Plasmonic gold nanostructures for biosensing and bioimaging

Abstract

Graphical abstract As one kind of noble metal nanostructures, the plasmonic gold nanostructures possess unique optical properties as well as good biocompatibility, satisfactory stability, and multiplex functionality. These distinctive advantages make the plasmonic gold nanostructures an ideal medium in developing methods for biosensing and bioimaging. In this review, the optical properties of the plasmonic gold nanostructures were firstly introduced, and then biosensing in vitro based on localized surface plasmon resonance, Rayleigh scattering, surface-enhanced fluorescence, and Raman scattering were summarized. Subsequently, application of the plasmonic gold nanostructures for in vivo bioimaging based on scattering, photothermal, and photoacoustic techniques has been also briefly covered. At last, conclusions of the selected examples are presented and an outlook of this research topic is given.

Design Strategy for Nanostructured Arrays of Metallodielectric Cuboids to Systematically Tune the Optical Response and Eliminate Spurious Bulk Effects in Plasmonic Biosensors

“…To reduce the effort and costs for the production of the devices, replication from a master structure [ 41 ] will probably be the most effective approach, e.g., by molding procedures [ 42 ]. The option of signal control [ 4 , 38 , 43 , 44 ] and biofunctionalization make plasmonic platforms a powerful tool in the field of clinical studies [ 43 , 45 ].…”

PVP‐Capped Gold Nanoparticles: Thermal Nonlinear Refraction Probed by Spatial Self‐Phase Modulation

“…[10][11][12][13] SSPM has also been employed for studying the nonlinear optical properties of thermal origin of 2D nanostructured materials, for instance Bi 2 Se 3 -Bi 2 Te 3 heterostructures, [14] iron phosphorus trichalcogenides, [15] graphene oxide, [16] antimonene, [17] ultrathin niobium carbide sheets, [18] germanium selenide nanoflakes, [19] and fullerenes [20] and NbSe 2 [21] besides perovskite quantum dots [22] and silver nanocrystals of divers geometry. [23] Due to the high biocompatibility and optical properties, gold nanoparticles (AuNPs) of different shapes have been tested for numerous applications as theranostics, [24] biosensing and imaging, [25] cancer therapy, [26] and drug delivery. [27] For applications involving clinical trials in human beings and animals models, important issues are the stability and biocompatibility of the nanoparticles.…”

“…Due to the high biocompatibility and optical properties, gold nanoparticles (AuNPs) of different shapes have been tested for numerous applications as theranostics, [ 24 ] biosensing and imaging, [ 25 ] cancer therapy, [ 26 ] and drug delivery. [ 27 ] For applications involving clinical trials in human beings and animals models, important issues are the stability and biocompatibility of the nanoparticles.…”

Optical Force and Torque on a Graphene-Coated Gold Nanosphere by a Vector Bessel Beam

“…In recently years, gold nanoparticles have proven to be an excellent tool for optical-tweezer-based micromanipulation due to their properties of large polarizability, relatively low cytotoxicity, and localized surface plasmon resonance (LSPR) [ 42 , 43 , 44 ], and optically trapped gold nanoparticles have wide applications in bioengineering such as nanosensors [ 45 , 46 ], bioimaging [ 47 , 48 , 49 , 50 ], diagnostics [ 51 , 52 , 53 ], etc. For instance, gold nanoaperture optical tweezers have been used for the manipulation, sensing, and spectroscopy of biological nanoparticles below 50 nm in size [ 54 ].…”