Placental Expression and Relative Role of Anti-inflammatory Annexin A1 and Animal Lectin Galectin-3 in the Pathogenesis of Preeclampsia

Ruikar, Komal; Aithal, Manjunath; Shetty, Praveenkumar; Dinesh, US; Bargale, Anil; Sadashiv, Roshni; Sarathkumar, E.; Khode, Vitthal; Desai, Rathnamala M; Patil, Prakash

doi:10.1007/s12291-020-00952-z

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…The relative quantification of gal-3 genes' expression was determined in CKD patients and controls using quantitative real-time reverse transcription-PCR (qRT-PCR). The primers used were chosen from genetic codes published in Gen Bank (Eurofins) 13 (Table 1). RNA extraction, purification, and reverse transcription of RNA into cDNA were carried out as previously described 14 .…”

Section: Relative Quantification Of Gal-3 Gene's Expressionmentioning

confidence: 99%

Association of Galectin-3 and IL-33/ST2 Axis with Chronic Kidney Disease Severity: Do They Play A Role in Associated Comorbidities?

Shreet,

Embarek,

KhairAllah

et al. 2024

Egyptian Journal of Medical Microbiology

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Background: Elevated Galectin-3 (Gal-3) levels and Interleukin 33 (IL-33)/suppression of tumorigenicity 2 )ST2 ( involved in the pathophysiology of incident chronic kidney disease (CKD), and renal fibrosis. Besides, IL-33 induces fibrosis of pulmonary, hepatic, skin, renal, and pancreatic tissues in a way that is dependent on ST2., whereas, plays a protective role against cardiac fibrosis and atherosclerosis. Objective: the aim of this study was to investigate the association between Gal-3 and the IL-33/ST2 axis with CKD severity and the incidence of associated multi-organ affection. Methodology: Eighty one subjects were enrolled in this study; 69 patients with CKD and 12 age-and sex-matched healthy controls. Disease severity was assessed by estimated glomerular filtration rate (eGFR), and patients were classified as having mild, moderate, or severe CKD. Serum Gal-3, IL-33, and sST2 were tested by ELISA and the expression level of Gal-3 was assessed by Real-time PCR. Results: Serum Gal-3, IL-33, ST2, and the Gal-3 gene expression levels significantly increased as the severity of CKD increases. Correlation analysis showed significant associations between serum creatinine, serum Gal-3, serum IL-33, serum ST2, and the Gal-3 gene level. Conclusion: Concentrations of sST2, and the Gal-3 gene expression were directly proportional with the level of CKD severity highlighting the important role of these mechanisms in the progression of kidney disease. Accordingly, these biomarkers may be useful tools for disease monitoring and individualized therapies to slow the advancement of CKD as well as associated diabetes and heart disease.

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Section: Relative Quantification Of Gal-3 Gene's Expressionmentioning

confidence: 99%

Association of Galectin-3 and IL-33/ST2 Axis with Chronic Kidney Disease Severity: Do They Play A Role in Associated Comorbidities?

Shreet,

Embarek,

KhairAllah

et al. 2024

Egyptian Journal of Medical Microbiology

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“…Recent investigations involving ANXA1 suggest that the modulation of this protein may be associated with the systemic inflammatory response present in pregnancyassociated pre-eclampsia [59,60]. Behrouz et al identified that pregnant women with PE had increased levels of autoantibodies against two placental proteins: ANXA1 and the "vitamin D binding protein" in serum.…”

Section: Anxa1 In the Placentamentioning

confidence: 99%

ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus

Sousa

Santos

Teixeira

et al. 2022

Cells

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The unbiased approaches of the last decade have enabled the collection of new data on the biology of annexin A1 (ANXA1) in a variety of scientific aspects, creating opportunities for new biomarkers and/or therapeutic purposes. ANXA1 is found in the plasma membrane, cytoplasm, and nucleus, being described at low levels in the nuclear and cytoplasmic compartments of placental cells related to gestational diabetic diseases, and its translocation from the cytoplasm to the nucleus has been associated with a response to DNA damage. The approaches presented here open pathways for reflection upon, and intrinsic clarification of, the modulating action of this protein in the response to genetic material damage, as well as its level of expression and cellular localization. The objective of this study is to arouse interest, with an emphasis on the mechanisms of nuclear translocation of ANXA1, which remain underexplored and may be beneficial in new inflammatory therapies.

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“…Galectin-1 overexpression in PE placentas, compared to placentas in normal pregnancy [78,94] Downregulation of galectin-1 in early-onset PE placentas [95] Galectin-1-expressing peripheral blood T and NK cells proportion is decreased in women who developed PE compared to normal pregnancy [96] Downregulation of galectin-1 in early-onset PE placentas [95,97] Low serum galectin-1 levels during the second trimester might be a PE risk [97,98] Galectin-2 is downregulated at protein and mRNA levels in EVTs in PE placentas Galectin-2 serum levels are lower in PE patients compared to patients with uncomplicated pregnancies [99] Galectin-3 mRNA and protein levels are increased in PE placental tissue in comparison to normal pregnancy placentas [100] Galectin-3 is overexpressed in EVT and STB of PE placentas in comparison to normal pregnancy placentas [94,100,101] Galectin-3 serum levels are higher in PE patients compared to patients with uncomplicated pregnancies [101,102] Galectin-7 serum levels are higher in women who developed PE in comparison to uncomplicated pregnancies [16] Altered expression of galectin-9 is detected on peripheral blood lymphocytes in early-onset pre-eclamptic women Galectin-13 mRNA and protein levels are decreased in placenta tissue in early-and late-onset PE in comparison to healthy pregnancies [84][103,104] Galectin-13 is overexpressed in STB microvillous membrane in PE compared to healthy controls Low galectin-13 serum protein level during first trimester, with rapid increase starting with second trimester in women who subsequently develop PE Galectin-13 in combination with other (bio)markers is a promising tool in PE prediction [103][62] [105] Table 1. Cont.…”

Section: Process/pathology Involvement Of Galectins Reference Inflammation/infectionmentioning

confidence: 99%

“…Several studies showed galectin-3 overexpression in PE patients. Increased galectin-3 mRNA and protein levels were detected in PE placental tissue in comparison to normal pregnancy placentas [ 100 ]. Although different cell types of term placenta express galectin-3, increased expression of this lectin in EVT and STB was connected to PE [ 94 , 100 , 101 ].…”

Section: Galectins In Pregnancy-related Disordersmentioning

confidence: 99%

“…Increased galectin-3 mRNA and protein levels were detected in PE placental tissue in comparison to normal pregnancy placentas [ 100 ]. Although different cell types of term placenta express galectin-3, increased expression of this lectin in EVT and STB was connected to PE [ 94 , 100 , 101 ]. Furthermore, serum galectin-3 levels were significantly higher in PE patients compared to those with uncomplicated pregnancy [ 101 , 102 ].…”

Section: Galectins In Pregnancy-related Disordersmentioning

confidence: 99%

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Galectins in Early Pregnancy and Pregnancy-Associated Pathologies

Krivokuća

Vilotić

Nacka-Aleksić

et al. 2021

IJMS

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Galectins are a family of conserved soluble proteins defined by an affinity for β-galactoside structures present on various glycoconjugates. Over the past few decades, galectins have been recognized as important factors for successful implantation and maintenance of pregnancy. An increasing number of studies have demonstrated their involvement in trophoblast cell function and placental development. In addition, several lines of evidence suggest their important roles in feto-maternal immune tolerance regulation and angiogenesis. Changed or dysregulated galectin expression is also described in pregnancy-related disorders. Although the data regarding galectins’ clinical relevance are still at an early stage, evidence suggests that some galectin family members are promising candidates for better understanding pregnancy-related pathologies, as well as predicting biomarkers. In this review, we aim to summarize current knowledge of galectins in early pregnancy as well as in pregnancy-related pathologies.

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Placental Expression and Relative Role of Anti-inflammatory Annexin A1 and Animal Lectin Galectin-3 in the Pathogenesis of Preeclampsia

Cited by 8 publications

References 29 publications

Association of Galectin-3 and IL-33/ST2 Axis with Chronic Kidney Disease Severity: Do They Play A Role in Associated Comorbidities?

Association of Galectin-3 and IL-33/ST2 Axis with Chronic Kidney Disease Severity: Do They Play A Role in Associated Comorbidities?

ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus

Galectins in Early Pregnancy and Pregnancy-Associated Pathologies

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