Plasma Protein Thiols and Total Antioxidant Power in Pediatric Nephrotic Syndrome

Kadirvel, Karthikeyan; Sinha, Indrajit; Prabhu, Krishnananda; Bhaskaranand, Nalini; Rao, Anjali

doi:10.1159/000148210

Cited by 12 publications

(17 citation statements)

References 28 publications

(21 reference statements)

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“…In contrast, Karthikeyan et al [24] reported an increase in antioxidant status in children with NS. The native and total thiol and disulphide levels were significantly lower in the present study's NS patients.…”

Section: Discussionmentioning

confidence: 84%

“…Determination of the percentages of total thiols composed of native thiols is based on the native thiol/ total thiol ratio. Most of the literature on thiol and disulphide concerns low-molecular-weight thiol compounds and plasma total thiol [23,24].…”

Section: Introductionmentioning

confidence: 99%

“…In 2014, Erel and Neselioglu [22] developed a fully automated method for easily measuring DTDH with repeatability. The literature includes only a few studies on the association between NS and thiol [24,25] and to date, no study has examined DTDH in pediatric NS patients. As such, the present study aimed to determine if DTDH could be used as a biomarker of oxidative stress and antioxidant status in pediatric NS patients using Erel and Neselioglu [22] novel fully automated measurement method.…”

Section: Introductionmentioning

confidence: 99%

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Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome

Yazılıtaş

Öztek-Celebi

Erel

et al. 2019

Nephron

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Background: There is a growing body of evidence showing that there is an association between oxidative damage and kidney injury in patients with nephrotic syndrome (NS). Dynamic thiol/disulphide homeostasis (DTDH) is an important antioxidant system. The aim of this study was to determine if DTDH could be used as a biomarker of antioxidant status in pediatric NS patients using a novel automated method. Methods: The study included 39 patients with NS and 40 healthy controls. The DTDH level was measured using a calorimetric and automated method developed by Erel and Neselioglu. In the NS group, DTDH was measured during first-attack episode, relapse, and remission. Results: The native thiol, total thiol, and disulphide levels were significantly lower, the native thiol/total thiol ratio was significantly lower, and the disulphide/native thiol and disulphide/total thiol ratios were significantly higher in the NS patients during relapse and first-attack episode than during remission and in the controls. In addition, the native thiol and total thiol levels, and the native thiol/total thiol ratio were significantly lower, and the disulphide/native thiol and disulphide/total thiol ratios were significantly higher in the NS group during remission than those in the control group. Conclusions: The present findings show that DTDH shifted toward disulphide formation in the NS patients, even during remission. A clearer understanding of the mechanism of this disruption to homeostasis in NS patients might lead to the development of novel therapeutic strategies.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome

Yazılıtaş

Öztek-Celebi

Erel

et al. 2019

Nephron

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“…Of these, the majority were excluded after the first screening in terms of abstracts or titles, mainly because they were not relevant to INS. After full-text review of 14 articles, six [18][19][20][21][22][23] studies were excluded because they did not display the status of MDA, vitamin C or E. Finally, eight studies were included.…”

Section: Literature Searchmentioning

confidence: 99%

Serum levels of malondialdehyde, vitamin C and E in idiopathic nephrotic syndrome: a meta-analysis

Mao¹,

Zhang²,

Huang³

2014

Renal Failure

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It is well documented that oxidative stress is involved in the pathogenesis of idiopathic nephrotic syndrome (INS). Malondialdehyde (MDA) is a measurement of lipid oxidation; vitamin C and E are important components of antioxidants. However, the association between MDA, vitamin C or E levels and INS remains elusive. A meta-analysis was performed to investigate the alteration of serum levels of MDA, vitamin C and E in INS compared with controls. Eight studies were included in our meta-analysis according to predefined criteria. Active INS patients demonstrated significantly higher level of serum MDA (SMD: 2.13, 95% CI: 1.511 to 2.749, p510 ) and similar level of serum vitamin E compared with those in controls. No significant publication bias was observed. In conclusion, the disorder of MDA and vitamin C persists in the remission stage of INS. It seems that the serum levels of vitamin C and E is associated with the responsiveness of INS to steroids. However, more studies should be performed in the future.

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“…Levels of protein thiols and protein carbonyls in serum of brain tumor patients have been studied as an indicator of protein damage due to oxidative stress and significant alterations in their levels have been observed [22]. Many studies have observed altered protein thiols including alterations in the glutathione levels in various disease conditions with oxidative stress [23,24]. In this study, the salivary protein thiols were significantly decreased in the oral cancer patients when compared to healthy controls.…”

Section: Discussionmentioning

confidence: 55%

Protein Thiols and Butryrylcholinestrase in Saliva of Oral Cancer Patients

et al. 2013

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Oral squamous cell carcinoma is one of the most common malignancies recognized. Biomarkers which can predict presence of cancer and its progression can help in better management of these disorders. Over production of lipid peroxidation byproducts and disturbances in antioxidant defense system have been implicated in the pathogenesis of several diseases including oral cancer. Studies have shown a correlation of butyrylcholinesterase (BChE), with tumourigenesis, cell proliferation and cell differentiation. Earlier we have observed a significant elevation in plasma BChE and protein thiols in oral cancer patients which correlated well with stages of cancer. As it was not clear whether the above markers will be altered in saliva of oral cancer patients this study was undertaken. Institutional Ethics Committee gave permission to carry out this study. Total of 55 subjects comprising healthy controls (n = 30) and biopsy proven oral cancer patients (n = 25) consented to participate in this study. Salivary samples from cases were taken before any definitive treatment. Protein thiols and BChE were estimated in salivary samples using validated assay methods. Oral cancer patients had a significant increase in pre-treatment salivary BChE levels (p B 0.001) and a significant decrease (p B 0.001) in salivary thiols as compared to respective values in controls. Salivary protein thiols and BChE may have a role in pathophysiology of oral cancer. Saliva can be used as a potential non-invasive screening tool in oral cancer patients.

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Plasma Protein Thiols and Total Antioxidant Power in Pediatric Nephrotic Syndrome

Cited by 12 publications

References 28 publications

Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome

Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome

Serum levels of malondialdehyde, vitamin C and E in idiopathic nephrotic syndrome: a meta-analysis

Protein Thiols and Butryrylcholinestrase in Saliva of Oral Cancer Patients

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