Plasma disposition of flumequine in common carp (Cyprinus carpio L., 1758), African catfish (Clarias gariepinus Burchell, 1822) and European eel (Anguilla anguilla L., 1758) after a single peroral administration

Heijden, M.H.T. van der; Keukens, H.J.; Nieuwboer, W.H.F.X. van den; Mengelers, Marcel; Boon, J.H.

doi:10.1016/0044-8486(94)90116-3

Cited by 28 publications

(18 citation statements)

References 9 publications

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“…In the following discussion, the results refer to the orally administrated fish unless otherwise specified. The elimination half-lives estimated from the LSC of blood (intravenously administered fish) are in the same range as reported from other flumequine studies in the same species (Boon et al 1991, van der Heijden et al 1994, Samuelsen & Ervik 1997, Hansen & Horsberg 1999, 2000a. Turbot seem to have elimination halflives in the same range as Atlantic salmon Salmo salar, which have been reported to have elimination halflives of 29 to 40 h (Rogstad et al 1993, Elema et al 1995.…”

Section: Discussionsupporting

confidence: 68%

“…In eel Anguilla anguilla, van der Heijden et al (1993) found a higher muscle:plasma ratio (0.99 at 48 h) than our muscle:blood ratio, a lower liver: plasma ratio, and significantly lower kidney:plasma and skin:plasma ratios at 48 h, than observed in our study. The eel used in the study of van der Heijden et al (1993) were approximately 470 versus 100 g in our study, and the flumequine was administered intramuscularly. Difference in size, nutritional status and the different way of administration may have contributed to these discrepancies.…”

Section: Skin Eye Bilecontrasting

confidence: 56%

“…The radioactivity observed represents the total flumequine residue level consisting of both parent compound and metabolites. Several studies have shown that metabolism of flumequine in various fish species appears to be slow with low levels of metabolites being detected (van der Heijden et al 1993, 1994, Samuelsen & Ervik 1997, Plakas et al 2000. With the exception of bile and urine, the total flumequine residues shown in WBA and measured by LSC in this study, therefore most likely to a large extent represent the parent compound.…”

Section: +mentioning

confidence: 90%

“…Difference in size, nutritional status and the different way of administration may have contributed to these discrepancies. Eel muscle may contain more than 30% fat, and van der Heijden et al (1993) found high levels of flumequine in fat.…”

Section: Skin Eye Bilementioning

confidence: 99%

“…The affinity of flumequine for skin can be explained by melanin's capacity to bind drugs (Potts 1963, Ullberg et al 1970, Lindquist & Ullberg 1972, Larsson 1993, Fukuda & Sasaki 1994, Howells et al 1994, Salazarbookaman et al 1994. Several studies have reported residues of flumequine and other fluoroquinolones in bone and skin for a long time after the level is below detection in plasma/muscle (Steffenak et al 1991, van der Heijden et al 1993, Elema et al 1994, Martinsen et al 1994.…”

Section: Skin Eye Bilementioning

confidence: 99%

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Disposition of 14C-flumequine in eel Anguilla anguilla, turbot Scophthalmus maximus and halibut Hippoglossus hippoglossus after oral and intravenous administration

Hansen

Ingebrigtsen²,

Wl³

et al. 2001

Dis. Aquat. Org.

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The absorption, distribution and elimination of 14 C-labelled flumequine were studied using whole body autoradiography and liquid scintillation counting. Flumequine was administered to eel Anguilla anguilla, turbot Scophthalmus maximus and halibut Hippoglossus hippoglossus intravenously and orally as a single dose of 5 mg kg . The turbot and halibut studies were performed in salt water (salinity of 32 ‰) at temperatures of 16 ± 1°C (turbot) and 9.5 ± 0.5°C (halibut). The eel study was conducted in fresh water at 23 ± 1°C. In the intravenously administered groups flumequine was rapidly distributed to all major tissues and organs. After oral administration flumequine also appeared to have rapid and extensive absorption and distribution in all 3 species. After the distribution phase, the level of flumequine was higher in most organs and tissues than in the blood, except in muscle and brain. The most noticeable difference between the species was the slow elimination of flumequine from eel compared to turbot and halibut. In orally administered eels, substantial amounts of flumequine remained in all major organs/tissues for 7 d. At 28 d significant levels of flumequine were present in liver, kidney and skin (with traces in muscle), and at the last sampling point (56 d) in eye, bone, bile and posterior intestine. In orally administered turbot significant levels of flumequine were observed over 96 h in bile, urine, bone, skin, intestine and eye, and traces were detected over 28 d in bone and eye in addition to a significant level in bile. In orally administered halibut, significant levels of flumequine were observed in bile, skin, intestine and eye over 96 h. Traces were present in skin and eye over 7 d. The maximal flumequine concentrations in blood were calculated to be 2.5 mg equivalents l -1 (eel at 12 h), 0.8 mg l -1 (turbot at 6 h) and 0.6 mg l -1 (halibut at 6 h) after oral administration.

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Section: Discussionsupporting

confidence: 68%

Section: Skin Eye Bilecontrasting

confidence: 56%