Plasmonic Photothermal Therapy of Transplanted Tumors in Rats at Multiple Intravenous Injection of Gold Nanorods

Bucharskaya, Alla B.; Maslyakova, Gаlina N.; Дихт, Н. И.; Navolokin, Nikita; Terentyuk, Georgy S.; Bashkatov, Alexey N.; Genina, Elina A.; Khlebtsov, Boris N.; Khlebtsov, Nikolai G.; Tuchin, Valery V.

doi:10.1007/s12668-016-0320-z

Cited by 15 publications

(12 citation statements)

References 22 publications

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“…The gold content in tumor tissue increased significantly compared to the groups with single and double IVI of GNRs. The temperature raising was comparable with PPT after direct intratumoral GNRs injection, as was found previously .…”

Section: Resultssupporting

confidence: 88%

Plasmonic photothermal therapy: Approaches to advanced strategy

et al. 2018

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Section: Resultssupporting

confidence: 88%

Plasmonic photothermal therapy: Approaches to advanced strategy

et al. 2018

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“…[25] it was shown that the direct intratumoural injection of GNR suspension with the concentration 400 µg/mL followed by the irradiation of tumours with laser light at the wavelength 808 nm led to the increase of temperature in the heating zone to 65.5 ± 5°C. With this method of injection, the maximal amount of nanoparticles was accumulated in tumour.…”

Section: Resultsmentioning

confidence: 99%

“…Fig. 1 Heating kinetics of experimental tumours and adjacent tissues stimulated by near-infrared radiation (the IT group comprises the rats subjected to a single intratumoural injection of GNR suspension with the concentration 400 µg/mL [25]). …”

Section: Resultsmentioning

confidence: 99%

Study of Tumour and Surrounding Tissue Heating with Near-Infrared Radiation after the Injection of Gold Nanoparticles into the Tissue

Genin

Genina

Bucharskaya

et al. 2018

J-BPE

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Abstract.We study the heating kinetics in transplanted model tumours after the intravenous injection of suspension of gold nanorods having the concentration from 400 to 1200 µg/mL under the laser irradiation at the wavelength 808 nm during 15 min. The object of study were 40 outbred white laboratory rats with transplanted liver cancer tumours (Cholangiocarcinoma PC1). The obtained results allow the optimisation of the gold nanorods injection technique at different degrees of vascularisation of tumour tissues aimed to provide the maximal heating of tumours by the laser radiation. It is shown that the maximal increase of the tumour temperature is related to the maximal accumulation of gold nanorods in the tumour tissues, observed in the case of its high vascularisation. © 2018 Journal of Biomedical Photonics & Engineering.Keywords: tumour; NIR laser irradiation; photothermal therapy; gold nanorods.

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“…Геометрические параметры ЗНС определяли по изображениям, полученным методом трансмиссионной электронной микроскопии на микроскопе Libra-120 (Carl Zeiss, Germany), длина и диаметр стержней составляли 41 ± 8 nm и 10 ± 2 nm соответственно; концентрация золота 400 µg/ml соответствовала оптической плотности 20 при 810 nm. Оставшимся в эксперименте крысам проводили трехкратное внутривенное введение покрытых ПЭГ ЗНС по разработанному нами ранее протоколу [11] и через сутки после последнего введения проводили ПФТ с использованием БИК лазера с длиной волны 808 nm и плотностью мощности излучения 2.3 W/сm 2 . Термографию локального нагрева опухоли проводили с использованием тепловизора IRYSYS 4010 (UK).…”

Section: материалы и методыunclassified

К Вопросу Об Эффективности Плазмонной Фототермической Терапии Экспериментальных Опухолей

Бучарская¹,

Маслякова²,

Чехонацкая³

et al. 2020

Журнал Технической Физики

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The aim of the study was to study the prognostic factors of the effectiveness of plasmon photothermal therapy (PPT) in rats with transplanted liver cancer based on an assessment of the degree of tumor vascularization. Prior to any exposure, rats with transplanted liver cancer RS-1 underwent a doppler ultrasonography to assess the degree of vascularization of the transplanted tumors. Half of the animals with transplanted tumors were removed from the experiment after dopplerography to determine the content of vascular factors in blood serum by immunoassay and immunohistochemical methods in tumor tissue. After triple intravenous administration of gold nanorods (GNRs) coated with polyethylene glycol at a dose of 0.4 mg/ml, the transplanted tumors were irradiated percutaneously with infrared laser radiation at a wavelength of 808 nm and a thermography of local tumor heating was conducted. After 24 hours, the animals were removed from the experiment and samples of tumor tissue were taken for histological examination. It was found that the accumulation of gold in the tumor tissue and the effectiveness of PPT after repeated intravenous administration of GNRs are determined by the presence of a formed vasculature in the tumor.

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Plasmonic Photothermal Therapy of Transplanted Tumors in Rats at Multiple Intravenous Injection of Gold Nanorods

Cited by 15 publications

References 22 publications

Plasmonic photothermal therapy: Approaches to advanced strategy

Plasmonic photothermal therapy: Approaches to advanced strategy

Study of Tumour and Surrounding Tissue Heating with Near-Infrared Radiation after the Injection of Gold Nanoparticles into the Tissue

К Вопросу Об Эффективности Плазмонной Фототермической Терапии Экспериментальных Опухолей

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