Pityriasis rubra pilaris and HIV infection

Blauvelt, Andrew; Nahass, George T.; Pardo, Rube J.; Kerdel, Francisco A.

doi:10.1016/0190-9622(91)70106-c

Cited by 56 publications

(39 citation statements)

References 4 publications

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“…Although other entities, such as pityriasis rubra pilaris, lichen spinulosus and HIV-associated occlusion follicular syndrome, have been linked to HIV infection [2,3,4,5,6,7,8], we have not observed any such case, so we consider them rare diseases. There are many diseases that can present as itchy folliculitis in HIV-infected patients and are related to immunosuppression and/or immunorestoration [19].…”

Section: Discussionmentioning

confidence: 72%

“…Several dermatoses with follicular occlusion have been described in HIV-infected patients, including acne vulgaris, drug-induced acneiform eruptions, a special form of pityriasis rubra pilaris, lichen spinulosus and acne inversa (hidradenitis suppurativa) [1,2,3,4,5]. These entities appear isolated or associated with each other in an independent disease named ‘HIV-associated follicular syndrome’ [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Acne Is Not a Stigma of HIV Infection: A Review of 36 Patients

Almagro¹,

Pozo²,

García-Silva³

et al. 2005

Dermatology

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Introduction: Several diseases with follicular occlusion have been described in HIV-infected patients and can appear isolated or associated with each other in an independent disease named ‘HIV-associated follicular syndrome’. Worsening of cutaneous lesions during the course of infection in patients with previous acne vulgaris, late onset or severe forms of acne have been reported in HIV-infected patients. Patients and Methods: A prospective study of 335 HIV-infected patients was performed in our hospital. A meticulous dermatological exploration in all patients was made, and multiple data were stored into a Microsoft Access 97 program. Patients diagnosed as having acne were considered separately, and we studied their characteristics. A statistical analysis with SPSS 9.0 (Statistical Package for the Social Sciences) was performed. Results: Thirty-six patients (10.8%) were diagnosed as having acne. Papulopustular lesions were the most frequent clinical presentation. Most lesions were localized on the face or on the back, and 80% of patients had mild to moderate acne; 40% of them required no treatment and the remainder was treated with topical measures, oral antibiotics and isotretinoin. 85% of cases reported the onset of acne during adolescence or before HIV infection and without any relationship with this disease. No relation between acne intensity and stage of HIV infection was observed. A multivariate analysis showed that the most important variable was age. Discussion: In contrast to previous reports, no greater intensity or modifications in acne lesions were observed in our HIV-infected patients during the course of the disease. In the majority of cases, cutaneous lesions started before HIV infection, during adolescence, and the most important factor for suffering from acne was young age. In contrast to data reported in the literature, no relation of acne lesions to CD4 lymphocyte count or AIDS case criteria was found in our patients. Conclusions: Acne in HIV-infected patients has characteristics similar to those in non-HIV-infected patients. The age is the most important factor for the appearance of lesions that usually develop during adolescence. Acne lesions are not modified by HIV infection, and no relationship with the severity of HIV infection has been observed.

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Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Acne Is Not a Stigma of HIV Infection: A Review of 36 Patients

Almagro¹,

Pozo²,

García-Silva³

et al. 2005

Dermatology

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“…Both familial and acquired forms of the disease have been described [7,910]. PRP has been reported in association with HIV infection [11][12][13], malignancy [4] and Down's syndrome [14]. PRP has been reported to occur simultaneously with several autoimmune disorders [7,6,15,16] including thyroiditis [15,16], myositis [17], myasthenia gravis [18], coeliac sprue [19] and vitiligo [14].…”

Section: Discussionmentioning

confidence: 99%

“…Recent reports have suggested that immune dysregulation may also play a role in the pathogenesis of PR [7], based on T-lymphocyte abnormalities [27], lymphocyte hypersensitivity to super antigens [28] and relationship to HIV infection [11][12][13]29]. It was speculated that the disorder might be the result of an abnormal immune response to some antigenic stimuli [6,8].…”

Section: Discussionmentioning

confidence: 99%

Systemic sclerosis in a patient with pityriasis rubra pilaris

Frikha¹,

Frigui²,

Masmoudi³

et al. 2011

Pan Afr Med Jrnl

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Pityriasis rubra pilaris (PRP) is a rare, chronic erythematous squamous disorder of unknown etiology. It has been found in association with several autoimmune diseases, including thyroiditis, myositis, myasthenia gravis and vitiligo. Herein we report a case of systemic sclerosis in a patient with classic adult pityriasis rubra pilaris. A 38 year old woman with classic adult type 1 pityriasis rubra pilaris (PRP) developed progressive skin thickening of the trunk, face, upper and lower extremities after 2 years of PRP treatment with topical emollients and steroids. Clinical examination and immunological findings were consistent with SSc. Co-existence of these two rare conditions is documented for the first time.

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“…Manchmal tritt die PRP bei Patienten mit Grunderkrankungen auf, wie z. B. Myasthenia gravis [53] Sklerodermatomyositis [29], HIV-Infektion [4,8], Hepatitis-C-Infektion [11], Leukämie [37], Lungenkrebs und Karzinomen mit unbekanntem Primärtumor mit Lebermetastasen [41] sowie hepatozellulärem Karzinom [42]. Darüber hinaus sind Berichte über eine autosomal-dominante Vererbung der PRP veröffentlicht worden [51].…”

Section: äTiologie Und Epidemiologieunclassified