PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer

Su, Jing-Fen; Concilla, Anthony; Zhang, Dianzheng; Zhao, Fen; Shen, Fangfang; Zhang, Hao; Zhou, Fuyou

doi:10.1016/j.gendis.2020.09.006

Cited by 21 publications

(17 citation statements)

References 155 publications

(324 reference statements)

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“…5) What are the roles of piRNAs in cancer stemness? The emerging roles of piRNAs in mediating cancer stem cell (CSC)-like properties have been observed (Su et al, 2021).…”

Section: Therapeutic Approaches Using Piwi-interacting Rnasmentioning

confidence: 99%

PIWI-Interacting RNAs (piRNAs): Promising Applications as Emerging Biomarkers for Digestive System Cancer

Cai

Zhou

et al. 2022

Front. Mol. Biosci.

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PIWI-interacting RNAs (piRNAs) are a novel type of small non-coding RNAs (sncRNAs), which are 26–31 nucleotides in length and bind to PIWI proteins. Although piRNAs were originally discovered in germline cells and are thought to be essential regulators for germline preservation, they can also influence gene expression in somatic cells. An increasing amount of data has shown that the dysregulation of piRNAs can both promote and repress the emergence and progression of human cancers through DNA methylation, transcriptional silencing, mRNA turnover, and translational control. Digestive cancers are currently a major cause of cancer deaths worldwide. piRNAs control the expression of essential genes and pathways associated with digestive cancer progression and have been reported as possible biomarkers for the diagnosis and treatment of digestive cancer. Here, we highlight recent advances in understanding the involvement of piRNAs, as well as potential diagnostic and therapeutic applications of piRNAs in various digestive cancers.

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“…5) What are the roles of piRNAs in cancer stemness? The emerging roles of piRNAs in mediating cancer stem cell (CSC)-like properties have been observed (Su et al, 2021).…”

Section: Therapeutic Approaches Using Piwi-interacting Rnasmentioning

confidence: 99%

PIWI-Interacting RNAs (piRNAs): Promising Applications as Emerging Biomarkers for Digestive System Cancer

Cai

Zhou

et al. 2022

Front. Mol. Biosci.

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“…Moreover, the presence of piRNAs within the mitochondria has been detected 33 , although their biogenesis, variability, and potential functionality is still unclear. Furthermore, linkage between mitochondria and the piRNA biogenesis pathway has been clearly established on the basis of localization of the mitochondrial membrane-associated Zuc/MitoPLD protein, capable of hydrolyzing a mitochondria-specific lipid, cardiolipin; in turn, Zuc/MitoPLD is key to the biogenesis and functional activity of piRNAs 34 – 37 .…”

Section: Introductionmentioning

confidence: 99%

Unraveling mitochondrial piRNAs in mouse embryonic gonadal cells

Barreñada

Larriba

Fernández-Pérez

et al. 2022

Sci Rep

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Although mitochondria are widely studied organelles, the recent interest in the role of mitochondrial small noncoding RNAs (sncRNAs), miRNAs, and more recently, piRNAs, is providing new functional perspectives in germ cell development and differentiation. piRNAs (PIWI-interacting RNAs) are single-stranded sncRNAs of mostly about 20–35 nucleotides, generated from the processing of pre-piRNAs. We leverage next-generation sequencing data obtained from mouse primordial germ cells and somatic cells purified from early-differentiating embryonic ovaries and testis from 11.5 to 13.5 days postcoitum. Using bioinformatic tools, we elucidate (i) the origins of piRNAs as transcribed from mitochondrial DNA fragments inserted in the nucleus or from the mitochondrial genome; (ii) their levels of expression; and (iii) their potential roles, as well as their association with genomic regions encoding other sncRNAs (such as tRNAs and rRNAs) and the mitochondrial regulatory region (D-loop). Finally, our results suggest how nucleo-mitochondrial communication, both anterograde and retrograde signaling, may be mediated by mitochondria-associated piRNAs.

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“…У мух предшественники пиРНК происходят из гетерохроматических локусов, тогда как у млекопитающих кластеры пиРНК неотличимы от транскрипционных единиц РНК полимеразы II канонической эухроматической ДНК [200]. Функции пиРНК в последнее время активно изучаются (см., например, обзоры в [201][202][203][204]).…”

Section: рнк взаимодействующие с белками Piwiunclassified

Variety of Non-Coding RNAs in Eukaryotic Genomes

Nazipova¹

2021

Math.Biol.Bioinf.

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The genomes of large multicellular eukaryotes mainly consist of DNA that encodes not proteins, but RNAs. The unexpected discovery of approximately the same number of protein genes in Homo sapiens and Caenorhabditis elegans led to the understanding that it is not the number of proteins that determines the complexity of the development and functioning of an organism. The phenomenon of pervasive transcription of genomes is finding more and more confirmation. Data are emerging on new types of RNA that work in different cell compartments, are expressed at different stages of development, in different tissues and perform various functions. Their main purpose is fine regulation of the main cellular processes. The presence of a rich arsenal of regulators that can interact with each other and work on the principle of interchangeability determines the physiological complexity of the organism and its ability to adapt to changing environmental conditions. An overview of the currently known functional RNAs expressed in eukaryotic genomes is presented here. There is no doubt that in the near future, using high-tech transcriptome technologies, many new RNAs will be identified and characterized. But it is likely that many of the expressed transcripts do not have a function, but are an evolutionary reserve of organisms.

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PIWI-interacting RNAs: Mitochondria-based biogenesis and functions in cancer

Cited by 21 publications

References 155 publications

PIWI-Interacting RNAs (piRNAs): Promising Applications as Emerging Biomarkers for Digestive System Cancer

PIWI-Interacting RNAs (piRNAs): Promising Applications as Emerging Biomarkers for Digestive System Cancer

Unraveling mitochondrial piRNAs in mouse embryonic gonadal cells

Variety of Non-Coding RNAs in Eukaryotic Genomes

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