2016
DOI: 10.1177/1535370216659946
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Plasma lipid levels predict dysglycemia in a biracial cohort of nondiabetic subjects: Potential mechanisms

Abstract: Dyslipidemia and dysglycemia are etiologically associated, but the direction, chronology, and mechanisms of the association are not fully understood. We, therefore, analyzed data from 335 healthy adults (184 black, 151 white) enrolled in the Pathobiology of Prediabetes in A Biracial Cohort study. Subjects underwent oral glucose tolerance test (OGTT) and were enrolled if they had normal fasting and 2-h plasma glucose levels. Assessments during year 1 included anthropometry, fasting lipid profile, insulin sensit… Show more

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Cited by 23 publications
(18 citation statements)
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“…Our findings are in partial accordance with earlier findings in a cohort study conducted in Memphis, USA on white and black offspring of parents with T2DM, to investigate whether individual lipid moieties at baseline had congruent relationships with glycemia, and adiposity as well as insulin sensitivity and insulin secretion. 37 In this American study higher baseline plasma levels of cholesterol, LDL-C, and triglycerides significantly increased the risk of incident prediabetes/ T2DM, indicating that dyslipidemia preceded dysglycemia. Therefore, it was concluded that among healthy offspring of parents with T2DM, baseline lipid profiles predicted incident prediabetes/T2DM.…”
Section: Discussionmentioning
confidence: 62%
See 1 more Smart Citation
“…Our findings are in partial accordance with earlier findings in a cohort study conducted in Memphis, USA on white and black offspring of parents with T2DM, to investigate whether individual lipid moieties at baseline had congruent relationships with glycemia, and adiposity as well as insulin sensitivity and insulin secretion. 37 In this American study higher baseline plasma levels of cholesterol, LDL-C, and triglycerides significantly increased the risk of incident prediabetes/ T2DM, indicating that dyslipidemia preceded dysglycemia. Therefore, it was concluded that among healthy offspring of parents with T2DM, baseline lipid profiles predicted incident prediabetes/T2DM.…”
Section: Discussionmentioning
confidence: 62%
“…Many previous studies [34][35][36] investigated the association of dyslipidemia and prediabetes, and the presence of dyslipidemia has been reported to be associated with increased risk of progression of prediabetes to full type 2 diabetes (T2DM), 37,38 as well as rapid development and advanced stages of diabetic complications. 35,39,40 In our study, a statistically significant association of prediabetes with all lipid parameters was noted in univariate analyses, similar to what was reported earlier in other populations, 34,36 but neither of these studies performed regression analysis.…”
Section: Discussionmentioning
confidence: 99%
“…Of the studies using intravenous stimulation ( n = 27), some studies employed multiple methods within the same study, most commonly the insulin-modified IVGTT ( n = 15) [27, 3639, 4345, 49, 5154, 56, 58]. Studies also employed the nonmodified IVGTT ( n = 6) [33, 46, 5962], the tolbutamide-modified IVGTT ( n = 4) [43, 44, 51, 63], the hyperglycaemic clamp ( n = 4) [30, 47, 64, 65], and the arginine-stimulated response ( n = 2) [47, 60]. One study [25] used combined tolbutamide and glucagon intravenous stimulation.…”
Section: Resultsmentioning
confidence: 99%
“…Reports from the POP-ABC Study have identified several predictors of progression from NGR to incident prediabetes in a diverse cohort. [15][16][17][18][19][20] The 5-year extension study, PROP-ABC, was initiated in October 2013, and re-enrolled 223 of the original POP-ABC participants. The overall objectives of the PROP-ABC Study were to gain a fuller understanding of the natural history and predictors of early glucose abnormalities, determine the role of race/ethnicity, and to assess the reversibility of prediabetes.…”
Section: Introductionmentioning
confidence: 99%