Plasma Lipidomic Profile Signature of Hypertension in Mexican American Families

Egan, Brent M.

doi:10.1161/hypertensionaha.113.01633

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…In the liver, phosphatidylcholine (PC) emulsifies TG, promotes TG metabolism, and decreases hepatic deposition of TG. [41,42] Thus, the accumulation of lipids in the liver in the MC group might have been associated with the down-regulation of PC expression. TG accumulation in non-adipose tissues and the formation of lipid droplets are a sign of lipotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut‐Liver Axis in Diet‐Induced High‐Fat Mesocricetus auratus through Multiple Integrated Omics

Zeng

Chen

Wang

et al. 2023

Molecular Nutrition Food Res

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Scope Hyperlipidemia is currently a global public health problem severely affecting people's physical and mental health, as well as their quality of life. Methods and results The present study is aimed at revealing the mechanism of Porphyra haitanensis polysaccharide (PHP) in decreasing blood lipids by acting through gut‐liver axis in Mesocricetus auratus fed a high‐fat diet. PHP significantly prevented increases in serum total cholesterol, triglycerides and low‐density lipoprotein cholesterol, and alleviated damage to liver cells induced by a high‐fat diet M. auratus, in a dose‐dependent manner. PHP promotes proliferation of Muribaculaceae and Faecalibaculum, thereby enhancing the production of butyric acid both in the colon and liver, particularly high‐dose PHP (HPHP). Low‐dose PHP (LPHP) promotes the expression of phosphatidylcholine metabolites and fatty acid transport genes, and inhibits the expression of genes involved in fat degradation (Abhd5), adipogenesis (Me1), fatty acid synthesis (Fasn and Pnpla3), and fatty acid chain elongation (Elovl6) in the liver. However, HPHP inhibits the expression of triglyceride metabolites and promotes the expression of fatty acid transporter (CD36), fatty acid oxidation (Acacb), and peroxisome proliferator‐activated receptor gamma (PPARg) genes in the liver. Conclusion PHP regulates lipid metabolism through the gut microbiota, and the gut‐liver axis plays an important role in its hypolipidemic effects.

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Section: Discussionmentioning

confidence: 99%

Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut‐Liver Axis in Diet‐Induced High‐Fat Mesocricetus auratus through Multiple Integrated Omics

Zeng

Chen

Wang

et al. 2023

Molecular Nutrition Food Res

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“…TG was significantly increased in hypertensive patients compared to that of healthy patients [ 10 , 78 ] but decreased after treatment with anti-hypertensive medication [ 10 ]. Some DGs (DG 16:0/22:5 and DG 16:0/22:6) showed significantly higher levels in hypertensive patients plasma compared to that in normal patients [ 83 ]. LPC(22:6, 20:4, 18:1), PC(40:6), and SM(16:1, 24:2) were elevated in hypertensive patients compared to the levels in healthy patients, and they decreased after treatment with an herbal medicine (Ping Gan) with anti-hypertensive characteristics [ 10 , 11 ].…”

Section: Applications Of Lipidomics In Disease Researchmentioning

confidence: 99%

Mass Spectrometry-based Lipidomics and Its Application toBiomedical Research

Wu¹,

Shon²,

Liu³

2014

JLM

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Lipidomics, a branch of metabolomics, is the large-scale study of pathways and networks of all cellular lipids in biological systems such as cells, tissues or organisms. The recent advance in mass spectrometry technologies have enabled more comprehensive lipid profiling in the biological samples. In this review, we compared four representative lipid profiling technoligies including GC-MS, LC-MS, direct infusion-MS and imaging-MS. We also summarized representative lipid database, and further discussed the applications of lipidomics to the diagnostics of various diseases such as diabetes, obesity, hypertension, and Alzheimer diseases.

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Decoding the mechanism of hypertension through multiomics profiling

Adua

2022

J Hum Hypertens

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Hypertension, characterised by a constant high blood pressure, is the primary risk factor for multiple cardiovascular events and a major cause of death in adults. Excitingly, innovations in high-throughput technologies have enabled the global exploration of the whole genome (genomics), revealing dysregulated genes that are linked to hypertension. Moreover, post-genomic biomarkers, from the emerging fields of transcriptomics, proteomics, glycomics and lipidomics, have provided new insights into the molecular underpinnings of hypertension. In this paper, we review the pathophysiology of hypertension, and highlight the multi-omics approaches for hypertension prediction and diagnosis.

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Plasma Lipidomic Profile Signature of Hypertension in Mexican American Families

Cited by 3 publications

References 9 publications

Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut‐Liver Axis in Diet‐Induced High‐Fat Mesocricetus auratus through Multiple Integrated Omics

Porphyra haitanensis Polysaccharides Attenuates Blood Lipid via Gut‐Liver Axis in Diet‐Induced High‐Fat Mesocricetus auratus through Multiple Integrated Omics

Mass Spectrometry-based Lipidomics and Its Application toBiomedical Research

Decoding the mechanism of hypertension through multiomics profiling

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