Plasma Cells in Chronic Endometritis are Easily Identified When Stained with Syndecan-1

Bayer‐Garner, Ilene B.; Korourian, Soheila

doi:10.1038/modpathol.3880405

Cited by 112 publications

(86 citation statements)

References 9 publications

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“…Immunostaining for syndecan-1 was detectable in the surface and glandular epithelium (6)(7)(8) in all samples examined, and immunostaining for control IgG was not detectable in any sample examined. According to punctate immunostaining for syndecan-1 in the stroma, chronic endometritis was diagnosed in 5 of 54 samples (9.3%).…”

mentioning

confidence: 80%

“…The prevalence of chronic endometritis in the general population is thereby elusive (5). Furthermore, chronic endometritis is prone to be missed in conventional histopathologic examinations, because endometrial stromal plasmacytes morphologically resemble fibroblasts and mononuclear cells (6,7). Thus, accurate diagnosis of chronic endometritis had been a challenge for both gynecologists and pathologists before heparan sulfate proteoglycan syndecan-1 was found to be a specific and sensitive antigen of endometrial stromal plasmacytes (7).…”

mentioning

confidence: 97%

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Prevalence of chronic endometritis in recurrent miscarriages

Kitaya¹

2011

Fertility and Sterility

116

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confidence: 80%

mentioning

confidence: 97%

Prevalence of chronic endometritis in recurrent miscarriages

Kitaya¹

2011

Fertility and Sterility

116

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“…Ready-to-use mouse monoclonal antibodies against human CD45 (leukocyte common antigen, 2B11), CD3 (T-cell marker, PS1), CD20 (B-cell marker, L26), CD56 (natural killer (NK) cell marker, 1B6), CD68 (macrophage marker, PG-M1), and syndecan-1 (plasmacyte marker, B-A38) 24 were obtained from Nichirei (Tokyo, Japan). Mouse monoclonal antineutrophil elastase antibody (NP57, 1:50 dilution) was obtained from Dako (Kyoto, Japan).…”

Section: Antibodies and Reagentsmentioning

confidence: 99%

Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis

2010

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Chronic endometritis is often identified in the patients with unexplained infertility, and is histopathologically characterized by infiltration of plasmacytes within the endometrial stroma. In parallel with stromal plasmacyte infiltration, the endometrial functional layer in chronic endometritis is invaded by B cells, which are a rare leukocyte subset residing within the basal layer in the nonpathological endometrium. In this study, we investigated the molecular expression underlying this unusual increase of B cells in chronic endometritis. Twenty-two out of 76 infertile patients were diagnosed with chronic endometritis from the stromal plasmacyte infiltration, and the endometrium contained numerous stromal B-cell aggregates and glandular single B cells. However, the other major leukocyte subsets, including T cells, natural killer cells, macrophages, and neutrophils were comparable in densities in chronic endometritis and nonpathological endometrium. The microvascular endothelium showed immunoreactivity to adhesion molecule selectin E and chemokine CXCL13 along with immunoreactivity to CXCL1 in the glandular epithelium in chronic endometritis, but not in the nonpathological endometrium. Lipopolysaccharide significantly induced surface selectin E expression and CXCL13 secretion in uterine microvascular endothelial cells, and CXCL1 secretion in endometrial epithelial cells in vitro. These findings indicated that the aberrant local microenvironment triggered possibly by bacterial infection has a role in selective extravasation of circulating B cells in chronic endometritis.

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“…Лимфоциты с фенотипом CD56 + являются разновидностью натуральных киллеров, и снижение их количества могло сви-детельствовать об уменьшении активности ХЭ. + лимфоцитов позволяет иденти-фицировать ХЭ [11]. Снижение количества плаз-матических клеток свидетельствовало о норма-лизации морфологии эндометрия.…”

Section: результаты и обсуждениеunclassified

Effects of Combined Physiotherapy in Chronic Endometritis: Dynamics of Inflammatory Activity

Плясунова¹,

Хлыбова²,

Феоктистов³

et al. 2015

Med.Imm.Rus

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) и антигена-HLA-DR с использованием моноклональных антител фирмы «Novocastrа» (Великобритания) в соскобах из полости матки у пациенток с верифи-цированным хроническим эндометритом (ХЭ) до и после лечения. Лечение ХЭ проводили по стан-дартным методикам, при этом в одной группе пациентов проводилась реабилитация с помощью КАП-ЭЛМ-01 «Андро-Гин», в другой группе для лечения использовалась заместительная гормональ-ная терапия и комплексное физиотерапевтическое лечение с помощью КАП-ЭЛМ-01 «Андро-Гин». Обнаружено достоверное снижения уровня цитотоксических лимфоцитов в соскобах из полости мат-ки после лечения. Ключевые слова: хронический эндометрит, цитотоксические лимфоциты, физиотерапия EFFECTS OF COMBINED PHYSIOTHERAPY IN CHRONIC ENDOMETRITIS: DYNAMICS OF INFLAMMATORY ACTIVITY

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Plasma Cells in Chronic Endometritis are Easily Identified When Stained with Syndecan-1

Cited by 112 publications

References 9 publications

Prevalence of chronic endometritis in recurrent miscarriages

Prevalence of chronic endometritis in recurrent miscarriages

Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis

Effects of Combined Physiotherapy in Chronic Endometritis: Dynamics of Inflammatory Activity

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