Plasma Nanotextured Polymeric Surfaces for Controlling Cell Attachment and Proliferation: A Short Review

Tserepi, Angeliki; Gogolides, Εvangelos; Bourkoula, Athanasia; Kanioura, Anastasia; Kokkoris, George; Petrou, Panagiota; Kakabakos, Sotirios

doi:10.1007/s11090-015-9674-1

Cited by 45 publications

(35 citation statements)

References 53 publications

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“…X-ray Photoelectron Spectroscopy (XPS) measurements reveal that oxygen content on the surface is increased, carbon content is depleted while oxygen functional groups are formed such as carbonyl (-C=O), carboxyl (-COOH) and carbonate (CO 3 ) [21,[26][27][28]. The appearance of functional groups increases the surface free energy of the material.…”

Section: Resultsmentioning

confidence: 99%

“…[21] However, the rendered hydrophilicity by the oxygen plasma treatment is subject to aging effects causing hydrophobic recovery of the treated surface. Ageing effects can be attributed to a thermodynamically driven reorientation of the oxygen functional groups away from the surface into the sub-surface and the decay of these hydrophilic groups by atmospheric contaminants [28][29][30].…”

Section: Resultsmentioning

confidence: 99%

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Long-lasting FR-4 surface hydrophilisation towards commercial PCB passive microfluidics

Vasilakis

Moschou

Carta

et al. 2016

Applied Surface Science

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Highlights oxygen plasma treatment on FR-4 laminates  effect of power and exposure time studied to achieve long-lasting hydrophilic properties  super-hydrophilic surface for 13 days demonstrated  surface remains weakly hydrophilic between 13 th and 26 th day after the treatment  hydrophilic behaviour is retained for 26 days in total  oxygen plasma treatment was used on a commercially manufactured PCB microfluidic chip to enable passive filling of a microfluidic network AbstractPrinted circuit boards (PCB) technologies are an attractive system for simple sensing and microfluidic systems. Controlling the surface properties of PCB material is an important part of this technology and to date there has been no study on long-term hydrophilisation stability of these materials. In this work, the effect of different oxygen plasma input power and treatment duration times on the wetting properties of FR-4 surfaces was investigated by sessile droplet contact angle measurements. Super and weakly hydrophilic behaviour was achieved and the retention time of these properties was studied, with the hydrophilic nature being retained for at least 26 days. To demonstrate the applicability of this treatment method, a commercially manufactured microfluidic structure made from a multilayer PCB (3-layer FR-4 stack) was exposed to oxygen plasma at the optimum conditions. The structures could be filled with deionised (DI) water under capillary flow unlike the virgin devices.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Long-lasting FR-4 surface hydrophilisation towards commercial PCB passive microfluidics

Vasilakis

Moschou

Carta

et al. 2016

Applied Surface Science

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“…There are no studies published, as far as the authors know, where energetic ion-beams are used for nanoscale patterning and structuring of porous and non-porous Ti-based materials engineered to stimulate cell behavior. Several studies have reported the effects of nanopatterned polymeric surfaces with mesenchymal stem cells [28,29]. However, metallic substrates required the combination of different strategies (lithography and plasma treatments) to reproduce the designed patterned on top of the surface [25,30,31].…”

Section: Introductionmentioning

confidence: 99%

Directed Irradiation Synthesis as an Advanced Plasma Technology for Surface Modification to Activate Porous and “as-received” Titanium Surfaces

Civantos

Allain

Pavón

et al. 2019

Metals

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For the design of smart titanium implants, it is essential to balance the surface properties without any detrimental effect on the bulk properties of the material. Therefore, in this study, an irradiation-driven surface modification called directed irradiation synthesis (DIS) has been developed to nanopattern porous and “as-received” c.p. Ti surfaces with the aim of improving cellular viability. Nanofeatures were developed using singly-charged argon ions at 0.5 and 1.0 keV energies, incident angles from 0° to 75° degrees, and fluences up to 5.0 × 1017 cm−2. Irradiated surfaces were evaluated by scanning electron microscopy, atomic force microscopy and contact angle, observing an increased hydrophilicity (a contact angle reduction of 73.4% and 49.3%) and a higher roughness on both surfaces except for higher incident angles, which showed the smoothest surface. In-vitro studies demonstrated the biocompatibility of directed irradiation synthesis (DIS) reaching 84% and 87% cell viability levels at 1 and 7 days respectively, and a lower percentage of damaged DNA in tail compared to the control c.p. Ti. All these results confirm the potential of the DIS technique to modify complex surfaces at the nanoscale level promoting their biological performance.

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“…The second motive for this work is based on the potential of low pressure plasma etching to induce surface roughness at micro-and nanoscale on polymeric substrates [45][46][47][48] and stems from the importance of surface roughness in several applications, such as the cell adhesion and proliferation, [49][50][51] and the altering of the wetting properties [52,53] of the surfaces.…”

Section: Introductionmentioning

confidence: 99%

Multiscale Modeling of Low Pressure Plasma Etching Processes: Linking the Operating Parameters of the Plasma Reactor with Surface Roughness Evolution

Mouchtouris

Kokkoris

2016

Plasma Processes & Polymers

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Α multiscale modeling framework, linking the operating parameters of a low pressure plasma reactor with the surface roughness being formed on the etched substrate, is developed. It consists of a) a reactor scale model, which calculates densities, energies, and fields in the reactor, b) a Monte Carlo (MC) particle tracing model, which calculates the ion energy and angular distributions on the substrate, and c) a MC surface model, which calculates the evolution of the surface morphology during etching. The case study is etching of polymeric substrates with Ar plasma in the GEC reactor. Based on a generic surface model, the effects of the operating conditions (pressure, power) on the roughness are investigated. The potential for non‐uniform and anisotropic roughness along the wafer radial direction is demonstrated.

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Plasma Nanotextured Polymeric Surfaces for Controlling Cell Attachment and Proliferation: A Short Review

Cited by 45 publications

References 53 publications

Long-lasting FR-4 surface hydrophilisation towards commercial PCB passive microfluidics

Long-lasting FR-4 surface hydrophilisation towards commercial PCB passive microfluidics

Directed Irradiation Synthesis as an Advanced Plasma Technology for Surface Modification to Activate Porous and “as-received” Titanium Surfaces

Multiscale Modeling of Low Pressure Plasma Etching Processes: Linking the Operating Parameters of the Plasma Reactor with Surface Roughness Evolution

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