Plasma levels of neuroexcitatory amino acids in patients with migraine or tension headache

Alam, Z; Coombes, Nicholas; Waring, R. H.; Williams, Adrian; Steventon, Glyn B.

doi:10.1016/s0022-510x(98)00023-9

Cited by 84 publications

(61 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In blood from interictal episodic migraine patients the pooled difference was not statistically significant (SMD: 1.08, 95% CI: -0.07, 2.22) (56)(57)(58)(59)(60)(61)(62). After exclusion of paediatric migraine patients (58), glutamate concentrations were increased in the (24).…”

Section: Glutamate (Figure 2)mentioning

confidence: 84%

Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis

et al. 2016

View full text Add to dashboard Cite

Objective: To perform a meta-analysis of migraine biomarkers in cerebrospinal fluid (CSF) and of corresponding blood concentrations. Methods: We conducted a systematic search for studies that measured biochemical compounds in CSF of chronic or episodic migraineurs and non-headache controls. Subsequent searches retrieved studies with blood measurements of selected CSF biomarkers. If a compound was assessed in three or more studies, results were pooled in a meta-analysis with standardised mean differences (SMD) as effect measures. Results: Sixty-two compounds were measured in 40 CSF studies. Most important results include: increased glutamate (five studies, SMD 2.22, 95% CI: 1.30, 3.13), calcitonin gene-related peptide (CGRP) (three studies, SMD: 3.80, 95% CI: 3.19, 4.41) and nerve growth factor (NGF) (three studies, SMD: 6.47, 95% CI: 5.55, 7.39) in chronic migraine patients and decreased b-endorphin (b-EP) in both chronic (four studies, SMD: -1.37, 95% CI: -1.80, -0.94) and interictal episodic migraine patients (three studies, SMD: -1.12, 95% CI: -1.65, -0.58). In blood, glutamate (interictal) and CGRP (chronic, interictal and ictal) were increased and b-EP (chronic, interictal and ictal) was decreased. Conclusions: Glutamate, b-EP, CGRP and NGF concentrations are altered in CSF and, except for NGF, also in blood of migraineurs. Future research should focus on the pathophysiological roles of these compounds in migraine.

show abstract

Section: Glutamate (Figure 2)mentioning

confidence: 84%

Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…12 It is known that migraine is characterized by a state of central neuronal hyperexcitability, 30 which involves overactivity of the excitatory amino acids. Higher concentrations of excitatory amino acids (mainly glutamic and aspartic acid) were observed in the cerebrospinal fluid, 23 in the saliva, 26 in the plasma, 2,13 and in the platelets 9 of patients with migraine.…”

mentioning

confidence: 94%

Indomethacin, alone and combined with prochlorperazine and caffeine, but not sumatriptan, abolishes peripheral and central sensitization in in vivo models of migraine

Ghelardini

Galeotti

Grazioli

et al. 2004

The Journal of Pain

View full text Add to dashboard Cite

M igraine is a common, multifactorial, neurovascular disorder, characterized by recurrent disabling attacks of moderate to severe headache, nausea, vomiting, photophobia, and phonophobia, and also, in up to one third of patients, neurologic aura symptoms. 12 It is known that migraine is characterized by a state of central neuronal hyperexcitability, 30 which involves overactivity of the excitatory amino acids. Higher concentrations of excitatory amino acids (mainly glutamic and aspartic acid) were observed in the cerebrospinal fluid, 23 in the saliva, 26 in the plasma, 2,13 and in the platelets 9 of patients with migraine.Recently it has been proposed that the throbbing pain of migraine, which is the pulsating pain aggravated by routine physical activities, is mediated by sensitization of peripheral trigeminovascular neurons, and that cutaneous allodynia (CA) of migraine, which means pain resulting from a non-noxious stimulus to normal skin, is mediated by sensitization of central trigeminovascular neurons. 4,22 The development of hyperalgesia has been shown after the injection of kainic acid. The hyperalgesic effect of kainic acid appears to be mediated by activity at aminomethylisoxazole-propionic acid/kainate receptors that are located outside the spinal cord, perhaps on primary afferents in trigeminal ganglia. 27 Intraperitoneal injection of kainic acid induces a persistent hyperalgesia in mice and rats. 18 Glutamate, an excitatory neurotransmitter, produces

show abstract

“…During migraine and alzaymer total plasma thiols, L-cysteic acid was found to be high [8,9]. To date, several methods such as gas chromatography [10] and HPLC [11] have been used for determination of L-cysteic acid in various samples.…”

Section: Introductionmentioning

confidence: 99%

<b>Voltammetric determination of l-cysteic acid on a 1-[4-(ferrocenyl-ethynyl)phenyl]-1-ethanone modified carbon paste electrode</b>

Raoof

Ojani

Karimi‐Maleh

2008

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

ABSTRACT. The electrochemical behaviour of L-cysteic acid was studied at the surface of 1-[4-(ferrocenylethynyl)phenyl]-1-ethanone modified carbon paste electrode (4FEPEMCPE) in aqueous media using cyclic voltammetry and double step potential chronoamperometry. It has been found, that under optimum condition (pH 7.00) in cyclic voltammetry, the oxidation of L-cysteic acid at the surface of 4FEPEMCPE is occurred at a potential about 220 mV less positive than that an unmodified carbon paste electrode. The kinetic parameters such as electron transfer coefficient, α, and catalytic reaction rate constant, K / h, were also determined using electrochemical approaches. The electrocatalytic oxidation peak current of L-cysteic acid showed a linear dependent on the L-cysteic acid concentration and linear calibration curves were obtained in the ranges of 9 × 10 -5 -6.2 × 10 -3 M and 2.0 × 10 -7 -1.17 × 10 -5 M of L-cysteic acid concentration with cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods, respectively. The detection limits (3σ) were determined equal to 2.3 × 10 -5 M and 8.7 × 10 -8 M by CV and DPV methods. This method was also examined as a selective, simple and precise new method for voltammetric determination of L-cysteic acid in serum of patient's blood with migraine disease.

show abstract

Plasma levels of neuroexcitatory amino acids in patients with migraine or tension headache

Cited by 84 publications

References 17 publications

Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis

Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis

Indomethacin, alone and combined with prochlorperazine and caffeine, but not sumatriptan, abolishes peripheral and central sensitization in in vivo models of migraine

<b>Voltammetric determination of l-cysteic acid on a 1-[4-(ferrocenyl-ethynyl)phenyl]-1-ethanone modified carbon paste electrode</b>

Contact Info

Product

Resources

About