Plasma-treated silk fibroin nanofibers for skin regeneration

Jeong, Lim; Yeo, In‐Sung; Kim, Hana; Yoon, Young Il; Jang, Da Hyun; Jung, Sung Youn; Min, Byung‐Moo; Park, Won Ho

doi:10.1016/j.ijbiomac.2008.12.008

Cited by 96 publications

(57 citation statements)

References 26 publications

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“…Hemicelluloses are polysaccharides that occur together with cellulose in most plant tissues. The predominant hemicellulose present in hardwoods such as birch and aspen is an O-(4-Omethylglucurono) Xylan [9][10][11] and these are abundant in naturally occurring polysaccharides representing a large and cost-effective source of polymeric materials in tissue engineering applications [12]. In the present study, we have evaluated the efficacy of these biodegradable Xylan/PVA nanofiber matrices as dermal substitutes by seeding fibroblasts for skin tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide nanofibrous scaffolds as a model for in vitro skin tissue regeneration

Krishnan

Rajeswari

Venugopal

et al. 2012

J Mater Sci: Mater Med

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Tissue engineering and nanotechnology have advanced a general strategy combining the cellular elements of living tissue with sophisticated functional biocomposites to produce living structures of sufficient size and function at a low cost for clinical relevance. Xylan, a natural polysaccharide was electrospun along with polyvinyl alcohol (PVA) to produce Xylan/PVA nanofibers for skin tissue engineering. The Xylan/PVA glutaraldehyde (Glu) vapor cross-linked nanofibers were characterized by SEM, FT-IR, tensile testing and water contact angle measurements to analyze the morphology, functional groups, mechanical properties and wettability of the fibers for skin tissue regeneration. The cell-biomaterial interactions were studied by culturing human foreskin fibroblasts on Xylan/PVA Glu vapor cross-linked and Xylan/PVA/Glu blend nanofibrous scaffolds. The observed results showed that the mechanical properties (72 %) and fibroblast proliferation significantly increased up to 23 % (P < 0.05) in 48 h Glu vapor cross-linked nanofibers compared to 24 h Glu vapor cross-linked Xylan/PVA nanofibers. The present study may prove that the natural biodegradable Xylan/PVA nanofibrous scaffolds have good potential for fibroblast adhesion, proliferation and cell matrix interactions relevant for skin tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Polysaccharide nanofibrous scaffolds as a model for in vitro skin tissue regeneration

Krishnan

Rajeswari

Venugopal

et al. 2012

J Mater Sci: Mater Med

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“…For applications in biomedical area, electrospun membranes with biocompatibility and biodegradability were investigated, including both synthetic polymers, e.g., poly(lactic acid) (PLA) [4,5], poly(-caprolactone) (PCL) [6][7][8], and the copolymers poly(lactic-co-glycolic acid) (PLGA) [9][10][11], poly(L-lactic acid-co--caprolactone) (PLCL) [12,13], and natural ones such as chitosan [14,15], collagen [16,17], gelatin [18], and silk [19,20], as well as compounds of them [21]. The fibrous membranes could be used as scaffolds in tissue engineering of the skin [11,22], blood vessel [23], ligament [24], nerve [5,12,25,26], cartilage [27] as well as the bone [6,8,28]. Additionally, the structure of core/shell fibers prepared by coaxial or emulsion electrospinning could provide a more effective method to encapsulate bioactive additives in the polymeric fibers [29,30].…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of ultrafine core/shell fibers for biomedical applications

Zhang

Zhao

et al. 2010

Sci. China Chem.

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Because of the inherent appearance similar to the natural extracellular matrix, ultrafine fibrous membranes prepared via electrospinning exhibit widespread applications, especially in the biomedical area. Extensional modifications of coaxial and emulsion electrospinning have drawn much attention in preparation of core/shell fibers for applications as tissue engineering scaffolds and controlled delivery systems for bioactive substances. Due to incorporation of multi-components in the electrospun core/ shell fibers, the process of coaxial and emulsion electrospinning became more susceptible. The theories have not been fully understood. A series of investigations were carried out evaluating the systematic and processing parameters. This paper reviews advantages and potentials of electrospun core/shell fibers as well as factors influencing their formation on the basis of our research and new progress. core/shell fibers, coaxial electrospinning, emulsion electrospinning, controlled delivery, tissue engineering

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“…The application of nanofibres in research aiming to obtain new materials for medicine has been reflected in numerous publications [27,29,30]. The relevant literature includes many papers devoted to the use of nanofibres in the treatment of osseous tissue [31,32], articular cartilages [33,34], muscles [35], ligaments [36], skin [12,37] and use in cardiosurgery [9].…”

Section: Methods Of Obtaining and Characterising The Spinning Solutionmentioning

confidence: 99%

Fabrication of Plga/Hap and Plga/Phb/Hap Fibrous Nanocomposite Materials for Osseous Tissue Regeneration

Krucińska

Chrzanowska

Boguń

et al. 2014

Autex Research Journal

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The study presents the manufacturing of nanofibrous structures as osteoconductive, osteoinductive materials for osseous tissue regeneration. The fibrous structures were obtained by electrospinning of poly(l-lactide-coglicolide) (PLGA) with addition of hydroxyapatite (HAp) and of a blend of PLGA with polyhydroxybutyrate with HAp added. The polymers used in the experiment were synthesised by an innovative method with a zirconium catalyst. First, the optimal electrospinning process parameters were selected. For the characterisation of the obtained osseous tissue reconstruction materials, the physical, macroscopic, functional, mechanical and thermal properties as well as crystallinity index were studied. The study of the radiation sterilisation influence on average molar mass, thermal and mechanical properties was made in order to analyse the degradation effect.

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Plasma-treated silk fibroin nanofibers for skin regeneration

Cited by 96 publications

References 26 publications

Polysaccharide nanofibrous scaffolds as a model for in vitro skin tissue regeneration

Polysaccharide nanofibrous scaffolds as a model for in vitro skin tissue regeneration

Electrospinning of ultrafine core/shell fibers for biomedical applications

Fabrication of Plga/Hap and Plga/Phb/Hap Fibrous Nanocomposite Materials for Osseous Tissue Regeneration

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