Pity or peanuts? Oxytocin induces different neural responses to the same infant crying labeled as sick or bored

Riem, Madelon M E; Voorthuis, Alexandra; Bakermans‐Kranenburg, Marian J.; IJzendoorn, Marinus H. van

doi:10.1111/desc.12103

Cited by 20 publications

(16 citation statements)

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“…In some trials, cry sounds were labelled as originating from a sick child and, in some other trials, sounds were labelled as coming from a bored child. This different interpretation of the very same infant signal produced remarkably diverging neural responses but only in the oxytocin condition . Oxytocin administration increased neural activation in the insula and inferior frontal gyrus in response to cry sounds that were labelled as coming from a sick infant.…”

Section: Oxytocin In Therapymentioning

confidence: 90%

The Role of Oxytocin in Parenting and as Augmentative Pharmacotherapy: Critical Issues and Bold Conjectures

IJzendoorn

Bakermans‐Kranenburg

2016

J Neuroendocrinology

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Despite the sometimes heated debate about the validity of human oxytocin studies, experimental oxytocin research with intranasal administration is a growing field with promising preliminary findings. The effects of intranasally administered oxytocin compared to placebo on brain neural activity have been supported in animal studies and in human studies of neural resting state. In several studies, oxytocin sniffs have been shown to lead to down-regulation of amygdala activation in response to infant attachment vocalisations. Meta-analytic evidence shows that oxytocin enhances the salience of (emotional) stimuli, lowers stress and arousal, and elevates empathic concern and tender care, in particular for offspring and in-group members. Less firm evidence points at the amnestic effects of oxytocin. We also note that the average effect sizes of oxytocin experiments are small to modest, and that most studies include a small number of subjects and thus are seriously underpowered, which implies a high risk for publication bias and nonreplicability. Nevertheless, we argue that the power of within-subjects experiments with oxytocin has been underestimated. Much more work is needed, however, to create a firm knowledge base of the neural and behavioural effects of oxytocin. Human oxytocin research is still taking place in the context of discovery, in which bold conjectures are being generated. In the context of justification, these conjectures should subsequently be subjected to stringent attempts at refutations before we jump to theoretical or clinical conclusions. For this context of justification, we propose a multisite multiple replications project on the social stimuli salience enhancing effect of oxytocin. Clinical application of oxytocin is premature. Meta-analytically, the use of oxytocin in clinical groups tends to show only effectiveness in changing symptomatology in individuals with autism spectrum disorders but, even then, it is not yet a validated therapy and its use is premature because safety and long-term side-effects have not been sufficiently studied, in particular in children.

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Section: Oxytocin In Therapymentioning

confidence: 90%

The Role of Oxytocin in Parenting and as Augmentative Pharmacotherapy: Critical Issues and Bold Conjectures

IJzendoorn

Bakermans‐Kranenburg

2016

J Neuroendocrinology

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“…Intranasal administration of OT during a double-blind placebo-controlled study ( n = 29) was associated with empathy for others in pain but not for the self (Abu-Akel, Palgi, Klein, Decety, & Shamay-Tsoory, 2015). Moreover, intranasal OT administration significantly increased neuronal activation in the insula and inferior frontal gyrus among 54 female undergraduates when responding to a baby’s cry labeled as coming from a sick infant and decreased activity in the same regions when the baby was labeled as bored (Riem, Voorthuis, Bakermans-Kranenburg, & van Ijzendoorn, 2014). …”

Section: Impaired Oxytocinergic Functioningmentioning

confidence: 99%

Family Accommodation of Child and Adolescent Anxiety: Mechanisms, Assessment, and Treatment

Norman

Silverman

Lebowitz

2015

Child Adoles Psych Nursing

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TOPIC-Anxiety disorders are the most common mental health concern for youth. Unfortunately, a substantial number of children and adolescents do not respond positively to current evidencebased interventions and/or relapse. As pediatric anxiety disorders are fundamentally a systemic phenomenon, focusing on the ways in which parents become involved in their children's anxiety symptoms may be a promising alternative approach to treatment.PURPOSE-To inform psychiatric mental health nurse practitioners (PMHNPs) about the phenomenology, associated neurobiology, and assessment of family accommodation (FA) as well as clinical interventions targeting FA. FA refers to ways that parents adapt their own behaviors to reduce their children's anxiety-related distress.SOURCES USED-A literature search was performed using Psyc-INFO and PubMed.CONCLUSIONS-Current findings indicate a high prevalence of FA associated with pediatric anxiety disorders. FA has a potentially deleterious impact on course of illness and treatment response and is associated with greater caregiver burden. Potential neurobiological underpinnings of FA include dysregulation of parent cortico-limbic circuitry and the oxytocinergic system. PMHNPs are in a unique position to identify families engaged in problematic FA, educate their clientele, provide psychotherapy services with the goal of reducing FA, and consult with multidisciplinary team members. Search termsAssessment; family accommodation; neurobiology; nursing; oxytocin; pediatric anxiety disorder; treatment Anxiety disorders are the most common mental health concern for children and adolescents, with lifetime prevalence estimates ranging upwards of 30% (Costello, Egger, & Angold, 2005;Merikangas et al., 2010 ). Pediatric anxiety disorders are chronic illnesses and are often associated with physical health concerns (Gandhi, Cheek, & Campo, 2012). They significantly impair the functioning of youth and burden families (Keller et al., 1992).Correspondence to: Eli R. Lebowitz, eli.lebowitz@yale.edu. Conflict of interest statement: KRN and WKS declare that they have no conflicts of interest. HHS Public AccessAuthor manuscript J Child Adolesc Psychiatr Nurs. Author manuscript; available in PMC 2016 August 04. Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptPsychiatric mental health nurse practitioners (PMHNPs) are in a valuable position to be agents of positive change, working at the crossroads of medicine, mental health, youth, and their families. In the current paper, we aim to discuss the need for additional treatments for youth with anxiety disorders, introduce family accommodation (FA) and its role in pediatric anxiety, and present potential neurobiological systems involved in FA. We will conclude with the assessment of FA and its modification through parent-based interventions. Our goal is not to be comprehensive, but to provide an overview of the topic and discuss the implications for PMHNPs. Clinical Interventions for Pediatric Anxiety DisordersFrontline interventions for ...

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“…As discussed before, we found a similar effect of increased salience of infant crying labeled as coming from a sick child compared to crying coming from a bored child. Alarming social cues -but not neutral cues -seem to trigger more neural activity in the oxytocin condition than in the placebo condition (Riem et al 2014).…”

Section: Protective Parentingmentioning

confidence: 85%

“…We measured neural responses to the same crying sounds in two contexts: once it was indicated as coming from a sick infant, and once as coming from a bored infant. Oxytocin significantly increased insula and inferior frontal gyrus responding to sick infant crying, but decreased activation in these brain regions during exposure to crying of an infant that was labeled as bored (Riem et al 2014). Labeling the same infant crying as "sick" or as "bored" thus drastically changed neural activity in response to intranasal oxytocin administration.…”

Section: Oxytocin and Parenting: Potential Mechanismsmentioning

confidence: 93%

Oxytocin and Human Sensitive and Protective Parenting

Bakermans‐Kranenburg

IJzendoorn

2017

Behavioral Pharmacology of Neuropeptides: Oxytocin

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In this chapter we review the evidence for the role of oxytocin in parenting, and discuss some crucial but outstanding questions. This is not meant to be a comprehensive review of all studies on oxytocin and parenting in general. Instead, special attention will be paid to a dimension of parenting that has been largely neglected in behavioral and neurobiological research on parental caregiving, namely protection. Parental protection has received considerable attention in animal research but, despite its evolutionary importance, not in studies on humans. It is argued that oxytocin may have specific significance for the protective dimension of parenting. The effects of exogenous oxytocin may be dependent not only on contextual factors, but also on personal characteristics, most notably gender, on endogenous levels of oxytocin, and on early childhood experiences. Examining the contextual, personal, hormonal, neural, genetic, and behavioral mechanisms of protective parenting in tandem is essential for the development of a comprehensive theory of protective parenting, and for the identification of "biomarkers" for insensitive and unprotective parenting that should be taken into account in preventive parenting interventions.

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Pity or peanuts? Oxytocin induces different neural responses to the same infant crying labeled as sick or bored

Cited by 20 publications

References 36 publications

The Role of Oxytocin in Parenting and as Augmentative Pharmacotherapy: Critical Issues and Bold Conjectures

The Role of Oxytocin in Parenting and as Augmentative Pharmacotherapy: Critical Issues and Bold Conjectures

Family Accommodation of Child and Adolescent Anxiety: Mechanisms, Assessment, and Treatment

Oxytocin and Human Sensitive and Protective Parenting

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