Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland

Côté, Sylvie; Ayotte, Pierre; Dodin, Sylvie; Blanchet, Carole; Mulvad, Gert; Petersen, Henning S; Gingras, Suzanne; Dewailly, Éric

doi:10.1186/1476-069x-5-33

Cited by 35 publications

(53 citation statements)

References 37 publications

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“…Exposure to PCB in human populations near the Baltic coast resulted in gender-specific changes in bone quality, as assessed by altered bone mineral density, with a greater effect in males (Hodgson et al 2008). Increased vertebral fractures and incidences of osteoporosis were found in fishermen and fishermen's wives exposed to persistent organic pollutants (POP) through dietary intake of fatty fish from the Baltic (Alveblom et al 2003), while three independent studies found no statistically-significant association between bone mineral density and organochlorine concentrations after adjustment for age and body mass index (Wallin et al 2005;Côté et al 2006;Rignell-Hydbom et al 2009). Furthermore, alterations in bone quality were demonstrated for wildlife from organohalogencontaminated environments (Fox et al 2008;Johnson et al 2009;Lind et al 2003;Murtomaa et al 2007;RodriguezNavarro et al 2006;Roos et al 2010;Sonne et al 2004).…”

Section: Perinatal Exposure To Environmental Contaminants Detected Inmentioning

confidence: 97%

Perinatal Exposure to Environmental Contaminants Detected in Canadian Arctic Human Populations Changes Bone Geometry and Biomechanical Properties in Rat Offspring

Elabbas

Finnilä

Herlin

et al. 2011

Journal of Toxicology and Environmental Health, Part A

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Arctic inhabitants consume large proportions of fish and marine mammals, and are therefore continuously exposed to levels of environmental toxicants, which may produce adverse health effects. Fetuses and newborns are the most vulnerable groups. The aim of this study was to evaluate changes in bone geometry, mineral density, and biomechanical properties during development following perinatal exposure to a mixture of environmental contaminants corresponding to maternal blood levels in Canadian Arctic human populations. Sprague-Dawley rat dams were dosed with a Northern Contaminant Mixture (NCM) from gestational day 1 to postnatal day (PND) 23. NCM contains 27 contaminants comprising polychlorinated biphenyls, organochlorine pesticides, and methylmercury. Femurs were collected on PND 35, 77 and 350, and diaphysis was analyzed by peripheral quantitative computed tomography and three-point bending test, while femoral neck was assessed in an axial loading experiment. Dose-response modeling was performed to establish the benchmark dose (BMD) for the analyzed bone parameters. Exposure to the high dose of NMC resulted in short and thin femur with reduced mechanical strength in offspring at PND35. BMD of femur length, cortical area, and stiffness were 3.2, 1.6, and 0.8 mg/kg bw/d, respectively. At PND77 femur was still thin, but at PND350 no treatment-related bone differences were detected. This study provides new insights on environmental contaminants present in the maternal blood of Canadian Arctic populations, showing that perinatal exposure induces bone alterations in the young offspring. These findings could be significant from a health risk assessment point of view.

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Section: Perinatal Exposure To Environmental Contaminants Detected Inmentioning

confidence: 97%

Perinatal Exposure to Environmental Contaminants Detected in Canadian Arctic Human Populations Changes Bone Geometry and Biomechanical Properties in Rat Offspring

Elabbas

Finnilä

Herlin

et al. 2011

Journal of Toxicology and Environmental Health, Part A

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“…In this particular cohort study, univariate analyses showed significant negative associations between serum 2,2′,4,4′,5,5′-hexachlorbiphenyl (PCB 153), which is the most abundant PCB congener in the human body, and BMD evaluated using dual energy x-ray absorptiometry [40]. In addition, Côté et al [2] reported that the plasma concentrations of PCB 153 in Inuit women were inversely correlated with their bone density as evaluated by quantitative ultrasound in univariate analyses; however, this correlation did not reach statistical significance in multivariate analyses. In addition, high concentrations of PCB 153 were reported to act as an antagonist of the human SXR [34].…”

Section: Discussionmentioning

confidence: 96%

Steroid and xenobiotic receptor-mediated effects of bisphenol A on human osteoblasts

et al. 2016

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“…La collecte des données a été décrite précédemment par Côté et al (2006). Les critères requis pour participer à l'étude étaient d'être une femme âgée entre 49 et 64 ans, née au Groenland.…”

Section: Projet Groenland 2000 -2002unclassified

“…Au total, 167 femmes ont été invitées à participer à l'étude et à se présenter à la clinique de soins de santé de première ligne de l'Hôpital Queen Ingrid. Huit d'entre elles ont refusé, six autres ont été exclues pour cause de maladies (VIH, maladies mentales, grippe); finalement, 153 Inuites ont participé à l'étude (Côté et al 2006). Les participantes ont répondu à un questionnaire adapté de celui de l'étude MEDOSMediterranean osteoporosis study questionnaire (Dequeker et al 1991), lequel a été administré en danois par un interviewer lors d'une rencontre face-à -face.…”

Section: Projet Groenland 2000 -2002unclassified

“…Dans le projet Groenland, la précision in vivo a été évaluée par des mesures répétées conduites sur 15 sujets : le coefficient moyen de variation (CV) était de 1,1 % pour SI (Côté et al 2006). Des mesures in vivo répétées sur une année, sur une femme de 42 ans, avec le même appareil, ont conduit à une valeur moyenne du CV de 1,3 % pour SI (Côté, S., communication personnelle).…”

Section: Mesures Osseusesunclassified

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Le statut en acide eicosapentaénoïque est associé à des valeurs plus élevées de l’indice calcanéen ultrasonorestiffnesschez les femmes autochtones : résultats d’une étude longitudinale et de deux études transversales

AyotteP.¹,

DewaillyÉ.²,

DodinS.³

2014

Appl. Physiol. Nutr. Metab.

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Several studies have reported that the status in omega-3 polyunsaturated fatty acid (PUFA) and the omega-3/omega-6 PUFA ratio are positively related to bone health. This study aimed at examining the relationship between the status of different PUFAs and bone strength expressed by the stiffness index (SI) among indigenous women in northern Canada and Greenland, whose diets are rich in PUFAs compared to those of non-Aboriginals. Our study includes 118 Inuit women from Nuuk (Greenland), 195 Inuit women from Nunavik (Canada), and 249 Cree women of from East James Bay (Canada). Projects in Nunavik and in the Cree communities had a cross-sectional design and the Greenland project, a longitudinal design. The content of some PUFAs phospholipids of erythrocyte membranes was measured after transmethylation by gas chromatography coupled with a flame ionization detector. Stiffness index was measured by ultrasound at the right calcaneus with a water-bath Achilles Lunar instrument (Greenland) or an Achilles Insight instrument (Nunavik, East James Bay). Relations between SI and various PUFAs were studied using multiple linear regression analyses. Eicosapentaenoic acid (EPA) was positively and significantly associated with SI (log), even after adjustment for several confounders and covariates in all three projects. A high EPA status, resulting mainly from the consumption of fatty fish or marine mammal fat, seems to have a positive effect on bone strength measured by ultrasonography among Aboriginal women from three different populations.

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Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland

Cited by 35 publications

References 37 publications

Perinatal Exposure to Environmental Contaminants Detected in Canadian Arctic Human Populations Changes Bone Geometry and Biomechanical Properties in Rat Offspring

Perinatal Exposure to Environmental Contaminants Detected in Canadian Arctic Human Populations Changes Bone Geometry and Biomechanical Properties in Rat Offspring

Steroid and xenobiotic receptor-mediated effects of bisphenol A on human osteoblasts

Le statut en acide eicosapentaénoïque est associé à des valeurs plus élevées de l’indice calcanéen ultrasonorestiffnesschez les femmes autochtones : résultats d’une étude longitudinale et de deux études transversales

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