Pitfalls in the cytodiagnosis of metastatic squamous cell carcinoma in the head and neck: A retrospective study

Konar, Karabi; Ghosh, Sudakshina; Ghosh, T. K.; Bhattacharya, Subir; Sanyal, S.

doi:10.4103/0970-9371.50795

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…Squamous cell carcinoma shows the cervical group of lymph nodes as the most frequent site of metastasis, similar to the results in a study on malignant lesions in lymph nodes [13]. The diagnostic challenges in squamous cell carcinoma occur due to large areas of necrosis and cystic change, inflammatory reactions, and abscess formation [14]. Metastasis from adenocarcinoma was noted more in supraclavicular lymph nodes.…”

Section: Introductionsupporting

confidence: 82%

The utility of Fine Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy

Prakash

Narayanano

Mohamed³

et al. 2020

Trop J Pathol Microbiol

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Introduction: The causes of lymphadenopathy may be varied ranging from reactive to neoplastic.Fine Needle Aspiration Cytology(FNAC) is a simple and inexpensive diagnostic tool to sample cellsfrom superficial and accessible sites. Aims: This study was undertaken to assess the utility of FNACin evaluating lymphadenopathy and to study the cytomorphological spectrum of lymph node lesionsin our region. Settings and Design: A cross-sectional study of two years duration, on patients withlymphadenopathy who came to the Pathology Department for FNAC. Methods and materials:Cytology findings of Lymph node lesions were classified into four categories and were compared withhistopathology diagnosis as the gold standard. Statistical Analysis: Data was tabulated accordingto various parameters. Sensitivity, Specificity, PPV, NPV, and Diagnostic accuracy for detectingmalignancy were calculated. Results: The age range of patients included in the present studyranged from 9 to – 78 years. The mean age is 48.92 years and the median is 52 years. Thecytological diagnosis was classified as reactive in 20 cases (32.7%), inflammatory in 16 cases(26.2%), lymphoma in 3 cases (4.9%), and 22 cases (36.1%) were metastasis from other sites.Following histopathology, the cases were diagnosed to be 19 reactive lymphadenopathies, 14inflammatory lesions, 5 lymphomas, and 23 metastasis. The most common site of lymphadenopathywas the cervical region. Conclusions: FNAC has high sensitivity and specificity in differentiatingbenign lesions from malignant ones. The age, clinical findings, and supporting investigations shouldbe taken into account while diagnosing a lesion as benign or malignant.

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Section: Introductionsupporting

confidence: 82%

The utility of Fine Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy

Prakash

Narayanano

Mohamed³

et al. 2020

Trop J Pathol Microbiol

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“…The most common primary site of metastasis was oral cavity followed by the larynx, which was similar to the results obtained by Izhar. N. Bagwan et al [9] (oral cavity), Karabi Kohar et al [10](oral cavity), Malika Afroz et al [11] (larynx followed by oral cavity) Oral cavity including the buccal mucosa, palate and tongue and other adjoining areas like larynx and nasopharynx were the most common primary site of malignancy with cervical lymph node metastasis constituting up to 90%. This data points towards the fact that head and neck region malignancies are the most common to get metastasized in the cervical lymph nodes and often they are diagnosed by the FNAC of the enlarged cervical lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Cervical lymph node FNAC: a simple and sensitive tool to diagnosis malignancies

Shah¹,

Goel²,

Patel³

et al. 2019

Trop J Pathol Microbiol

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Introduction: Fine needle aspiration cytology (FNAC) of a lymph node is a simple screening and diagnostic tool to diagnose malignancies both primary as well as secondary which not only confirms the presence of metastatic disease, but also suggests regarding the nature and origin of the primary tumour. It is a well-tolerated, cost effective, almost free of complication procedure and reproducible which helps to diagnose and monitor the recurrence of malignancies. Aim: To assess the various malignant causes of cervical lymphadenopathy through FNAC. Design: A retrospective record based cross-sectional study of 125 patients with enlarged cervical lymph nodes diagnosed to have primary or secondary lymph node malignancy by cytology and confirmed by histopathology and immunohistochemistry wherever required. Materials and Methods: The material was obtained from patients, having enlarged cervical neck node over a period of one year in cytology laboratory of the Department of Pathology, Gujarat cancer research institute. Cervical lymph nodes were aspirated, and smears were prepared & processed following standard techniques. Data was collected, tabulated and then analysed. Results: In this study,125 cases of cervical lymphadenopathy were analysed. Male were affected much more commonly than females in the ratio of approximately 9:1. The most common age of presentation was fifth and the sixth decade. Most common malignancy to be diagnosed was squamous cell carcinoma. Most common primary site was oral cavity. Conclusion: FNAC is a quick, convenient and safe method for diagnosis of suspected / unsuspected metastatic and recurrence of malignancy in neck nodes.

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“…Konar et al [18] analyzed 2,512 lateral neck masses with FNA cytology in patients between 18 and 80 years old. Overall, 415 out of the 495 malignant cases had metastatic squamous cell carcinoma with secondary change.…”

Section: Discussionmentioning

confidence: 99%

Fine-Needle Aspiration Cytological Diagnosis of Neck Masses

Ashraf

Raad²,

Azarpira³

et al. 2015

Acta Cytologica

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Background: Fine-needle aspiration (FNA) is a simple, safe, inexpensive, and acceptable method for diagnosing masses, especially at superficial areas. Therefore, we decided to evaluate the accuracy of FNA cytological diagnosis in nonthyroidal, nonsalivary gland neck masses and compare the results with histopathological diagnosis. Materials and Methods: In this retrospective study, all cases with FNA cytological diagnosis of nonthyroidal, nonsalivary gland neck masses from April 2009 to July 2013 were retrieved. The procedure was done by pathologists, and all cytological and histopathological slides of the existing 46 cases were reviewed by 3 pathologists. The values of sensitivity (SN), specificity (SP), positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were calculated. Results: SN, SP, PPV, NPV, and accuracy in this study were 79, 100, 100, 73, and 86%, respectively. We had 6 false-negative and no false-positive cases. Conclusion: The FNA procedure is a reliable method as the first step for the diagnosis of nonthyroidal, nonsalivary gland neck masses. To increase the diagnostic value of cytology, careful examination of all cytological slides, repetition of the FNA procedure and good history taking are helpful.

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Pitfalls in the cytodiagnosis of metastatic squamous cell carcinoma in the head and neck: A retrospective study

Cited by 4 publications

References 4 publications

The utility of Fine Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy

The utility of Fine Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy

Cervical lymph node FNAC: a simple and sensitive tool to diagnosis malignancies

Fine-Needle Aspiration Cytological Diagnosis of Neck Masses

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