1999
DOI: 10.1542/peds.103.5.e69
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Plasma Insulin-like Growth Factor-1, Type 1 Procollagen, and Serum Tumor Necrosis Factor α in Children Recovering FromTrichuris Dysentery Syndrome

Abstract: These findings may contribute to the understanding of growth failure in children affected by other forms of chronic inflammatory bowel disease.

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Cited by 17 publications
(9 citation statements)
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“…[10][11][12][13] Severe stunting and clubbing of fingers in TDS have been attributed to increased tumor necrosis factor a and other cytokines in the lamina propria of the colonic mucosa and peripheral blood, decreased plasma insulinlike growth factor I, and decreased collagen synthesis. 3,14,15 Most investigators believe that the overall impact of trichuriasis on the health of children in endemic regions has been underestimated. TDS constitutes an important public health problem in children in endemic areas.…”
mentioning
confidence: 99%
“…[10][11][12][13] Severe stunting and clubbing of fingers in TDS have been attributed to increased tumor necrosis factor a and other cytokines in the lamina propria of the colonic mucosa and peripheral blood, decreased plasma insulinlike growth factor I, and decreased collagen synthesis. 3,14,15 Most investigators believe that the overall impact of trichuriasis on the health of children in endemic regions has been underestimated. TDS constitutes an important public health problem in children in endemic areas.…”
mentioning
confidence: 99%
“…24 Dari suatu penelitian terhadap 14 anak usia sekolah dasar dengan sindrom disentri trikuris, didapatkan kadar plasma insulin like growth factor (IGF)-1 rendah, kadar serum tumor necrosis factor a (TNF) meningkat, serum albumin normal, konsentrasi rerata hemoglobin rendah, sintesis kolagen menurun. 25 Secara keseluruhan infeksi Trichuris trichiura dapat menyebabkan diare kronik berat, serta hilangnya darah dalam jumlah besar, pernah dilaporkan kadar hemoglobin mencapai 3 gr/dl pada seorang pasien, 20 menyebabkan plasma IGF-1 menurun, kadar TNF a meningkat dan sintesis kolagen menurun. 25 Disamping itu umur Trichuris trichiura relatif panjang (10 tahun), 3,14 semua keadaan ini secara tidak langsung akan mengakibatkan gangguan pertumbuhan pada anak.…”
Section: Pengaruh Infeksi Trichuris Trichiuraunclassified
“…25 Secara keseluruhan infeksi Trichuris trichiura dapat menyebabkan diare kronik berat, serta hilangnya darah dalam jumlah besar, pernah dilaporkan kadar hemoglobin mencapai 3 gr/dl pada seorang pasien, 20 menyebabkan plasma IGF-1 menurun, kadar TNF a meningkat dan sintesis kolagen menurun. 25 Disamping itu umur Trichuris trichiura relatif panjang (10 tahun), 3,14 semua keadaan ini secara tidak langsung akan mengakibatkan gangguan pertumbuhan pada anak.…”
Section: Pengaruh Infeksi Trichuris Trichiuraunclassified
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“…(31,38) The nematode, Trichuris trichiura (whipworm) causes anaemia if the worm burden is heavy (31) and colonic lesions are associated with bleeding or there is a chronic reduction in food and micro-nutrient intake caused by anorexia-inducing effects of tumor necrosis factor-α released in response to the infection. (39)(40) …”
Section: Parasitic Infestationmentioning
confidence: 99%