Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test

Sugiyama, Tetsuya; Oku, Hidehiro; Harino, Seiyo; Ikeda, Tsunehiko

doi:10.1007/s00417-006-0525-x

Cited by 8 publications

(10 citation statements)

References 15 publications

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“…Kida et al examined optic nerve head (ONH) blood circulation during 75-gr OGTT. They concluded that ONH circulation decreased in the abnormal glucose tolerance group, attributed partly to the increased endothelin-1 [ 24 ]. In a similar study, authors investigated the microcirculation and progression of macular edema [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Macular Peripapillary Nerve Fiber Layer and Choroidal Thickness Changes in Pregnant Women with Gestational Diabetes Mellitus, Healthy Pregnant Women, and Healthy Non-Pregnant Women

et al. 2015

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BackgroundGestational diabetes mellitus (GDM) is a risk factor for the development of type II diabetes and it causes maternal and child morbidity. Screening for diabetic retinopathy (DR) is important because patients who develop DR have no symptoms until macular edema and/or proliferative diabetic retinopathy (PDR) are already present. The aim of this study was to determine the early retinal findings of GDM.Material/MethodsThis study was conducted in a tertiary research center. We conducted a prospective cross-sectional study with 3 groups: Group 1 consisted of 36 pregnant women with GDM, Group 2 consisted of 24 healthy pregnant women, and Group 3 consisted of 38 healthy non-pregnant women of reproductive age. Spectralis optical coherence tomography (OCT) was used for the assessment. Macular, choroid, and retinal nerve fiber layer (RNFL) thicknesses were evaluated in patients with GDM and comparisons were made among pregnant women with GDM, healthy pregnant women, and healthy non-pregnant women for these parameters.ResultsThe nasal part of the RNFL was significantly thinner in the GDM group than in the healthy pregnant group. None of the patients had retinopathy or macular edema at the time of examination.ConclusionsDecreased nasal part of RNFL thickness may be the first retinal change in patients with GDM. Our study suggests that OCT should be performed for the patients with GDM for detection of early retinal changes associated with GDM.

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Section: Discussionmentioning

confidence: 99%

Assessment of Macular Peripapillary Nerve Fiber Layer and Choroidal Thickness Changes in Pregnant Women with Gestational Diabetes Mellitus, Healthy Pregnant Women, and Healthy Non-Pregnant Women

et al. 2015

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“…Before starting the measurement, a rest period of 5–10 mins should be scheduled in order to obtain stable systemic haemodynamic conditions, which should be verified by repeated measurements of systemic blood pressure and pulse rate. In addition, as a rise in blood glucose has been reported to increase ONH blood flow (Kida et al. 2001, 2007), clinical studies should be performed after a 2‐hour fasting period and a 6‐hour period of abstinence from coffee and alcohol.…”

Section: Clinical Protocolmentioning

confidence: 99%

“…2002), dynamic exercise (Okuno et al. 2006), glucose loading (Kida et al. 2007), various topical drugs (Tamaki et al.…”

Section: Reportingmentioning

confidence: 99%

Use of laser speckle flowgraphy in ocular blood flow research

Sugiyama

Araie

Riva

et al. 2009

Acta Ophthalmologica

Self Cite

354

314

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ABSTRACT.Laser speckle flowgraphy (LSFG) allows for the quantitative estimation of blood flow in the optic nerve head, choroid, retina and iris in vivo. It was developed to facilitate the non-contact analysis of ocular blood flow in living eyes, utilizing the laser speckle phenomenon. The technique uses a fundus camera, a diode laser, an image sensor, an infrared charge-coupled device (CCD) camera and a high-resolution digital CCD camera. Normalized blur (NB), an approximate reciprocal of speckle contrast, represents an index of blood velocity, and shows a good correlation with tissue blood flow rates determined with the microsphere method in the retina, choroid or iris, as well as blood flow rates determined with the hydrogen gas clearance method in the optic nerve head. The square blur ratio (SBR), another index for quantitative estimation of blood velocity, is proportional to the square of the NB. The SBR is theoretically a more exact measurement which is proportional to velocity, whereas the NB is an approximation. Normalized blur was calculated in earlier versions of LSFG because of technical limitations; the SBR is used in current versions of the LSFG instrument. As these values are in arbitrary units, they should not be used to make comparisons between different eyes or different sites in an eye. Clinical protocols, calibration, evaluation procedures and possible limitations of the LSFG technique are described and the results of ocular blood flow studies using LSFG are briefly summarized. The LSFG method is suitable for monitoring the time-course of change in the tissue circulation at the same site in the same eye at various intervals, ranging from seconds to months. Unresolved issues concern the effect of pupil size on measurement results, the effects of various stimulations, and how to measure choroidal and retinal blood flow velocity separately without using the blue-component of argon laser.

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“…Kida et al examined optic nerve head (ONH) blood circulation during 75-gr OGTT and concluded that ONH circulation decreased in the abnormal glucose tolerance group, attributed partly to the increased endothelin-1. 21 The significant positive correlation of GTT fasting and 1 hour values reflect the need for performing OCT along with glucose tolerance test as this helps in preventing early neurodegenerative changes occurring in RNFL. Thus uncontrolled blood sugar values brings about changes in the retinal microcirculation which causes thinning at the level of peripapillary optic nerve head or vice versa as evidence suggests that neurodegenerative changes occur prior to microvascular changes in diabetes.…”

Section: Comparison Of Blood Glucose Levels With Retinal Thinningmentioning

confidence: 99%

RNFL variation in gestational diabetes mellitus: An optical coherence tomography based study

Sasikumar¹,

Kakknatt²,

Mathai³

2020

IJCEO

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To study RNFL thickness in gestational diabetes mellitus based on OCT measurements. Methods: Case-control study with Inclusion criteria: 2groups of age 18-40yrs at 32-34weeks gestation Group 1: Healthy pregnant women Group 2: Pregnant women with GDM Exclusion Criteria: Preexisting hypertension/retinal diseases/renal disease/vascular disease/glaucoma/IOP>21mmHg/cataract/ refractive error correction more than or equal to +/-5D (spherical) or +/-3D (cylinder). Grouping-Study Design: more than 2 unrelated group study. Sample Size: n=182 Procedure: After detailed history taking &.written consent detailed ophthalmic examination is done Patients are classified into group1&2. Using CIRRUS HD OCT peripapillary RNFL is measured in superior, inferior, nasal and temporal fields. Results: Peripapillary RNFL showed significant thinning in GDM patients when compared to healthy pregnant female Conclusion: Peripapillary RNFL thinning in GDM patients measured in their third trimester suggest a neurodegenerative process preceding microvascular changes in gestational diabetes mellitus. The degree of retinal thinning at the level of macula correlated with the glycemic status of the patients. Thereby making it mandatory to carry out routine evaluation of retina with the help of OCT in all GDM patients to detect early neurodegenerative changes and to keep the blood glucose levels in normal range to prevent the occurrence of diabetic retinopathy.

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Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test

Abstract: ONH circulation increased after glucose intake in the normal glucose tolerance group and remained high even after the blood glucose level had returned to its baseline. The decrease in ONH circulation in the abnormal glucose tolerance group was attributed partly to the increased ET-1.

Cited by 8 publications

References 15 publications

Assessment of Macular Peripapillary Nerve Fiber Layer and Choroidal Thickness Changes in Pregnant Women with Gestational Diabetes Mellitus, Healthy Pregnant Women, and Healthy Non-Pregnant Women

Assessment of Macular Peripapillary Nerve Fiber Layer and Choroidal Thickness Changes in Pregnant Women with Gestational Diabetes Mellitus, Healthy Pregnant Women, and Healthy Non-Pregnant Women

Use of laser speckle flowgraphy in ocular blood flow research

RNFL variation in gestational diabetes mellitus: An optical coherence tomography based study

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