Pilot Study of Renal Diffusion Tensor Imaging as a Correlate to Histopathology in Pediatric Renal Allografts

Li, Yang; Lee, Marsha M.; Worters, Pauline W.; MacKenzie, J. D.; Lászik, Zoltán; Courtier, Jesse

doi:10.2214/ajr.16.17418

Cited by 20 publications

(19 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[68][69][70][71] In fibrotic kidneys, the diffuse interstitial fibrosis as well as tubular atrophy, cell infiltration, and glomerular scarring may also alter water diffusion and correlate well with renal FA in both animal models 72,73 and humans. 36,69,74,75…”

Section: Diffusion Tensor Imagingmentioning

confidence: 99%

Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques

Jiang

Ferguson

Lerman

2019

Translational Research

View full text Add to dashboard Cite

Renal fibrosis is a useful biomarker for diagnosis and guidance of therapeutic interventions of chronic kidney disease (CKD), a worldwide disease that affects more than 10% of the population and is one of the major causes of death. Currently, tissue biopsy is the gold standard for assessment of renal fibrosis. However, it is invasive, and prone to sampling error and observer variability, and may also result in complications. Recent advances in diagnostic imaging techniques, including magnetic resonance imaging (MRI) and ultrasonography, have shown promise for noninvasive assessment of renal fibrosis. These imaging techniques measure renal fibrosis by evaluating its impacts on the functional, mechanical, and molecular properties of the kidney, such as water mobility by diffusion MRI, tissue hypoxia by blood oxygenation level dependent MRI, renal stiffness by MR and ultrasound elastography, and macromolecule content by magnetization transfer imaging. Other MR techniques, such as T 1 /T 2 mapping and susceptibility-weighted imaging have also been explored for measuring renal fibrosis. Promising findings have been reported in both preclinical and clinical studies using these techniques. Nevertheless, limited specificity, sensitivity, and practicality in these techniques may hinder their immediate application in clinical routine. In this review, we will introduce methodologies of these techniques, outline their applications in fibrosis imaging, and discuss their limitations and pitfalls.

show abstract

Section: Diffusion Tensor Imagingmentioning

confidence: 99%

Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques

Jiang

Ferguson

Lerman

2019

Translational Research

View full text Add to dashboard Cite

show abstract

“…Li et al utilized the Kendall tau correlation coefficient and found that medullary FA values were inversely correlated with histopathology scores, such as tubulitis, interstitial inflammation, tubular atrophy, and interstitial fibrosis. Concomitantly, cortical FA values show an inverse correlation with peritubular capolaritis . Using a b value of 800 s/mm 2 , medullary FA values can even potentially determine whether pediatric renal allograft recipients need a change in their clinical management.…”

Section: Applications Of Renal Fmrimentioning

confidence: 99%

Renal Functional MRI and Its Application

Zhou

Wang

Zeng

et al. 2018

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…22 A recent study on pediatric renal allografts has shown a moderate correlation of medullary FA with several Banff histopathology scores (particularly at higher b-values) but not cortical FA. 34 Neither cortical nor medullary FA correlated with the glomerulitis (g) Banff score. This suggests that more specific biomarkers of renal microstructure are desirable.…”

Section: Introductionmentioning

confidence: 98%

“…However, FA remains unable to differentiate between different pathophysiological mechanisms underlying renal dysfunction . A recent study on pediatric renal allografts has shown a moderate correlation of medullary FA with several Banff histopathology scores (particularly at higher b‐values) but not cortical FA . Neither cortical nor medullary FA correlated with the glomerulitis (g) Banff score.…”

Section: Introductionmentioning

confidence: 99%

In vivo demonstration of microscopic anisotropy in the human kidney using multidimensional diffusion MRI

Nery

Szczepankiewicz

Kerkelä

et al. 2019

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose To demonstrate the feasibility of multidimensional diffusion MRI to probe and quantify microscopic fractional anisotropy (µFA) in human kidneys in vivo. Methods Linear tensor encoded (LTE) and spherical tensor encoded (STE) renal diffusion MRI scans were performed in 10 healthy volunteers. Respiratory triggering and image registration were used to minimize motion artefacts during the acquisition. Kidney cortex–medulla were semi‐automatically segmented based on fractional anisotropy (FA) values. A model‐free analysis of LTE and STE signal dependence on b‐value in the renal cortex and medulla was performed. Subsequently, µFA was estimated using a single‐shell approach. Finally, a comparison of conventional FA and µFA is shown. Results The hallmark effect of µFA (divergence of LTE and STE signal with increasing b‐value) was observed in all subjects. A statistically significant difference between LTE and STE signal was found in the cortex and medulla, starting from b = 750 s/mm2 and b = 500 s/mm2, respectively. This difference was maximal at the highest b‐value sampled (b = 1000 s/mm2) which suggests that relatively high b‐values are required for µFA mapping in the kidney compared to conventional FA. Cortical and medullary µFA were, respectively, 0.53 ± 0.09 and 0.65 ± 0.05, both respectively higher than conventional FA (0.19 ± 0.02 and 0.40 ± 0.02). Conclusion The feasibility of combining LTE and STE diffusion MRI to probe and quantify µFA in human kidneys is demonstrated for the first time. By doing so, we show that novel microstructure information—not accessible by conventional diffusion encoding—can be probed by multidimensional diffusion MRI. We also identify relevant technical limitations that warrant further development of the technique for body MRI.

show abstract

Pilot Study of Renal Diffusion Tensor Imaging as a Correlate to Histopathology in Pediatric Renal Allografts

Abstract: FA is a noninvasive correlate of several important renal allograft histopathology scores and a potential noninvasive method of assessing renal allograft health in pediatric allograft recipients.

Cited by 20 publications

References 29 publications

Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques

Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques

Renal Functional MRI and Its Application

In vivo demonstration of microscopic anisotropy in the human kidney using multidimensional diffusion MRI

Contact Info

Product

Resources

About