Plasmonic nanoparticles and their characterization in physiological fluids

Urban, Dominic A.; Rodríguez‐Lorenzo, Laura; Balog, Sandor; Kinnear, Calum; Rothen‐Rutishauser, Barbara; Petri‐Fink, Alke

doi:10.1016/j.colsurfb.2015.05.053

Cited by 40 publications

(30 citation statements)

References 117 publications

(161 reference statements)

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“…Upon contact with physiological fluids, the formation of a surface‐bound protein layer, particle dissolution, or aggregation might occur, which are expected to have a crucial impact on cellular, tissue, and organ interaction . For the subsequent fate it is important to understand the consequences of the interactions of nanomaterials with physiological fluids including mucus (gastrointestinal (GI) or respiratory tract), aqueous lining layer covered by surfactant (lung parenchyma), the blood or the lymphatic fluid, as well as available analytical methods to investigate the possible interactions …”

Section: Therapeutic Nanomaterials—possible Routes Of Exposurementioning

confidence: 99%

Biodistribution, Clearance, and Long‐Term Fate of Clinically Relevant Nanomaterials

et al. 2018

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Realization of the immense potential of nanomaterials for biomedical applications will require a thorough understanding of how they interact with cells, tissues, and organs. There is evidence that, depending on their physicochemical properties and subsequent interactions, nanomaterials are indeed taken up by cells. However, the subsequent release and/or intracellular degradation of the materials, transfer to other cells, and/or translocation across tissue barriers are still poorly understood. The involvement of these cellular clearance mechanisms strongly influences the long-term fate of used nanomaterials, especially if one also considers repeated exposure. Several nanomaterials, such as liposomes and iron oxide, gold, or silica nanoparticles, are already approved by the American Food and Drug Administration for clinical trials; however, there is still a huge gap of knowledge concerning their fate in the body. Herein, clinically relevant nanomaterials, their possible modes of exposure, as well as the biological barriers they must overcome to be effective are reviewed. Furthermore, the biodistribution and kinetics of nanomaterials and their modes of clearance are discussed, knowledge of the long-term fates of a selection of nanomaterials is summarized, and the critical points that must be considered for future research are addressed.

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Section: Therapeutic Nanomaterials—possible Routes Of Exposurementioning

confidence: 99%

Biodistribution, Clearance, and Long‐Term Fate of Clinically Relevant Nanomaterials

et al. 2018

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“…Cationic GNR with superior stability to PAH-GNR were prepared utilizing two moieties: 1) thiolated cationic ligand (cystamine hydrochloride) to provide effective positive surface charge and 2) thiolated PEG-SH to maintain colloidal stability of GNR via steric repulsion ( Figure 1D). 18,30 Upon surface functionalization to prepare PAA-GNR and PAH-GNR, no significant broadening or tailing of the longitudinal peaks of the optical spectra was observed, suggesting a maintained colloidal stability without aggregation. The observed small red shift in the longitudinal plasmon peak upon surface modification with (PAA, PAH, PEG-SH) is attributed to the change in the local refractive index around the GNR core upon surface functionalization (Figure 2A).…”

Section: Discussionmentioning

confidence: 99%

“…17,18 The colloidal stability of GNP in biological fluids is essential in most applications, such as drug delivery, imaging, and diagnosis. Bacterial growth media (for in vitro studies) are rich in peptides, amino acids, electrolytes, and other chemicals, which may induce aggregation of nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, the excellent stability of PEG-GNR and PEG-Cys-GNR suspensions upon mixing with bacterial growth media might be related to the presence of PEG shell that provides steric stabilization and prevents non-specific protein adsorption. 18,30 In addition, the excellent stability of the anionic PAA-GNR suspension might be due to the repulsion forces between the negatively charged nanoparticles and peptones in the growth media. Unfortunately, this crucial factor of media-induced aggregation is ignored in the literature and might contribute to the observed conflicting findings.…”

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confidence: 99%

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Antibacterial activity of gold nanorods against <em>Staphylococcus aureus</em> and<em> Propionibacterium acnes</em>: misinterpretations and artifacts

Mahmoud

Alkilany

Khalil

et al. 2017

IJN

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The antibacterial activity of gold nanorod (GNR) suspensions of different surface functionalities was investigated against standard strains of Staphylococcus aureus and Propionibacterium acnes , taking into consideration two commonly “overlooked” factors: the colloidal stability of GNR suspensions upon mixing with bacterial growth media and the possible contribution of “impurities/molecules” in GNR suspensions to the observed antibacterial activity. The results demonstrated that cationic polyallylamine hydrochloride (PAH)-GNR were severely aggregated when exposed to bacterial growth media compared to other GNR suspensions. In addition, the free cetyltrimethylammonium bromide (CTAB) present in GNR suspensions is most likely the origin of the observed antibacterial activity. However, the antibacterial activity of GNR themselves could not be excluded. Probing these two critical control studies prevents misinterpretations and artifacts of the antibacterial activity of nanoparticles. Unfortunately, these practices are usually ignored in the published studies and may explain the significant conflicting results. In addition, this study indicates that GNR could be a promising candidate for the treatment of skin follicular diseases such as acne vulgaris.

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“…19,20 Dynamic depolarized light scattering (DDLS) potentially offers clear advantages over competing techniques, especially when it comes to probing NPs in situ in complex biological and physiological fluids. 21 An inherent but often critical feature of scattering experiments using biological and physiological fluids is that the measured primary signal, that is, the scattering intensity, contains contributions from proteins. These contributions to the scattering intensity may be significant; however, separating the relevant signals from the irrelevant ones is not trivial, which hinders the effective usage of DLS for investigating NPs in these application-relevant environments.…”

Section: Introductionmentioning

confidence: 99%

A new angle on dynamic depolarized light scattering: number-averaged size distribution of nanoparticles in focus

et al. 2016

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Plasmonic nanoparticles and their characterization in physiological fluids

Cited by 40 publications

References 117 publications

Biodistribution, Clearance, and Long‐Term Fate of Clinically Relevant Nanomaterials

Biodistribution, Clearance, and Long‐Term Fate of Clinically Relevant Nanomaterials

Antibacterial activity of gold nanorods against <em>Staphylococcus aureus</em> and<em> Propionibacterium acnes</em>: misinterpretations and artifacts

A new angle on dynamic depolarized light scattering: number-averaged size distribution of nanoparticles in focus

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