Piper umbellatum L.: A medicinal plant with gastric-ulcer protective and ulcer healing effects in experimental rodent models

Silva, Iberê Ferreira da; Balogun, Sikiru Olaitan; Oliveira, Ruberlei Godinho de; Damazo, Amílcar Sabino; Martins, Domingos Tabajara de Oliveira

doi:10.1016/j.jep.2016.07.011

Cited by 43 publications

(15 citation statements)

References 44 publications

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“…Diclofenac sodium administration resulted in a significant increase in MDA level, whereas CAT activity and GSH content were markedly reduced in stomach tissue in comparison with the negative control rats. CAT and GSH are fundamental antioxidants that afford protection to gastric tissue against ROS (Da Silva Junior, Balogun, De Oliveira, Damazo, & Martins, ). CAT can protect gastric mucosa from free radicals by reducing H 2 O 2 and converting it to water and molecular oxygen (Panneerselvam & Arumugam, ).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

et al. 2017

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This study was designed to investigate the antioxidant and antiulcer activities of flavonoid‐rich fractions of Zingiber officinale extract. The fractions, obtained by solvents of increasing polarities, were subjected to 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activity. The fraction which possessed the highest antioxidant activity was used to assess gastroprotective action against diclofenac sodium induced gastric ulcer in rats. Chromatographic profiling was carried out using LC‐ESI‐MS analysis. The butanol fraction (BF) showed the strongest antioxidant potential and the results of the in vivo study revealed that BF at 100 mg/kg protected against gastric lesions. At the same dose, BF prevented diclofenac sodium‐induced increase in tumor necrosis factor alpha (TNF‐α) and malondialdehyde (MDA) levels, and depletion of catalase (CAT) activity as well as glutathione (GSH) and prostaglandin E2 (PGE2) contents. LC‐ESI‐MS analysis revealed the presence of 12 phenolic compounds. BF exerted antiulcer action which could be linked to the presence of phenolic compounds. Practical applications Zingiber officinale has been widely consumed as a spice and used in folk medicine for treatment of gastric disorders. This is the first report evaluating the pharmacological effects of the butanol extract of ginger for the prevention of gastric ulcer. The results showed that the extract affords better gastroprotective activity against diclofenac sodium‐induced gastric ulcer in rats by reducing oxidative stress. Information provided in this study will be beneficial for developing applications of ginger in food biotechnology as functional and nutraceutical ingredient.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

et al. 2017

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“…Berberine was also proposed as a treatment for H. pylori given its anti-inflammatory effects in H. pylori -induced chronic gastritis in mice [ 107 ] and rats [ 106 ]. Brazilian folk medicinal plants Euphorbia umbellata (leitosinha) [ 108 ] and Piper umbellatum L. (Piperaceae) [ 109 ], among many others, were studied as a potential therapy for H. pylori -caused ulcers.…”

Section: Management Of Helicobacter Pylori Infectionmentioning

confidence: 99%

Impact of Dietary Patterns on H. pylori Infection and the Modulation of Microbiota to Counteract Its Effect. A Narrative Review

et al. 2021

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Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the stomach and can induce gastric disease and intra-gastric lesions, including chronic gastritis, peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. This bacterium is responsible for long-term complications of gastric disease. The conjunction of host genetics, immune response, bacterial virulence expression, diet, micronutrient availability, and microbiome structure influence the disease outcomes related to chronic H. pylori infection. In this regard, the consumption of unhealthy and unbalanced diets can induce microbial dysbiosis, which infection with H. pylori may contribute to. However, to date, clinical trials have reported controversial results and current knowledge in this field is inconclusive. Here, we review preclinical studies concerning the changes produced in the microbiota that may be related to H. pylori infection, as well as the involvement of diet. We summarize and discuss the last approaches based on the modulation of the microbiota to improve the negative impact of H. pylori infection and their potential translation from bench to bedside.

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“…They inhibited the mucosal content of platelet-activating factor in rats with gastric damage produced by acidified ethanol [ 172 ]. Rutin and quercetin isolated from Piper umbellatum L. showed antiulcer effect by exerting antioxidant, anti-secretory, anti-inflammatory and mucosa regenerative activities [ 173 ]. Hesperidin increased GSH and mucin levels and prevented oxidative cell injury in indomethacin and hypothermic restrain stress-induced ulceration models in rats [ 171 ].…”

Section: Plant Products and Phytochemicals As Antiulcerogenic And mentioning

confidence: 99%

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

et al. 2018

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In this narrative review, we have comprehensively reviewed the plant sources used as antiulcer agents. From traditional uses as herbal remedies, we have moved on to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential. A particular emphasis was also paid to Helicobacter pylori activity, with emphasis on involved mechanisms of action. Lastly, the issue of safety profile of these plant products has also been addressed.

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Piper umbellatum L.: A medicinal plant with gastric-ulcer protective and ulcer healing effects in experimental rodent models

Cited by 43 publications

References 44 publications

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

Antioxidant and gastroprotective actions of butanol fraction ofZingiber officinaleagainst diclofenac sodium-induced gastric damage in rats

Impact of Dietary Patterns on H. pylori Infection and the Modulation of Microbiota to Counteract Its Effect. A Narrative Review

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

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