Plasma concentrations of 8-hydroxy-2′-deoxyguanosine and risk of kidney disease and death in individuals with type 1 diabetes

Sánchez, Manuel; Roussel, Ronan; Hadjadj, Samy; Moutairou, Abdul; Marre, Michel; Mohammedi, Kamel

doi:10.1007/s00125-017-4510-1

Cited by 39 publications

(38 citation statements)

References 39 publications

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“…We showed that increased oxidative damage in glomerular endothelial cells was also detected in human subjects diagnosed with DKD, and oxidized DNA lesion excretion in the urine (8-OHdG) was significantly increased only in patients with progressive DKD ( 42 ). In accordance with our data, higher plasma concentrations of 8-OHdG were found to be independently associated with increased risk of progression of kidney disease in T1DM ( 111 ). Altogether, there are convincing data showing that oxidative damage is context dependent in DKD and that the glomerular endothelium could be the weakest link under chronic stress, and suggests that podocyte depletion in DKD-susceptible mice could be contingent on endothelial cell mitochondrial dysfunction.…”

Section: The Ros Paradox In Dkdsupporting

confidence: 92%

Glomerular Endothelial Cell Stress and Cross-Talk With Podocytes in Early Diabetic Kidney Disease

Daehn

2018

Front. Med.

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Diabetic kidney disease (DKD) is one of the major causes of morbidity and mortality in diabetic patients and also the leading single cause of end-stage renal disease in the United States. A large proportion of diabetic patients develop DKD and others don’t, even with comparable blood glucose levels, indicating a significant genetic component of disease susceptibility. The glomerulus is the primary site of diabetic injury in the kidney, glomerular hypertrophy and podocyte depletion are glomerular hallmarks of progressive DKD, and the degree of podocyte loss correlates with severity of the disease. We know that chronic hyperglycemia contributes to both microvascular and macrovascular complications, as well as podocyte injury. We are beginning to understand the role of glomerular endothelial injury, as well as the involvement of reactive oxygen species and mitochondrial stress, which play a direct role in DKD and in other diabetic complications. There is, however, a gap in our knowledge that links genetic susceptibility to early molecular mechanisms and proteinuria in DKD. Emerging research that explores glomerular cell’s specific responses to diabetes and cell cross-talk will provide mechanistic clues that underlie DKD and provide novel avenues for therapeutic intervention.

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Section: The Ros Paradox In Dkdsupporting

confidence: 92%

Glomerular Endothelial Cell Stress and Cross-Talk With Podocytes in Early Diabetic Kidney Disease

Daehn

2018

Front. Med.

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“…This slightly significant increase in 8-OHdG with type 1 diabetic patients with normoalbuminuria compared with healthy subjects (control) indicated that type 1 causes damage (oxidation) to DNA of kidney cells before occurrence of albuminuria (nephropathy) and after occurance of albuminuria this increase in 8-OHdG is highly increased as indicated between macroalbuminuria (G4) compared with microalbuminuria (G3) and presence of highly significant positive correlation between AER and 8-OHdG in study groups (p value<0.05) .These results are in accordance with Ilse, 2018 and Qi H et al [3,13], they showed oxidative damage increase in endothelial cells of glomerulus detected in patients diagnosed with diabetic kidney disease (DKD), as oxidized DNA lesion excretion in the urine (8-OHdG) was significantly increased in patients with diabetic nephropathy progression, this is disagree with our results as they reported that this increase in 8-OhdG is only diabetic nephropathy progression and not with normoalbuminuria, but they estimated 8-OHdG in urine and we estimated it in serum, so we need more studies in this point and estimate 8-OHdG in both urine and serum samples together and correlate between them and confirm that this significant increase in patients with normoalbuminuria compared with healthy subjects founded in 8-OHdG results in serum, also found in urine or increase only in serum. Sanchez et al and Santosh et al [14,15] were also in agreement with our data, as higher concentrations of 8-OHdG were found to be associated with increased risk of progression of kidney disease in both T1DM and T2DM.…”

Section: Discussionsupporting

confidence: 93%

Assessment of 8-Hydroxy-2-Deoxyguanosine (8-OHdG) as a Diagnostic Marker for Diabetic Nephropathy in Type 1 Egyptian Diabetic Patients

Soliman¹,

Awad²,

Abdelghffar³

et al. 2019

J Diabetes Metab

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Aim of the work:To identify the relationship between serum concentration of 7,8-dihydro-2-deoxyguanosine (8-OHdG) and different stages of Albumin Excretion Rate (AER), as marker of nephropathy in Egyptian patients with Type 1 Diabetes(T1D). Subjects and methodology:Total 65 volunteers were distributed in 4 groups: group 1 included 20 healthy subjects as control, group 2: 15 T1D patients with AER<30 mg/g creatinine, group 3:15 T1D patients with (300 30 mg/g creatinine) and group 4:15 T1D patients with (AER>30 mg/g creatinine). The blood chemistry parameters were analyzed, glycated hemoglobin (HbA1c) and serum urea and creatinine, Malodialdhyde (MDA), 8-oxodG levels were measured by ELISA.Results: Significant increase in urea and creatinine in G3 and G4 with control with a p value<0.005. Also increase in 8-OHdG and MDA with a p value<0.005 in G2, G3 and G4 compared with control.

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“…The exact pathogenesis is complex and oxidative stress has a significant role in the pathogenesis of DN and its progression to ESRD. In recent years, a variety of biomarkers of oxidative stress associated with DN has been found and the most important ones used in clinical studies are presented ( Table 2 ) [ 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 ].…”

Section: Biomarkers Of Oxidative Stress In Development and Progresmentioning

confidence: 99%

“…In long-standing type 1 diabetic patients, higher plasma 8-OHdG levels were independently associated with increased risk of DN [ 177 ].…”

Section: Biomarkers Of Oxidative Stress In Development and Progresmentioning

confidence: 99%

Oxidative Stress Markers in Chronic Kidney Disease with Emphasis on Diabetic Nephropathy

et al. 2020

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Diabetes prevalence is increasing worldwide, especially through the increase of type 2 diabetes. Diabetic nephropathy occurs in up to 40% of diabetic patients and is the leading cause of end-stage renal disease. Various factors affect the development and progression of diabetic nephropathy. Hyperglycaemia increases free radical production, resulting in oxidative stress, which plays an important role in the pathogenesis of diabetic nephropathy. Free radicals have a short half-life and are difficult to measure. In contrast, oxidation products, including lipid peroxidation, protein oxidation, and nucleic acid oxidation, have longer lifetimes and are used to evaluate oxidative stress. In recent years, different oxidative stress biomarkers associated with diabetic nephropathy have been found. This review summarises current evidence of oxidative stress biomarkers in patients with diabetic nephropathy. Although some of them are promising, they cannot replace currently used clinical biomarkers (eGFR, proteinuria) in the development and progression of diabetic nephropathy.

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Plasma concentrations of 8-hydroxy-2′-deoxyguanosine and risk of kidney disease and death in individuals with type 1 diabetes

Abstract: Higher plasma concentrations of 8-OHdG were independently associated with increased risk of kidney disease in individuals with type 1 diabetes, suggesting that this marker can be used to evaluate the progression of diabetic kidney disease.

Cited by 39 publications

References 39 publications

Glomerular Endothelial Cell Stress and Cross-Talk With Podocytes in Early Diabetic Kidney Disease

Glomerular Endothelial Cell Stress and Cross-Talk With Podocytes in Early Diabetic Kidney Disease

Assessment of 8-Hydroxy-2-Deoxyguanosine (8-OHdG) as a Diagnostic Marker for Diabetic Nephropathy in Type 1 Egyptian Diabetic Patients

Oxidative Stress Markers in Chronic Kidney Disease with Emphasis on Diabetic Nephropathy

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