Plasma versus Salivary Chromogranin A as Selective Markers in Pheochromocytoma Diagnosis

Stefanescu, Ana-Maria; Schipor, Sorina; Păun, Diana; Dumitrache, Constantin; Badiu, Corin; Davila, Carol; Endocrinology, General

doi:10.4183/aeb.2011.153

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…A measure of the faster physiological stress response system, the sympathetic adrenomedullarly system (SAM), is an acidic protein called chromogranin A (CgA). CgA is a novel stress marker, which is co-released with catecholamines (epinephrine and norepinephrine) from the adrenal medulla and sympathetic axons (van Kammen et al, 1992; Kanno et al, 1999; Stefanescu et al, 2011). CgA is an excellent tool for measuring SAM activity because it is more stable than catecholamines in the circulatory system, as it lasts longer and is consequently easier to measure, especially in saliva (Kanno et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…CgA is an excellent tool for measuring SAM activity because it is more stable than catecholamines in the circulatory system, as it lasts longer and is consequently easier to measure, especially in saliva (Kanno et al, 1999). Like CORT, CgA concentrations in the saliva have been measured in both dogs (Akiyoshi et al, 2005; Kanai et al, 2008) and humans, and salivary and plasma levels are highly correlated (Nakane et al, 1998, 2002; Den et al, 2011; Stefanescu et al, 2011). Using CORT and CgA should allow a more precise determination of both slower and faster physiological changes, respectively (or, potentially, levels of perceived stress severity).…”

Section: Introductionmentioning

confidence: 99%

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Physiological Indicators of Attachment in Domestic Dogs (Canis familiaris) and Their Owners in the Strange Situation Test

Ryan

Storey

Anderson

et al. 2019

Front. Behav. Neurosci.

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Behaviorally, attachment is demonstrated when one individual maintains close proximity to another individual and shows distress upon separation. For 29 owner-dog dyads, we employed a modified Ainsworth’s Strange Situation Test (SST) to investigate whether both members would show a physiological reaction to separation. Dogs experienced a series of separation from and reuniting events with their owners and were introduced to a stranger. Before and after the SST, saliva samples were taken from each dyad to measure stress-related analytes: cortisol (CORT) and chromogranin A (CgA). Dogs exhibited attachment behaviors toward owners as evidenced by more time spent in close proximity, more contact initiated and less time spent near the door, compared to episodes with the stranger. Dogs that initiated more contact with their owners in re-uniting episodes had lower CgA than dogs that initiated less contact, but their owners had higher CgA levels. Also during re-uniting episodes, dogs and owners spent more time near each other when owner CgA levels were low, owner CORT levels were high, and the dog had owner-reported separation anxiety. During the episodes alone with the stranger, dogs with higher CORT spent more time with the stranger. Finally, dogs’ initial CgA levels were correlated with their owner’s initial CORT levels, and dog final CORT levels were correlated with their owners’ final CORT levels, suggesting some hormonal synchrony within the dyad. As all owner-dog dyads were assessed as securely attached, attachment style differences could not explain variation in hormonal or behavioral results. These results suggest that dogs may respond to owner hormonal state and/or behavior and demonstrate that individual differences in responses to a behavioral challenge reflect the stress physiology of both dogs and their owners.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physiological Indicators of Attachment in Domestic Dogs (Canis familiaris) and Their Owners in the Strange Situation Test

Ryan

Storey

Anderson

et al. 2019

Front. Behav. Neurosci.

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“…catecholamines)(9) can be assessed in saliva, serum or urine. The applicability of saliva CgA seems to be similar to plasma samples (10), urine values are less accurate (11).…”

Section: Introductionmentioning

confidence: 99%

The Assessment of the Autonomic Response to Acute Stress Using Electrodermal Activity

Mestanlk

Vlsnovcova

Tonhajzerová

2014

Acta Medica Martiniana

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A b s t r a c tThe response of autonomic nervous system to mental stress is currently studied as a key role factor in the pathophysiology of stress related diseases. Altered autonomic regulation can result in increased morbidity, potentially affecting (directly or indirectly) any of the organs. Cardiovascular system (CVS) is one of the most sensitive systems to the effect of autonomic outputs. The predictive value of the laboratory stress tests was proved in several studies with CVS pathology. In this study we aimed to assess the autonomic reactivity to different mental stressors (cognitive and emotional) in healthy subjects using electrodermal activity (EDA) as a sensitive psychophysiological marker of sympathetic activity. We found significantly increased EDA in response to all the mental tasks with decrease of the values during recovery periods. However, EDA did not return to the baseline values during recovery periods, potentially indicating the sympathetic arousal during complete stress profile protocol. We suggest EDA presents a well applicable marker of the sympathetic activation, offering a different information about central regulation processes regarding the sympathetic activity compared to cardiac autonomic indices.

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Biological function and clinical relevance of chromogranin A and derived peptides

D’Amico¹,

Ghinassi²,

Izzicupo³

et al. 2014

Endocrine Connections

105

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Chromogranin A (CgA (CHGA)) is the major soluble protein co-stored and co-released with catecholamines and can function as a pro-hormone by giving rise to several bioactive peptides. This review summarizes the physiological functions, the pathogenic implications, and the recent use of these molecules as biomarkers in several pathological conditions. A thorough literature review of the electronic healthcare databases MEDLINE, from January 1985 to September 2013, was conducted to identify articles and studies concerned with CgA and its processing. The search strategies utilized keywords such as chromogranin A, vasostatins 1 and 2, chromofungin, chromacin, pancreastatin, catestatin, WE14, chromostatin, GE25, parastatin, and serpinin and was supplemented by the screening of references from included papers and review articles. A total of 209 English-language, peer-reviewed original articles or reviews were examined. The analysis of the retrospective literature suggested that CgA and its several bioactive fragments exert a broad spectrum of regulatory activities by influencing the endocrine, the cardiovascular, and the immune systems and by affecting the glucose or calcium homeostasis. As some peptides exert similar effects, but others elicit opposite responses, the regulation of the CgA processing is critical to maintain homeostasis, whereas an unbalanced production of peptides that exert opposing effects can have a pathogenic role in several diseases. These clinical implications entail that CgA and its derived peptides are now used as diagnostic and prognostic markers or to monitor the response to pharmacological intervention not only in endocrine tumors, but also in cardiovascular, inflammatory, and neuropsychiatric diseases.

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Plasma versus Salivary Chromogranin A as Selective Markers in Pheochromocytoma Diagnosis

Cited by 3 publications

References 16 publications

Physiological Indicators of Attachment in Domestic Dogs (Canis familiaris) and Their Owners in the Strange Situation Test

Physiological Indicators of Attachment in Domestic Dogs (Canis familiaris) and Their Owners in the Strange Situation Test

The Assessment of the Autonomic Response to Acute Stress Using Electrodermal Activity

Biological function and clinical relevance of chromogranin A and derived peptides

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