Plant Food, Nutrition, and Human Health

Mena, Pedro; Angelino, Donato

doi:10.3390/nu12072157

Cited by 19 publications

(10 citation statements)

References 23 publications

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“…(MO), commonly referred to as "drumstick tree," "horseradish tree," or "miracle tree", belongs to the flowering plant family Moringaceae and is widely cultivated in Africa, Asia, and the Americas [3]. A large variety of nutritional and medicinal virtues have been shown in its leaves, seeds, flowers, and bark [4,5]. Its leaves are, for example, commonly consumed as vegetables and nutritional supplements; the seeds are taken fresh, dried or as roasted tea.…”

Section: Introductionmentioning

confidence: 99%

Moringa oleifera Lam. in Diabetes Mellitus: A Systematic Review and Meta-Analysis

et al. 2021

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Plant-derived phytochemicals have been interested in as nutraceuticals for preventing the onset and progress of diabetes mellitus and its serious complications in recent years. Moringa oleifera Lam. is used in vegetables and in herbal medicine for its health-promoting properties against various diseases including diabetes mellitus. This study aimed to examine an effect of Moringa oleifera on diabetic hyperglycemia and dyslipidemia by meta-analyzing the current evidence of diabetic rodent models. Peer-reviewed studies written in English from two databases, PubMed and Embase, were searched to 30 April 2021. Studies reporting blood glucose or lipid levels in diabetic rodents with and without receiving extracts of Moringa oleifera were included. Forty-four studies enrolling 349 diabetic rodents treated with extracts of Moringa oleifera and 350 diabetic controls reported blood glucose levels. The pooled effect size was −3.92 (95% CI: −4.65 to −3.19) with a substantial heterogeneity. This effect was likely to be, at least in part, modified by the type of diabetic models. Moreover, diabetic hypertriglyceridemia and hypercholesterolemia were also significantly improved in diabetic rodent models treated with Moringa oleifera.

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Section: Introductionmentioning

confidence: 99%

Moringa oleifera Lam. in Diabetes Mellitus: A Systematic Review and Meta-Analysis

et al. 2021

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“…It is well known that plants produce a plethora of secondary metabolites that can influence human health when consumed (Russell & Duthie, 2011 ; Teoh, 2015 ). Multiple studies have focused on the bioactivity and nutritional relevance of several classes of phytochemicals such as carotenoids, flavonoids, saponins and glucosinolates (Marzocchella et al., 2011 ; Mena & Angelino, 2020 ) . As such, it is possible that these secondary metabolites can be encapsulated within PDVs and contribute to PDVs’ intrinsic therapeutic activities.…”

Section: Composition and Classification Of Pdvsmentioning

confidence: 99%

Plant‐derived extracellular vesicles: Recent advancements and current challenges on their use for biomedical applications

Lian

Chng

Liang

et al. 2022

J of Extracellular Vesicle

101

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Extracellular vesicles (EVs) represent a diverse class of lipid bilayer membrane vesicles released by both animal and plant cells. These ubiquitous vesicles are involved in intercellular communication and transport of various biological cargos, including proteins, lipids, and nucleic acids. In recent years, interest in plant‐derived EVs has increased tremendously, as they serve as a scalable and sustainable alternative to EVs derived from mammalian sources. In vitro and in vivo findings have demonstrated that these plant‐derived vesicles (PDVs) possess intrinsic therapeutic activities that can potentially treat diseases and improve human health. In addition, PDVs can also act as efficient and biocompatible drug carriers. While preclinical studies have shown promising results, there are still several challenges and knowledge gaps that have to be addressed for the successful translation of PDVs into clinical applications, especially in view of the lack of standardised protocols for material handling and PDV isolation from various plant sources. This review provides the readers with a quick overview of the current understanding and research on PDVs, critically analysing the current challenges and highlighting the immense potential of PDVs as a novel class of therapeutics to treat human diseases. It is expected that this work will guide scientists to address the knowledge gaps currently associated with PDVs and promote new advances in plant‐based therapeutic solutions.

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“…Mineral malnutrition is unfortunately a common problem in both developing and industrialized countries, with estimates suggesting that up to two-thirds of the world's population may be at risk of deficiency in one or more critical mineral elements [135,136]. Nutrient deficiency is considered one of humanity's most severe concerns, from which millions of people suffer.…”

Section: Plant Nutrition Management For Human Healthmentioning

confidence: 99%

Plant Nutrition for Human Health: A Pictorial Review on Plant Bioactive Compounds for Sustainable Agriculture

et al. 2022

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Is there any relationship between plant nutrition and human health? The overall response to this question is very positive, and a strong relationship between the nutrition of plants and humans has been reported in the literature. The nutritional status of edible plants consumed by humans can have a negative or positive impact on human health. This review was designed to assess the importance of plant bioactive compounds for human health under the umbrella of sustainable agriculture. With respect to the first research question, it was found that plant bioactives (e.g., alkaloids, carotenoids, flavonoids, phenolics, and terpenoids) have a crucial role in human health due to their therapeutic benefits, and their potentiality depends on several factors, including botanical, environmental, and clinical attributes. Plant bioactives could be produced using plant tissue culture tools (as a kind of agro-biotechnological method), especially in cases of underexploited or endangered plants. Bioactive production of plants depends on many factors, especially climate change (heat stress, drought, UV radiation, ozone, and elevated CO2), environmental pollution, and problematic soils (degraded, saline/alkaline, waterlogged, etc.). Under the previously mentioned stresses, in reviewing the literature, a positive or negative association was found depending on the kinds of stress or bioactives and their attributes. The observed correlation between plant bioactives and stress (or growth factors) might explain the importance of these bioactives for human health. Their accumulation in stressed plants can increase their tolerance to stress and their therapeutic roles. The results of this study are in keeping with previous observational studies, which confirmed that the human nutrition might start from edible plants and their bioactive contents, which are consumed by humans. This review is the first report that analyzes this previously observed relationship using pictorial presentation.

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Plant Food, Nutrition, and Human Health

Abstract: Phytochemical compounds are non-nutrient secondary metabolites present in plant-based foods, e [...]

Cited by 19 publications

References 23 publications

Moringa oleifera Lam. in Diabetes Mellitus: A Systematic Review and Meta-Analysis

Moringa oleifera Lam. in Diabetes Mellitus: A Systematic Review and Meta-Analysis

Plant‐derived extracellular vesicles: Recent advancements and current challenges on their use for biomedical applications

Plant Nutrition for Human Health: A Pictorial Review on Plant Bioactive Compounds for Sustainable Agriculture

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