Placental Vascular Obstructive Lesions: Risk Factor for Developing Necrotizing Enterocolitis

Dix, Laure; Roth‐Kleiner, Matthias; Osterheld, Maria‐Chiara

doi:10.4061/2010/838917

Cited by 10 publications

(9 citation statements)

References 42 publications

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“…In addition, some studies have identified a relationship between NEC and fetal thrombotic vasculopathy or fetal vascular obstructive lesions [4; 48]. In our study, fetal large vessel thrombi were significantly associated with an increased risk of NEC and trended with an increased risk of ROP and BPD.…”

Section: Discussionsupporting

confidence: 65%

Correlation of preterm infant illness severity with placental histology

et al. 2016

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Section: Discussionsupporting

confidence: 65%

Correlation of preterm infant illness severity with placental histology

et al. 2016

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“…The etiology of NEC is still poorly understood, but it is believed to be multifactorial [87]. Several studies found an association between NEC and placental lesions, in particular fetal vascular obstructive lesions (fetal thrombotic vasculopathy, congested villi, coagulation-related lesions) with ORs ranging from 2.6 to 9.10 (95% CI: 1.13–15.08) [26], [32], [33]. The presence of ischemia has been proposed as an explanation for the etiology of NEC.…”

Section: Resultsmentioning

confidence: 99%

Placental Pathology, Perinatal Death, Neonatal Outcome, and Neurological Development: A Systematic Review

et al. 2014

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BackgroundThe placenta plays a crucial role during pregnancy for growth and development of the fetus. Less than optimal placental performance may result in morbidity or even mortality of both mother and fetus. Awareness among pediatricians, however, of the benefit of placental findings for neonatal care, is limited.ObjectivesTo provide a systematic overview of the relation between placental lesions and neonatal outcome.Data sourcesPubmed database, reference lists of selected publications and important research groups in the field.Study appraisal and synthesis methodsWe systematically searched the Pubmed database for literature on the relation between placental lesions and fetal and neonatal mortality, neonatal morbidity and neurological outcome. We conducted three separate searches starting with a search for placental pathology and fetal and neonatal mortality, followed by placental pathology and neonatal morbidity, and finally placental pathology and neurological development. We limited our search to full-text articles published in English from January 1995 to October 2013. We refined our search results by selecting the appropriate articles from the ones found during the initial searches. The first selection was based on the title, the second on the abstract, and the third on the full article. The quality of the selected articles was determined by using the Newcastle-Ottawa Quality Assessment Scale.ResultsPlacental lesions are one of the main causes of fetal death, where placental lesions consistent with maternal vascular underperfusion are most important. Several neonatal problems are also associated with placental lesions, whereby ascending intrauterine infection (with a fetal component) and fetal thrombotic vasculopathy constitute the greatest problem.ConclusionsThe placenta plays a key role in fetal and neonatal mortality, morbidity, and outcome. Pediatricians should make an effort to obtain the results of placental examinations.

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“…As described above, high grade FVM (fetal thrombotic vasculopathy) has the highest rate of associated adverse outcomes, particularly CNS abnormalities (cerebral palsy, neonatal encephalopathy, perinatal stroke, intracranial hemorrhage) . Less well established associations with placental FVM include maternal diabetes and a variety of fetal/neonatal abnormalities including necrotizing enterocolitis, congenital leukemia, neonatal alloimmune thrombocytopenia, gastroschisis, and non‐cardiac congenital malformations .…”

Section: Clinical Correlationsmentioning

confidence: 99%

Fetal vascular malperfusion, an update

Redline

Ravishankar

2018

APMIS

154

104

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Fetal vascular malperfusion is the most recent term applied to a group of placental lesions indicating reduced or absent perfusion of the villous parenchyma by the fetus. The most common etiology of malperfusion is umbilical cord obstruction leading to stasis, ischemia, and in some cases thrombosis. Other contributing factors may include maternal diabetes, fetal cardiac insufficiency or hyperviscosity, and inherited or acquired thrombophilias. Severe or high grade fetal vascular malperfusion is an important risk factor for adverse pregnancy outcomes including fetal growth restriction, fetal CNS injury, and stillbirth. Overall recurrence risk for subsequent pregnancies is low.

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Placental Vascular Obstructive Lesions: Risk Factor for Developing Necrotizing Enterocolitis

Cited by 10 publications

References 42 publications

Correlation of preterm infant illness severity with placental histology

Correlation of preterm infant illness severity with placental histology

Placental Pathology, Perinatal Death, Neonatal Outcome, and Neurological Development: A Systematic Review

Fetal vascular malperfusion, an update

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