Plasma peptidases as prognostic biomarkers in patients with first-episode psychosis

Fernández‐Atutxa, Ainhoa; Echevarrı́a, Enrique; Larrinaga, Gorka; Gil, Javier; Martínez‐Cengotitabengoa, Mónica; González‐Pinto, Ana; Irazusta, Jon; Seco, Jesús

doi:10.1016/j.psychres.2015.04.027

Cited by 7 publications

(2 citation statements)

References 31 publications

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“…Because PREP, like FAP, appears as a circulating form in plasma [14], it has been repeatedly investigated as putative biomarker for several neurological and inflammatory diseases [15][16][17][18][19][20][21][22][23]. Low levels of circulating PREP were associated with depression [15], multiple sclerosis [18] and liver cirrhosis [22].…”

Section: Introductionmentioning

confidence: 99%

The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma

Bracke

Elzen

Veken

et al. 2019

Clinica Chimica Acta

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Section: Introductionmentioning

confidence: 99%

The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma

Bracke

Elzen

Veken

et al. 2019

Clinica Chimica Acta

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“…In a study evaluating patients with first-episode psychosis, basal DPP IV levels were found to be higher than healthy controls, and it was observed that they reached the highest level in the first month. A negative correlation was found between DPP IV levels and depressive symptoms in the first month (Fernández-Atucha et al, 2015). In a study, serum DPP IV, ADA activities in adult panic disorder patients were examined and it was found to be higher than healthy controls (Yolaç Yarpuz et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

The Activity of Adenosine Deaminase and Dipeptidyl Peptidase IV in Children With Attention Deficit Hyperactivity Disorder

Naralan,

Doğan,

Elgün

et al. 2023

J Atten Disord

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Objective: In this study, to investigate the place of T cell-mediated immunity in the etiology of ADHD, for which we do not have enough information; we aimed to investigate the activity of DPP IV and ADA, which are T cell-related enzymes, and the relationship of these enzymes with ADHD symptoms in children with ADHD. Methods: Twenty-seven children aged 6 to 12 years with a diagnosis of attention deficit hyperactivity disorder and 27 children aged 6 to 12 years without any psychiatric disease were included in the study. Results: While serum ADA and DPP-IV activity were found to be statistically significantly higher in the group with ADHD. There was no statistically significant correlation between serum ADA and DPP-IV activities and CTRS-R-L and CPRS-R-L in both groups. Conclusion: We think that T cell mediated inflammation may play a role in the etiology of ADHD due to changes in ADA and DPP-IV levels in children.

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Insulin-regulated aminopeptidase immunoreactivity is abundantly present in human hypothalamus and posterior pituitary gland, with reduced expression in paraventricular and suprachiasmatic neurons in chronic schizophrenia

Bernstein

Müller

Dobrowolny

et al. 2016

Eur Arch Psychiatry Clin Neurosci

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The vasopressin- and oxytocin-degrading enzyme insulin-regulated aminopeptidase (IRAP) is expressed in various organs including the brain. However, knowledge about its presence in human hypothalamus is fragmentary. Functionally, for a number of reasons (genetic linkage, hydrolysis of oxytocin and vasopressin, its role as angiotensin IV receptor in learning and memory and others) IRAP might play a role in schizophrenia. We studied the regional and cellular localization of IRAP in normal human brain with special emphasis on the hypothalamus and determined numerical densities of IRAP-expressing cells in the paraventricular, supraoptic and suprachiasmatic nuclei in schizophrenia patients and controls. By using immunohistochemistry and Western blot analysis, IRAP was immunolocalized in postmortem human brains. Cell countings were performed to estimate numbers and numerical densities of IRAP immunoreactive hypothalamic neurons in schizophrenia patients and control cases. Shape, size and regional distribution of IRAP-expressing cells, as well the lack of co-localization with the glia marker glutamine synthetase, show that IRAP is expressed in neurons. IRAP immunoreactive cells were observed in the hippocampal formation, cerebral cortex, thalamus, amygdala and, abundantly, hypothalamus. Double labeling experiments (IRAP and oxytocin/neurophysin 1, IRAP with vasopressin/neurophysin 2) revealed that IRAP is present in oxytocinergic and in vasopressinergic neurons. In schizophrenia patients, the numerical density of IRAP-expressing neurons in the paraventricular and the suprachiasmatic nuclei is significantly reduced, which might be associated with the reduction in neurophysin-containing neurons in these nuclei in schizophrenia. The pathophysiological role of lowered hypothalamic IRAP expression in schizophrenia remains to be established.

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Plasma peptidases as prognostic biomarkers in patients with first-episode psychosis

Cited by 7 publications

References 31 publications

The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma

The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma

The Activity of Adenosine Deaminase and Dipeptidyl Peptidase IV in Children With Attention Deficit Hyperactivity Disorder

Insulin-regulated aminopeptidase immunoreactivity is abundantly present in human hypothalamus and posterior pituitary gland, with reduced expression in paraventricular and suprachiasmatic neurons in chronic schizophrenia

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