Piper umbellatum L. (Piperaceae): Phytochemical profiles of the hydroethanolic leaf extract and intestinal anti-inflammatory mechanisms on 2,4,6 trinitrobenzene sulfonic acid induced ulcerative colitis in rats

Arunachalam, Karuppusamy; Damazo, Amílcar Sabino; Macho, Antonio; Lima, Joaquim Corsino da Silva; Pavan, Eduarda; Figueiredo, Fabiana de Freitas; Oliveira, Darley Maria; Cechinel‐Filho, Valdir; Wagner, Theodoro Marcel; Martins, Domingos Tabajara de Oliveira

doi:10.1016/j.jep.2020.112707

Cited by 22 publications

(8 citation statements)

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“…The species of Piperaceae are widely used for antibacterial, antifungal, and antiprotozoal (Oyedeji et al 2005;Sauter et al 2012). Arunachalam et al (2020) reported that Piper is widely used as a folk remedy to treat gastrointestinal, gastroprotective, and inflammatory disorders. Alves et al (2019) said that Piper is popularly used to treat various health conditions such as abdominal pain, skin sores, measles, and kidney problems.…”

Section: Discussionmentioning

confidence: 99%

Ethnobotany of traditional medicine in Dayak Jangkang Tribe, Sanggau District, West Kalimantan, Indonesia

et al. 2021

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Abstract. Supiandi MI, Ege B, Julung H, Zubaidah S, Mahanal S. 2021. Ethnobotany of traditional medicine in Dayak Jangkang Tribe, Sanggau District, West Kalimantan, Indonesia. Biodiversitas 22: 5417-5424. The Dayak Jangkang tribe has local knowledge about the use of medicinal plants that have been going on for a long time. Unfortunately, the local knowledge of the Dayak Jangkang tribe is currently threatened to disappear because it is delivered orally; there are no written documents and a wasteful lifestyle. The study aimed to document traditional medicinal plants that are utilized by the Dayak Jangkang tribe. The research approach used was qualitative descriptive using the field survey. The study interviewed three informants categories, i.e., the main informant (one customary chairman), key informant (one village head), and recommended informant (eight people who were knowledgeable about medicinal plants). The data were obtained through in-depth interviews and participatory observations. Data analysis used qualitative descriptive. The study got 40 plants that are used for traditional medicine with Zingiberaceae as the most used family. The parts of plants used by the Dayak Jangkang tribe for treatments were roots, bulbs, rhizomes, stems, bark, banana hump, fruit, fruit skins, leaves, fruit, and seeds. The mode of preparation is still considered simple.

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Section: Discussionmentioning

confidence: 99%

Ethnobotany of traditional medicine in Dayak Jangkang Tribe, Sanggau District, West Kalimantan, Indonesia

et al. 2021

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“…Based on a scientific literature study, the ethanol extract of the leaves of P. umbellatum has antioxidant [ 91 ], antifungal [ 92 ], anti-inflammatory [ 93 ], and anticancer [ 94 ] activity. da Silva et al [ 95 ] investigated the activity of a hydroethanolic extract from P. umbellatum leaves, which was very effective in inhibiting the activity of Enterococcus faecali s, Shigella flexneri , and Salmonella typhimurium , with an MIC value of 12.5 μg/mL…”

Section: Distribution Botanical Traditional Use and Pharmacological P...mentioning

confidence: 99%

A Review of Bioactive Compounds and Antioxidant Activity Properties of Piper Species

et al. 2022

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Antioxidants are compounds that are able to inhibit the negative effects that come from free radicals. The phenomenon of imbalanced antioxidant production and the accumulation of free radicals in cells and tissues can cause oxidative stress. Excessive free radicals that enter the body cannot be warded off by endogenous antioxidant compounds so that the required antioxidant compounds can come from the outside, which helps in the performance of endogenous antioxidants. Antioxidants that come from outside consist of synthetic and natural antioxidants; however, synthetic antioxidants are not an option because they have toxic and carcinogenic effects. Therefore, the use of natural ingredients is an alternative method that is needed to create a new natural antioxidant compound. Piper species are being considered as possible medicinal plants for the development of new sources of antioxidants. Several studies have been carried out starting from the extract levels, fractions, and compounds of the Piper species, which showed good antioxidant activity. Currently, some of these plants are being used as ingredients in traditional medicines to treat allergies, toothaches, and coughs. This review examines the distribution, botanical data, pharmacology, especially antioxidant activity, and the compounds contained in five Piper species, namely Piper amalago L., Piper betle L., Piper hispidum Sw., Piper longum L., and Piper umbellatum L.

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“…(Mimosaceae) Fruits (3) 43974 SRFCam (i) Phenolics detected among group of compounds include 2-methoxy phenol, 2-methoxyl-4vinylphenol, and 2,4-bis (1,1-dimethylethyl) phenol [33] (ii) Antioxidant and anti-inflammatory activities of hydroalcoholic extracts of Dichrostachys glomerata in gastric epithelial cells [24] Afrostyrax lepidophyllus Mildbr. (Huaceae) Seeds (3) 61286 HNC (i) Thioglycosides in seeds, 2,4,5,7-tetrathiaoctane, and other S-containing compounds in the essential oil from seeds [34,35] Piper umbellatum L. (Piperaceae) Fruits (2) 56269 SRFCam (i) Agbor et al [36] reported the antioxidant capacity of Piper umbellatum (ii) Leaf hydroethanolic extract of P. umbellatum has gastroprotective and ulcer healing against acidified ethanol (acute) and acetic acid (chronic) gastric ulcer models in rodents [37] (iii) Phytochemical profiles of the hydroethanolic leaf extract and intestinal antiinflammatory mechanisms on 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in rats [38] Monodora myristica (Gaertn.) Dunal (Annonaceae)…”

Section: Taub (Mimosaceae)mentioning

confidence: 99%

Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North‐West, Adamawa, and West Regions of Cameroon

Mikwangock

Tamfu

Amang

et al. 2023

BioMed Research International

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Aim. This study is aimed at establishing phenolic compound profile and assessing the possible antiulcer activities of aqueous extracts of some staple plant foods from the West and North-West regions of Cameroon against chronic gastric ulcer models in rats. Materials and Methods. Phenolic constituents of extracts were evaluated using HPLC-DAD. Aqueous extracts of Corchorus olitorius, Solanum nigrum, Vigna unguiculata, Triumfetta pentandra, “nkui” spices, and “yellow soup” spices were tested at two doses (200 and 400 mg/kg). After treatments, animals were sacrificed, healing percentage and antioxidant status (catalase, superoxide dismutase, and glutathione peroxidase) were evaluated, and histological examination of gastric mucosa was realized. Results. HPLC-DAD revealed that p-hydroxybenzoic and protocatechuic acids were the phenolic compound present in all extracts. Oral administration of extracts (200 and 400 mg/kg) significantly reduced ulcer surface value and significantly increased mucus production compared to the control groups ( p < 0.05 ). Histological study supported the observed healing activity of different extracts characterized by a reduced inflammatory response. Moreover, administration of aqueous extracts increased the activity of antioxidant enzymes. Conclusion. This study revealed that aqueous extracts of Solanum nigrum, Corchorus olitorius, Vigna unguiculata, Triumfetta pentandra, “yellow soup” spices, and “nkui” spices possess healing antiulcer effects against models of gastric ulcers. The antiulcer mechanisms involved may include increase of gastric mucus production and improvement of the antioxidant activity of gastric tissue. These activities may be due to the phenolic compounds identified in the extracts, especially p-hydroxybenzoic and protocatechuic acids present in all extracts and with known antioxidant, cytoprotective, and healing properties. However, all the diets may promote the healing process of chronic ulcers caused by excessive alcohol consumption/stress.

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Piper umbellatum L. (Piperaceae): Phytochemical profiles of the hydroethanolic leaf extract and intestinal anti-inflammatory mechanisms on 2,4,6 trinitrobenzene sulfonic acid induced ulcerative colitis in rats

Cited by 22 publications

References 56 publications

Ethnobotany of traditional medicine in Dayak Jangkang Tribe, Sanggau District, West Kalimantan, Indonesia

Ethnobotany of traditional medicine in Dayak Jangkang Tribe, Sanggau District, West Kalimantan, Indonesia

A Review of Bioactive Compounds and Antioxidant Activity Properties of Piper Species

Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North‐West, Adamawa, and West Regions of Cameroon

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