Planar images reprojected from SPECT V/Q data perform similarly to traditional planar V/Q scans in the diagnosis of pulmonary embolism

Kyrtatos, Panagiotis G.; Burniston, Maria; Wagner, Thomas

doi:10.1097/mnm.0b013e32835fa531

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Little evidence of RBS exists in the literature. The usage of reprojected SPECT has been previously validated for lung imaging [8,9], but for now, to our knowledge, its application for bone imaging has only appeared in a conference article [10] and as an image of the month in the European Journal of Nuclear Medicine and Molecular Imaging [7]. In this paper, we test the RBS method for the detection of bone metastases in primary staging of high-risk breast and prostate cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Comparison of reprojected bone SPECT/CT and planar bone scintigraphy for the detection of bone metastases in breast and prostate cancer

Arvola

Seppänen

Malaspina

et al. 2022

Nuclear Medicine Communications

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Objective The aim of this study was to compare reprojected bone SPECT/CT (RBS) against planar bone scintigraphy (BS) in the detection of bone metastases in breast and prostate cancer patients. Methods Twenty-six breast and 105 prostate cancer patients with high risk for bone metastases underwent 99mTc-HMDP BS and whole-body SPECT/CT, 1.5-T whole-body diffusion-weighted MRI and 18F-NaF or 18F-PSMA-1007 PET/CT within two prospective clinical trials (NCT01339780 and NCT03537391). Consensus reading of all imaging modalities and follow-up data were used to define the reference standard diagnosis. The SPECT/CT data were reprojected into anterior and posterior views to produce RBS images. Both BS and RBS images were independently double read by two pairs of experienced nuclear medicine physicians. The findings were validated against the reference standard diagnosis and compared between BS and RBS on the patient, region and lesion levels. Results All metastatic patients detected by BS were also detected by RBS. In addition, three metastatic patients were missed by BS but detected by RBS. The average patient-level sensitivity of two readers for metastases was 75% for BS and 87% for RBS, and the corresponding specificity was 79% for BS and 39% for RBS. The average region-level sensitivity of two readers was 64% for BS and 69% for RBS, and the corresponding specificity was 96% for BS and 87% for RBS. Conclusion Whole-body bone SPECT/CT can be reprojected into more familiar anterior and posterior planar images with excellent sensitivity for bone metastases, making additional acquisition of planar BS unnecessary.

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Section: Introductionmentioning

confidence: 99%

Comparison of reprojected bone SPECT/CT and planar bone scintigraphy for the detection of bone metastases in breast and prostate cancer

Arvola

Seppänen

Malaspina

et al. 2022

Nuclear Medicine Communications

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“…In recent studies, fast SPECT protocols have shown promise on reducing imaging time without loss of diagnostic quality [ 14 , 15 ]. In addition, it is possible to substitute “true” PBS with re-projected “synthetic” PBS derived from the WB-SPECT/CT, as has been done previously with lung imaging [ 16 , 17 ]. Such a workflow allows planar images to be available to aid in clinician reading, which is preferable during a transition phase to tomographic only data due to historical familiarity, without the requirement for additional scanning.…”

Section: Introductionmentioning

confidence: 99%

Transition to Fast Whole-Body SPECT/CT Bone Imaging: An Assessment of Image Quality

et al. 2022

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Objective: To investigate the impact of reduced SPECT acquisition time on reconstructed image quality for diagnostic purposes. Method: Data from five patients referred for a routine bone SPECT/CT using the standard multi-bed SPECT/CT protocol were reviewed. The acquisition time was 900 s using gating technique; SPECT date was resampled into reduced data sets of 480 s, 450 s, 360 s and 180 s acquisition duration per bed position. Each acquisition time was reconstructed using a fixed number of subsets (8 subsets) and 4, 8, 12, and 16 iterations, followed by a post-reconstruction 3D Gaussian filter of 8 mm FWHM. Two Nuclear Medicine physicians analysed all images independently to score image quality, noise and diagnostic confidence based on a pre-defined 4-point scale. Results: Our result showed that the most frequently selected categories for 480 s and 450 s images were good image quality, average noise and fair confidence, particularly at lower iteration numbers 4 and 8. For the shortened acquisition time of 360 s and 180 s, statistical significance was observed in most reconstructed images compared with 900 s. Conclusion: The SPECT/CT can significantly shorten the acquisition time with maintained image quality, noise and diagnostic confidence. Therefore, acquiring data over 480 s and 450 s is feasible for WB-SPECT/CT bone scans to provide an optimal balance between acquisition time and image quality.

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Verification of reprojected planar images generated from a ring-configured cadmium zinc telluride gamma camera in scintigraphy for diagnosing transthyretin cardiac amyloidosis

Cerić Andelius,

Fridriksdóttir,

Minarik

et al. 2024

European Heart Journal - Imaging Methods and Practice

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Background Non-invasive diagnosis of amyloid transthyretin (ATTR) cardiac amyloidosis using planar scintigraphy and single-photon emission computed tomography – computed tomography (SPECT-CT) with 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD) has high specificity and sensitivity. However, the introduction of ring-configured cadmium zinc telluride (CZT) gamma cameras warrants an update in the acquisition method since these systems are not able to perform planar scintigraphy. We aimed to verify the use of reprojected anterior planar images generated from reconstructed SPECT-CT to replace planar scintigraphy. Methods and Results The study examined 30 patients referred for clinically indicated 99mTc-DPD scintigraphy who were scanned with both a conventional camera and a ring-configured CZT camera. Planar images from the conventional system were compared to reprojected planar images from the ring-configured CZT system. The images were evaluated in regard to image quality and Perugini score in a blinded fashion by three nuclear medicine physicians. Heart-to-contralateral (H/CL) ratios were calculated. There were 27 patients who had an identical Perugini scores in planar and reprojected planar images, yielding a strong level of agreement and inter-rater reliability among the three readers (κ=0.85, R< 0.001). For the three patients scored differently (scored as Perugini 0 or Perugini 1), SPECT-CT was requested for full assessment. The H/CL ratios showed a strong correlation ratio (r=0.98, p < 0.0001). A shift towards lower image quality was seen for the reprojected images. Conclusions Reprojected planar images generated from 99mTc-DPD SPECT-CT scintigraphy can be used to score ATTR amyloidosis and extract H/CL ratios in the same way as planar images.

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Planar images reprojected from SPECT V/Q data perform similarly to traditional planar V/Q scans in the diagnosis of pulmonary embolism

Abstract: We have shown that the performance of reprojected planars from SPECT V/Q was similar to that of traditional planars. These results have potential important implications for patient workflow in busy nuclear medicine departments, as well as for patient comfort.

Cited by 3 publications

References 9 publications

Comparison of reprojected bone SPECT/CT and planar bone scintigraphy for the detection of bone metastases in breast and prostate cancer

Comparison of reprojected bone SPECT/CT and planar bone scintigraphy for the detection of bone metastases in breast and prostate cancer

Transition to Fast Whole-Body SPECT/CT Bone Imaging: An Assessment of Image Quality

Verification of reprojected planar images generated from a ring-configured cadmium zinc telluride gamma camera in scintigraphy for diagnosing transthyretin cardiac amyloidosis

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