Plasma pharmacokinetics and faecal excretion of ivermectin (Eqvalan® paste) and doramectin (Dectomax®, 1%) following oral administration in donkeys

Gökbulut, Cengiz; Boyacıoğlu, Murat; Karademir, Umit

doi:10.1016/j.rvsc.2005.01.002

Cited by 26 publications

(17 citation statements)

References 16 publications

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“…The parent compound of IVM in plasma was analysed using validated high‐performance liquid chromatography (HPLC) with a liquid–liquid phase extraction procedures. Plasma concentrations were measured by minor modification of the methods of Scott and McKellar (1992) and Gokbulut et al. (2001, 2005).…”

Section: Mean (±Sd) Pharmacokinetic Parameters Of Ivermectin (Ivm) Fmentioning

confidence: 99%

“…The parent compound of IVM in plasma was analysed using validated high-performance liquid chromatography (HPLC) with a liquid-liquid phase extraction procedures. Plasma concentrations were measured by minor modification of the methods of Scott and McKellar (1992) and Gokbulut et al (2001Gokbulut et al ( , 2005. A mobile phase consisting of acetonitrile and methanol (66:34 v/v) was delivered (Agilent 1100 Series QuatPump, Waldron, Germany) at a flow rate of 1.3 mL/min.…”

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confidence: 99%

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Comparison of plasma pharmacokinetic profile of ivermectin following administration of subcutaneous injection (Baymec^®) and oral tablet (Efektin^®) in goats

Gökbulut

Karademir

Boyacıoğlu

2007

Vet Pharm & Therapeutics

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Section: Mean (±Sd) Pharmacokinetic Parameters Of Ivermectin (Ivm) Fmentioning

confidence: 99%

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confidence: 99%

Comparison of plasma pharmacokinetic profile of ivermectin following administration of subcutaneous injection (Baymec^®) and oral tablet (Efektin^®) in goats

Gökbulut

Karademir

Boyacıoğlu

2007

Vet Pharm & Therapeutics

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“…IVM pharmacokinetics is affected by route of administration, formulation of the drug, interspecies and interindividual variation (McKellar and Benchaoui 1996). There is little pharmacokinetic data about donkey available in the literature (Scott 1997;Gokbulut et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Ivermectin residues in milk of lactating donkey (Equus asinus): current regulation and challenges for the future

et al. 2011

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Ivermectin (IVM) is a macrocyclic disaccharide anthelmintic agent with broad-spectrum antiparasitic action.\ud It is used for controlling internal and external parasites in food-producing animals (bovine, swine and equine\ud species), including donkey. This drug is included in Council Regulation (EEC) 2377/9, annex I, with\ud Maximum Residue Limit (MRL) ranging from 15 to 100 μg kg−1 depending on the species. The\ud pharmacokinetic characteristics of IVM mainly depend on the animal species, formulation and route of\ud administration. Due to its high lipophilicity it accumulates in milk of food producing animals. Detailed IVM\ud pharmacokinetic studies were carried out for horse, pig, cattle, sheep, and goat, but there is lack of information\ud for asinine species. Consequently, the absence of “label milk withdrawal time” and MRLs in donkey’s milk\ud indicates that IVM should not be used in lactating animals. On the contrary, information about IVM residues\ud in milk would be of paramount importance in view of the fact that donkey’s milk is a suggested substitute\ud for infants suffering from hypersensitivity to cow’s, sheep’s and goat’s milk protein or from multiple\ud hypersensitivity. European legislation does not explicitly state that an MRL should be determined for every\ud target species; however it’s interpretation led to MRLs being adopted for each species and each foodstuff.\ud Although IVM is approved for use in all lactating animal species the possibility of an illegal use should be\ud considered. In this paper, the problems arising from IVM administration in lactating donkey are analysed. A\ud particular attention is paid for the existing legislation and some proposals are suggested for regulatory\ud framework formulation

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“…The pharmacokinetic dispositions of endectocides are particularly influenced by several factors related with drug (physicochemical properties, formulation, and routes of administration) and animals (species, breed, gender, diet and body composition and condition) (McKellar & Gokbulut, 2012). Although, many studies have been carried out to determine the pharmacokinetic behavior of endectocides in horses (Marriner et al, 1987;Gokbulut et al, 2001Gokbulut et al, , 2010Pérez et al, 2003Pérez et al, , 2010; there are very few data in the literature on the plasma disposition of endectocides in donkeys (Scott, 1997;Gokbulut et al, 2005Gokbulut et al, , 2011. No information is available on milk excretion in donkeys.…”

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Plasma disposition and milk excretion of eprinomectin following pour‐on administration in lactating donkeys

Gökbulut

Naturali²,

Rufrano³

et al. 2012

Vet Pharm & Therapeutics

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Plasma pharmacokinetics and faecal excretion of ivermectin (Eqvalan® paste) and doramectin (Dectomax®, 1%) following oral administration in donkeys

Cited by 26 publications

References 16 publications

Comparison of plasma pharmacokinetic profile of ivermectin following administration of subcutaneous injection (Baymec^®) and oral tablet (Efektin^®) in goats

Comparison of plasma pharmacokinetic profile of ivermectin following administration of subcutaneous injection (Baymec^®) and oral tablet (Efektin^®) in goats

Ivermectin residues in milk of lactating donkey (Equus asinus): current regulation and challenges for the future

Plasma disposition and milk excretion of eprinomectin following pour‐on administration in lactating donkeys

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Plasma pharmacokinetics and faecal excretion of ivermectin (Eqvalan® paste) and doramectin (Dectomax®, 1%) following oral administration in donkeys

Cited by 26 publications

References 16 publications

Comparison of plasma pharmacokinetic profile of ivermectin following administration of subcutaneous injection (Baymec®) and oral tablet (Efektin®) in goats

Comparison of plasma pharmacokinetic profile of ivermectin following administration of subcutaneous injection (Baymec®) and oral tablet (Efektin®) in goats

Ivermectin residues in milk of lactating donkey (Equus asinus): current regulation and challenges for the future

Plasma disposition and milk excretion of eprinomectin following pour‐on administration in lactating donkeys

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Comparison of plasma pharmacokinetic profile of ivermectin following administration of subcutaneous injection (Baymec^®) and oral tablet (Efektin^®) in goats

Comparison of plasma pharmacokinetic profile of ivermectin following administration of subcutaneous injection (Baymec^®) and oral tablet (Efektin^®) in goats