Plasma Levels of C-Telopeptide Pyridinoline Cross-Links of Type I Collagen and Osteocalcin in Chronic Periodontitis

Abstract

This study was planned to investigate whether chronic periodontitis patients exhibit different plasma concentrations of C-telopeptide pyridinoline cross-links of type I collagen (ICTP) and osteocalcin (OC) compared to the clinically healthy controls. Before initiation of any periodontal intervention, plasma samples and full-mouth clinical periodontal recordings were obtained from 58 otherwise healthy patients with chronic periodontitis and also from 47 systemically and periodontally healthy control subjects. Plasma ICTP levels were determined by radioimmunoassay and OC levels by enzyme-linked immunosorbent assay. Data were tested statistically using t test and ANOVA. The healthy control group exhibited significantly lower values in all clinical periodontal measurements (P < 0.001). There were no significant differences between the study groups in plasma ICTP and OC levels (P > 0.05). Within the limits of this study, it may be suggested that plasma levels of ICTP and OC may not provide distinguishing data between chronic periodontitis patients and clinically healthy subjects.

Host‐derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis

“…Increased serum levels of IL‐1 β , TNF, OC, soluble intercellular adhesion molecule (sICAM), IL‐6, MMP‐9 have been reported in experimental studies in animal models as well as in clinical studies in humans (Raunio et al 2007, Guentsch et al 2009, Nakajima et al 2010). However, Özçaka et al (2010) failed to find significant differences between chronic periodontitis patients and healthy control subjects in terms of plasma OC and ICTP concentrations. In an intervention study, Marcaccini et al (2009) reported that chronic periodontitis patients had higher plasma concentrations of MMP‐3, ‐8, ‐9, and gelatinolytic activity, whereas non‐surgical periodontal treatment decreased their levels significantly.…”

“…Yoshihara et al (2009) reported that serum OC levels correlated with CAL in elderly Japanese subjects. On the other hand, indifferent plasma levels of ICTP and OC were reported in a recent study comparatively evaluating chronic periodontitis patients and healthy control subjects (Özçaka et al 2010). There is no consensus, yet on the potential usage of OC for assessment of periodontal diagnosis and prognosis.…”

BIO-Modulation Effect Of Low Intensity Laser as an Adjunct to Mechanical Debridement of Periodontitis

“…As regard to gingival crevicular fluid (GCF) analysis to assess the Osteocalcin bone hormone which is the most important biomarkers which is play a major role in the periodontitis (26) . So the present study select osteocalcin as a biochemical marker to detect the response of periodontitis to treatment with conventional scaling and root planning compared with conventional scaling and root planning and laser decontamination and low level laser biostimulation (27) .…”

Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor‐α in children

“…However, results from a case–control study indicated that plasma OC did not distinguish between chronic periodontitis patients and clinically healthy subjects (Özçaka et al. ). Nonetheless, the latter study (Özçaka et al.…”

“…Nonetheless, the latter study (Özçaka et al. ) included only periodontally healthy subjects (no gingivitis no periodontitis) in their control group, whereas the others (Yoshihara et al. , , , Lappin et al.…”