Plasma Cytokine Levels in Migraineurs and Controls

Perini, Francesco; D’Andrea, Giovanni; Galloni, Elisabetta; Pignatelli, Francesco; Billo, Giuseppe; Alba, Sabrina; Bussone, Gennaro; Toso, V.

doi:10.1111/j.1526-4610.2005.05135.x

Cited by 268 publications

(224 citation statements)

References 25 publications

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“…A high level of pro-inflammatory cytokines including IL-1β in patients with migraines had been described [12]. This may be relevant to understand the physiopathological mechanism of headaches in CAPS and can explain canakinumab efficacy which was complete for 2 of 4 patients with migrainous headaches.…”

Section: Migrainous Headaches 4 27mentioning

confidence: 93%

Neurological outcome of patients with cryopyrin-associated periodic syndrome (CAPS)

Mamoudjy¹,

Maurey

Marié

et al. 2017

European Journal of Paediatric Neurology

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Section: Migrainous Headaches 4 27mentioning

confidence: 93%

Neurological outcome of patients with cryopyrin-associated periodic syndrome (CAPS)

Mamoudjy¹,

Maurey

Marié

et al. 2017

European Journal of Paediatric Neurology

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“…Kemper, Meijler, Korf and Ter Horst (2001) reviewed the literature up to 1999 and concluded that there was no evidence for a well-defined disorder immunological disorder in migraine, due to methodological limitations of the available results. More recent studies have however suggested a role of the immune system, in particular inflammatory cytokines, in migraine (Perini et al, 2005;Bruno, 2007;Bockowski, Sobaniec and Zelazowska-Rutowska, 2009;Yilmaz et al, 2010). Carmichael and Simner (2013) also proposed that cytokines might play a role in synaesthesia.…”

Section: The Immune Hypothesis Of Synaesthesiamentioning

confidence: 99%

Migraine in Synesthetes and Nonsynesthetes: A Prevalence Study

Jonas

Hibbard

2015

Perception

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Synaesthesia is a neurological condition in which an inducer stimulus in one sense leads to a concurrent percept in a second sense. The immune hypothesis of synaesthesia links synaesthesia to immune-related conditions such as migraine. More specifically, migraine with aura may be linked to grapheme-colour synaesthesia as both involve cortical hyperexcitability. In this study, 188 synaesthetes and 121 non-synaesthetes completed an online questionnaire about synaesthesia and migraine. We found no general link between migraine and synaesthesia, nor between migraine with aura and grapheme-colour synaesthesia. Exploratory analyses, however, showed that certain types of synaesthetic inducer (significant: scent, emotion, and personality; trends: pain, non-lexical visual experiences, taste, and touch) were associated with visual disturbances in headache among female participants. Based on our exploratory analyses we hypothesise that specific subtypes of synaesthesia are related to migraine. The relationship between these two conditions is likely to become clearer as research on the underlying causes of synaesthesia and migraine progresses.

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“…19,20 Studies support the involvement of proinflammatory cytokines (especially TNF) in migraine. 21,22 Our earlier study revealed a relationship between TNFRSF1B polymorphism and an augmented risk of migraine.…”

Section: Discussionmentioning

confidence: 99%

Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population

et al. 2015

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Objective: To investigate the correlation between migraine in a Chinese population and a 4 base pair (GAGT) insertion/deletion polymorphism (rs35975099) localized near the 3' end of the tumour necrosis factor superfamily 10 gene, TNFSF10. Methods: Ethnically Han Chinese patients with migraine and healthy control subjects were recruited. TNFSF10 genotype and allele frequencies were determined via polymerase chain reaction and polyacrylamide gel electrophoresis. Results: Rs35975099 was in Harvey-Weinberg equilibrium in patients with migraine (n ¼ 269) and control subjects (n ¼ 374). There were no significant relationships between allele or genotype frequency and migraine. Conclusion: There was no functional significance of the TNFSF10 gene polymorphism rs35975099 in migraine pathogenesis.

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Plasma Cytokine Levels in Migraineurs and Controls

Abstract: Our results suggest that TNFalpha, IL-1 beta, and IL-10 may be involved in the pathogenesis of migraine attacks.

Cited by 268 publications

References 25 publications

Neurological outcome of patients with cryopyrin-associated periodic syndrome (CAPS)

Neurological outcome of patients with cryopyrin-associated periodic syndrome (CAPS)

Migraine in Synesthetes and Nonsynesthetes: A Prevalence Study

Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population

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