Platelet adhesion before and after venous occlusion

Holzknecht, F; Spöttl, F; R, Constantini; Knapp, E; M, Herbst; Braunsteiner, H

doi:10.1016/0021-9150(70)90009-2

Cited by 9 publications

(1 citation statement)

References 29 publications

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“…Es konnte ein Anstieg der Faktoren V, VII, IX, XI und XII und des Antithrombin III durch VenenverschluB festgestellt werden [15,20,22,25], ferner eine Erh6hung des fibrinolytischen Potentials [1, 5,6,12] und der Adh~ision der Thrombozyten [13]. Ein m6glicher Zusammenhang einer ven6sen Stauung der unteren ExtremitS.ten bei kompletter Relaxation des narkotisierten Patienten auf dem Operationstisch mit dem Auftreten per-oder postoperativer thromboembolischer Komplikationen wurde diskutiert [3].…”

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Beeinflussung stasebedingter Änderungen des Gerinnungsmechanismus durch niedrig dosiertes Heparin und durch Azetylsalizylsäure

Vinazzer

Loew

1978

Blut

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The influence of venous occlusion on plasmatic coagulation, on platelets, and on fibrinolysis was examined. After occlusion, activated factors XI and X could be demonstrated. Simultaneously, platelet aggregation induced by both collagen and epinephrine was increased. Fibrinolysis was found to be moderately enhanced. In patients taking acetylsalicylic acid (ASA), platelet functions were not altered by occlusion but the activation of plasmatic clotting factors was not influenced. Low dose heparin inhibited plasmatic activation but had no influence on the increase of platelet activities. By simultaneous administration of both substances, an additive effect was observed resulting in inhibition of plasmatic and platelet activation due to venous occlusion.

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