1993
DOI: 10.4269/ajtmh.1993.49.720
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Plasma Antioxidants and Lipid Peroxidation Products in Falciparum Malaria

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Cited by 66 publications
(39 citation statements)
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“…This was in consistency with other reported work where such similar rise in MDA in falciparum malaria has been attributed to be a measure of severity of tissue damage (6,(10)(11)(12). The assumption that serum MDA reflects the oxidative damage of tissues particularly in erythrocytes, which are in direct and continuous contact with plasma and in which the peroxide is generated as a result of oxidative stress perhaps, holds good for ARF patients in our study.…”
Section: Discussionsupporting
confidence: 81%
“…This was in consistency with other reported work where such similar rise in MDA in falciparum malaria has been attributed to be a measure of severity of tissue damage (6,(10)(11)(12). The assumption that serum MDA reflects the oxidative damage of tissues particularly in erythrocytes, which are in direct and continuous contact with plasma and in which the peroxide is generated as a result of oxidative stress perhaps, holds good for ARF patients in our study.…”
Section: Discussionsupporting
confidence: 81%
“…Vitamin E is the major chain terminating antioxidant in membranes; it reduces both conjugated dienyl and hydroperoxyl radicals, quenching the chain or cycle or lipid peroxidation reactions. Studies have demonstrated that lipid peroxide levels can reflect the severity of a disease process (Das, et al 1993) and increased MDA is an indicator of reactive oxygen species (ROS) generation in the tissue (Halliwell and Hutteridge, 1989).…”
Section: Resultsmentioning
confidence: 99%
“…Excess hydrogen peroxide could also results in break down of heme and release of free iron ions, which in turn form OH via Fenton reaction (20). Increased adenosine deaminase activity brings about increased xanthine oxidase activity thereby representing another source of superoxide anion formation (2).…”
Section: Ii) Enhancement Of Oxidant Status In Malaria Patientsmentioning
confidence: 99%
“…Besides this, the plasma of malaria patients has been suspected Indian Journal of Clinical Biochemistry, 2003 136-149 to contain prooxidants. Hemoglobin can act as prooxidant by catalyzing the decomposition of lipid hydropemxides enhancing the chain reaction (20).…”
Section: Ii) Enhancement Of Oxidant Status In Malaria Patientsmentioning
confidence: 99%