Plasmonic nanosensors with inverse sensitivity by means of enzyme-guided crystal growth

Properties and Customization of Sensor Materials for Biomedical Applications

“…In fact, it has been shown that for the detection of CA15-3-antigen, a known breast cancer biomarker, the application of Au-NPs labeled with HRP and CA15-3-antibody enhanced the sensitivity and shortened the incubation time of a commercially available ELISA immunoassay from 30 to only 5 min (230). Stevens et al (231) developed a colorimetric prostate specific antigen (PSA) nanosensor, using gold nanostars. An antibody was tagged to GO x that in the presence of PSA caused the formation of the antibody-antigen-labeled antibody complex.…”

“…An antibody was tagged to GO x that in the presence of PSA caused the formation of the antibody-antigen-labeled antibody complex. In the presence of glucose and silver ions (both added to the solution), GO x converted glucose to gluconolactone and H 2 O 2 , which then reduced silver ions around the gold nanostars (231). When the concentration of GO x was low, i.e., proportionally to antigen concentration, a homogenous silver coating on the nanostars was observed causing a large blue-shift of the SPR of the nanostar (231).…”

“…In the presence of glucose and silver ions (both added to the solution), GO x converted glucose to gluconolactone and H 2 O 2 , which then reduced silver ions around the gold nanostars (231). When the concentration of GO x was low, i.e., proportionally to antigen concentration, a homogenous silver coating on the nanostars was observed causing a large blue-shift of the SPR of the nanostar (231). This resulted in an exceptional detection limit of 40 fM for the PSA cancer biomarker in whole blood serum.…”

Engineering plasmonic nanorod arrays for colon cancer marker detection

“…Recently, we have witnessed considerable efforts for the development of plasmonics and photonics-based nanosensors for biochemical and genetic analysis, especially for screening and rapid detection of cancer markers (Anker et al 2008;Cao et al 2013;Chao and Guo 2003;de la Rica and Stevens 2012;Fan et al 2010;Hao et al 2008;Luk'yanchuk et al 2010;Miroshnichenko et al 2010;Peng et al 2013;Rodriguez-Lorenzo et al 2012;Truong et al 2011;Verellen et al 2009;Wen et al 2013;Xu et al 2011;Zhang et al 2013). These systems provide a range of benefits such as shorter analysis time, lower consumption of sample, chemical reagent and energy, lower cost, and portability.…”

SOI-nanowire biosensor for the detection of D-NFAT 1 protein

“…Для этой цели в последнее время разрабатываются новые типы биосенсоров на основе нанотехнологий, в частности, сенсор на основе АСМ [1][2][3][4], оптические нанобиосенсоры [5][6][7][8], нанопроволочные биосенсоры [9,10]. Наибольший интерес для диагностики представляют нанопроволочные биосенсоры (НП-биосенсоры) в связи с тем, что они относятся к классу так называемых безметковых ("label-free") детекторов и позволяют проводить регистрацию макромолекул в режиме реального времени.…”