессов, а также является инертной по отношению к организму [7,8].…”

Section: Introductionunclassified

Morphofunctional Changes in Oral Mucosa Vessels when Healing a Wound Defect Using a Polymer Membrane

2021

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This works aims to study morphofunctional changes in the vessels of the oral mucosa during regeneration of a wound defect with and without a polymer membrane.An experiment was carried out on 35 white Wistar rats divided into three groups: control, experimental 1 and experimental 2. To form a wound defect, a ﬂap of the oral mucosa was excised, which was covered by a polymeric piezoelectric membrane in the rats of group 2. Histological examination was carried out on the 3rd, 7th and 12th days: the control material was taken, histological preparations were made according to the standard method. In the lesion focus and surrounding tissues, speciﬁc areas and numerical densities of arterioles, venules and capillaries were determined; the pericapillary diffusion index, Kernogan index and arterio-venular ratio were calculated.On the 3rd day, all indicators in all experimental groups did not signiﬁcantly differ from each other, but had signiﬁcant differences from the control group. On the 7th day of the study, in the 1st group, the numerical density of open arterioles and venules corresponded to the control group. In group 2, the numerical density of capillaries and altered venules, as well as the index of pericapillary diffusion, signiﬁcantly differed from the control. On the 12th day of the study, the numerical density of open venules reached control values in the uncoated group. In the 2nd group, all indicators corresponded to the control values.Protection of the wound defect from microbial contamination and re-traumatization, the presence of piezoelectric properties of the membrane under study contributed to a more effective restoration of vessels. This conﬁrms the efﬁcacy of the membrane under study when used as a wound covering.

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“…Due to the higher electronegativity of fluorine (F) compared to carbon (C) and hydrogen (H) in polyvinylidene fluoride (PVDF), which is the most electrically active piezoelectric polymer [ 12 ], and its copolymers with tetra-(TeFE) and trifluoroethylene (TrFE), a certain conformation of macromolecules results in a dipole moment in a polymer chain directed perpendicular to its axis. Currently, the application of PVDF elecrospun scaffolds as a wound healing material is being actively studied [ 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Composite Ferroelectric Membranes Based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healing

et al. 2020

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Wound healing is a complex process and an ongoing challenge for modern medicine. Herein, we present the results of study of structure and properties of ferroelectric composite polymer membranes for wound healing. Membranes were fabricated by electrospinning from a solution of vinylidene fluoride/tetrafluoroethylene copolymer (VDF–TeFE) and polyvinylpyrrolidone (PVP) in dimethylformamide (DMF). The effects of the PVP content on the viscosity and conductivity of the spinning solution, DMF concentration, chemical composition, crystal structure, and conformation of VDF–TeFE macromolecules in the fabricated materials were studied. It was found that as PVP amount increased, the viscosity and conductivity of the spinning solutions decreased, resulting in thinner fibers. Using FTIR and XRD methods, it was shown that if the PVP content was lower than 50 wt %, the VDF–TeFE copolymer adopted a flat zigzag conformation (TTT conformation) and crystalline phases with ferroelectric properties were formed. Gas chromatography results indicated that an increase in the PVP concentration led to a higher residual amount of DMF in the material, causing cytotoxic effects on 3T3L1 fibroblasts. In vivo studies demonstrated that compared to classical gauze dressings impregnated with a solution of an antibacterial agent, ferroelectric composite membranes with 15 wt % PVP provided better conditions for the healing of purulent wounds.

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Piezoelectric polymer membranes with thin antibacterial coating for the regeneration of oral mucosa

Cited by 31 publications

References 49 publications

DLC-Coated Ferroelectric Membranes as Vascular Patches: Physico-Chemical Properties and Biocompatibility

DLC-Coated Ferroelectric Membranes as Vascular Patches: Physico-Chemical Properties and Biocompatibility

Morphofunctional Changes in Oral Mucosa Vessels when Healing a Wound Defect Using a Polymer Membrane

Composite Ferroelectric Membranes Based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healing

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