Plasticity of Neuron-Glial Interactions Mediated by Astrocytic EphARs

Nestor, Michael W.; Mok, Lee-Peng; Tulapurkar, Mohan E.; Thompson, Scott M.

doi:10.1523/jneurosci.2442-07.2007

Cited by 60 publications

(53 citation statements)

References 68 publications

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“…It has been reported that LTD in the Xenopus retinotectal system requires NO synthesis (Mu and Poo, 2006), suggesting that glial dynamics, which we have shown in this study to be NO-regulated, may participate in LTD. In support of this idea, in cultured hippocampal slices, ephrin-A3 presented by motile astrocytic processes has been implicated in regulation of synaptic morphology and function by inducing spine retraction (Murai et al, 2003;Nestor et al, 2007). Alternatively, as synapses are weakened by LTD, glial processes may be recruited to help redirect the axon to a more appropriate partner.…”

Section: Discussionmentioning

confidence: 96%

“…Glial processes in the brain have been shown to physically ensheath synaptic terminals in the hippocampus and cerebellum, where they actively participate in synapse formation, spine maturation, and synaptic plasticity (Murai et al, 2003;Christopherson et al, 2005;Panatier et al, 2006a;Stellwagen and Malenka, 2006;Todd et al, 2006;Jourdain et al, 2007;Nestor et al, 2007;Nishida and Okabe, 2007). In addition to interactions with synapses, rapid dynamic remodeling of astrocytes has been demonstrated in hippocampal cultures and in acute hindbrain slices (Hirrlinger et al, 2004;Haber et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Regulation of Radial Glial Motility by Visual Experience

Tremblay

Fugère²,

Tsui³

et al. 2009

J. Neurosci.

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Radial glia in the developing optic tectum express the key guidance molecules responsible for topographic targeting of retinal axons. However, the extent to which the radial glia are themselves influenced by retinal inputs and visual experience remains unknown. Using multiphoton live imaging of radial glia in the optic tectum of intact Xenopus laevis tadpoles in conjunction with manipulations of neural activity and sensory stimuli, radial glia were observed to exhibit spontaneous calcium transients that were modulated by visual stimulation. Structurally, radial glia extended and retracted many filopodial processes within the tectal neuropil over minutes. These processes interacted with retinotectal synapses and their motility was modulated by nitric oxide (NO) signaling downstream of neuronal NMDA receptor (NMDAR) activation and visual stimulation. These findings provide the first in vivo demonstration that radial glia actively respond both structurally and functionally to neural activity, via NMDAR-dependent NO release during the period of retinal axon ingrowth.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Regulation of Radial Glial Motility by Visual Experience

Tremblay

Fugère²,

Tsui³

et al. 2009

J. Neurosci.

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“…In cultures (Safavi‐Abbasi et al, 2001) as well as slices (Lippman et al, 2008; Nestor et al, 2007; Nishida and Okabe, 2007) astrocytic processes can adapt quickly to changes in their environment through a mechanism involving the GTPase Rac‐1. Moreover, expression of a dominant negative form of the actin‐binding protein profilin‐1 inhibited filopodia formation and motility (Molotkov et al, 2013).…”

Section: Molecular Machineries Of Astroglial Morphogenesis: Cytoskelementioning

confidence: 99%

Morphological plasticity of astroglia: Understanding synaptic microenvironment

Heller

Rusakov

2015

Glia

134

137

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Memory formation in the brain is thought to rely on the remodeling of synaptic connections which eventually results in neural network rewiring. This remodeling is likely to involve ultrathin astroglial protrusions which often occur in the immediate vicinity of excitatory synapses. The phenomenology, cellular mechanisms, and causal relationships of such astroglial restructuring remain, however, poorly understood. This is in large part because monitoring and probing of the underpinning molecular machinery on the scale of nanoscopic astroglial compartments remains a challenge. Here we briefly summarize the current knowledge regarding the cellular organisation of astroglia in the synaptic microenvironment and discuss molecular mechanisms potentially involved in use‐dependent astroglial morphogenesis. We also discuss recent observations concerning morphological astroglial plasticity, the respective monitoring methods, and some of the newly emerging techniques that might help with conceptual advances in the area. GLIA 2015;63:2133–2151

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“…However, its high expression level in different neuronal populations throughout the rodent and human brain Filosa et al, 2009;Grunwald et al, 2001;Murai et al, 2003a;Xiao et al, 2006), localization in both pre-and postsynaptic regions (Bouvier et al, 2008;Tremblay et al, 2007) and ability to interact with both A and B type ephrins (Pasquale, 2005) suggest that EphA4 has diverse roles in brain synapses. EphA receptors have also been detected in some astrocyte populations (Cahoy et al, 2008;Nestor et al, 2007;Tremblay et al, 2007), suggesting that the function of these receptors goes beyond regulating neuronal properties.…”

Section: Localization Of Eph Receptors and Ephrins At Synapsesmentioning

confidence: 99%

Eph receptors and ephrins in neuron–astrocyte communication at synapses

Murai

Pasquale

2011

Glia

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Neuron-glia communication is essential for regulating the properties of synaptic connections in the brain. Astrocytes, in particular, play a critical and complex role in synapse development, maintenance, and plasticity. Likewise, neurons reciprocally influence astrocyte physiology. However, the molecular signaling events that enable astrocytes and neurons to effectively communicate with each other are only partially defined. Recent findings have revealed that Eph receptor tyrosine kinases and ephrins play an important role in contact-dependent neuron-glia communication at synapses. Upon binding, these two families of cell surface-associated proteins trigger bidirectional signaling events that regulate the structural and physiological properties of both neurons and astrocytes. This review will focus on the emerging role of Eph receptors and ephrins in neuron-astrocyte interaction at synapses and discuss implications for synaptic plasticity, behavior, and disease.

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Plasticity of Neuron-Glial Interactions Mediated by Astrocytic EphARs

Abstract: ] in astrocytes. We conclude that ephrinA-EphA signaling is a pluripotent regulator of neuronastrocyte interactions mediating rapid structural and functional plasticity.

Cited by 60 publications

References 68 publications

Regulation of Radial Glial Motility by Visual Experience

Regulation of Radial Glial Motility by Visual Experience

Morphological plasticity of astroglia: Understanding synaptic microenvironment

Eph receptors and ephrins in neuron–astrocyte communication at synapses

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