Plasma tumor necrosis factor-α and C-reactive protein as biomarker for survival in head and neck squamous cell carcinoma

Andersson, Bengt-Åke; Lewin, Freddi; Lundgren, Jan; Nilsson, Mats; Rutqvist, Lars‐Erik; Löfgren, Sture; Laytragoon‐Lewin, Nongnit

doi:10.1007/s00432-014-1592-8

Cited by 48 publications

(47 citation statements)

References 18 publications

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“…As a consequence of the inflammation microenvironment and massive cell death induced by HPV or smoking, chronic inflammation occurs [14,26,28,29] . Increasing inflammation-related proteins, CRP and cytokines, and TNFα in the plasma of H&N cancer patients supported our assumption [12] .…”

Section: Discussionsupporting

confidence: 73%

“…In accordance with previous investigations, a high proportion of H&N cancer patients were middle-aged males [12,13,15] . This might be due to the fact that historically, males have smoked more than females [24] .…”

Section: Discussionsupporting

confidence: 65%

“…To test this hypothesis, 45 candidate SNPs in 41 genes were analyzed for their association to cancer risk, tumour recurrence, and survival time in H&N cancer patients. These genes were selected based on their documented function in DNA repair, cell cycle progression, cell death, and immune response [8,12,14,18,19] .…”

Section: Discussionmentioning

confidence: 99%

“…Chronic inflammation as a result of smoking or HPV infection might influence the levels of inflammatory cytokines and proteins in the plasma of H&N cancer patients [12] . Host immune response could also affect clinical outcome since an inverse relationship has been described between circulating lymphocytes expressing cytolyses granules, perforin, and survival among H&N cancer patients [13] .…”

Section: Introductionmentioning

confidence: 99%

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Single-Nucleotide Polymorphisms and Cancer Risk, Tumor Recurrence, or Survival of Head and Neck Cancer Patients

Laytragoon‐Lewin

Cederblad²,

Andersson³

et al. 2016

Oncology

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Objective: This paper aims at studying the influence of single-nucleotide polymorphisms (SNPs) on cancer risk, tumor recurrence, and survival in head and neck (H&N) cancer patients. Methods: A total of 45 SNPs in 41 genes were investigated. A total of 174 Caucasian H&N cancer patients and 245 healthy blood donors were enrolled in the study. Results: Ten SNPs were associated with H&N cancer risk, but the identified SNPs differed among males and females. Some of the SNPs were related to immune response genes. The immune response gene SNPs were also related to survival. In particular, we noted that the tumor necrosis factor alpha (TNFα) rs1800629 could have an influence on cancer risk, tumor recurrence as well as survival. Conclusion: Genetic variation of the TNFα rs1800629 might be useful as a biomarker in clinical decision-making since it was found to be related to cancer risk, tumor recurrence, and survival of H&N cancer patients.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Single-Nucleotide Polymorphisms and Cancer Risk, Tumor Recurrence, or Survival of Head and Neck Cancer Patients

Laytragoon‐Lewin

Cederblad²,

Andersson³

et al. 2016

Oncology

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“…This hypothalamic resistance to peripheral neuroendocrine starvation signals is believed to be directly caused by an increased inflammatory status [5]. Increased plasma levels of proinflammatory cytokines are associated with disease progression in a variety of cachectic conditions including cancer [6][7][8], HIV [9], heart failure [10,11] and COPD [12].…”

Section: Introductionmentioning

confidence: 99%

Hypothalamic inflammation and food intake regulation during chronic illness

et al. 2016

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Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy

Hsieh

Wang

et al. 2019

Head & Neck

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Background Biomarkers in head and neck squamous cell carcinoma (HNSCC) emerge rapidly in recent years, especially for new targeted therapies and immunotherapies. Methods Recent, relevant peer‐reviewed evidence were critically reviewed and summarized. Results This review article briefly introduces essential biomarker concepts, including purposes and classifications (predictive, prognostic, and diagnostic markers), and the phases of biomarker development. We summarize current biomarkers in order of clinical utility; p16 and human papillomavirus status remain the most important and validated biomarkers in HNSCC. The rationale for biomarker study design continues to evolve with technological advances, especially whole‐exome or whole‐genomic sequencing. Noninvasive body fluid and liquid biopsy biomarkers appear to hold strong potential for development as tools for early cancer detection, cancer diagnosis, monitoring of disease recurrence, and outcome prediction. In light of discrepancies among different technologies, standardized approaches are needed. Conclusion Biomarkers from cancer tissue or blood in HNSCC could direct new anticancer therapies.

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Plasma tumor necrosis factor-α and C-reactive protein as biomarker for survival in head and neck squamous cell carcinoma

Abstract: Our findings indicate that CRP and TNF-α might be suitable as biomarkers in combination with tumor TNM staging for predicting survival and individualized treatment of HNSCC patients. Plasma CRP and TNF-α analysis are simple, rapid, cost effective and suitable for clinical practice.

Cited by 48 publications

References 18 publications

Single-Nucleotide Polymorphisms and Cancer Risk, Tumor Recurrence, or Survival of Head and Neck Cancer Patients

Single-Nucleotide Polymorphisms and Cancer Risk, Tumor Recurrence, or Survival of Head and Neck Cancer Patients

Hypothalamic inflammation and food intake regulation during chronic illness

Review of emerging biomarkers in head and neck squamous cell carcinoma in the era of immunotherapy and targeted therapy

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