Platelet function and coagulation studies in patients with mitral valve prolapse

Zuppiroli, Alfredo; Cecchi, Fabiola; Ciaccheri, M; Italiani, G.; Dolara, Alberto; Longo, Giada; Matucci, Marzia; Morfini, M; Rafanelli, Daniela

doi:10.1002/clc.4960091004

Cited by 16 publications

(12 citation statements)

References 30 publications

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“…28 Zuppiroli et al have shown that platelet function tests were found to be normal with the exception of platelet aggregation rate. 29 In their study, there was a significant rise in von Willebrand factor and fibrinopeptide A levels, suggesting the existence of a particular subset of patients with MVP with a higher risk for thromboembolic events. 29 We evaluated the platelet reactivity by measuring MPV.…”

Section: Discussionmentioning

confidence: 97%

“…29 In their study, there was a significant rise in von Willebrand factor and fibrinopeptide A levels, suggesting the existence of a particular subset of patients with MVP with a higher risk for thromboembolic events. 29 We evaluated the platelet reactivity by measuring MPV. Our findings are in accordance with those of previous studies.…”

Section: Discussionmentioning

confidence: 97%

“…Our findings are in accordance with those of previous studies. [27][28][29] It is well known that platelets play a key role in the development of thrombi. Thromboembolic events have been described in patients with MVP.…”

Section: Discussionmentioning

confidence: 99%

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Mean Platelet Volume may be Elevated in Mitral Valve Prolapse and Associated With the Severity of Prolapse

Icli

Aksoy

Doğan

et al. 2012

Clin Appl Thromb Hemost

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Thromboembolic events can be seen in patients with mitral valve prolapse (MVP). It is unclear whether platelet activation may contribute to these events in patients with MVP. Thus, we aimed to evaluate mean platelet volume (MPV) in patients with MVP and its association with the severity of MVP. This study included 312 patients with MVP and 240 control participants. Mean platelet volume was significantly higher in patients with MVP than in controls (8.9 ± 0.7 vs 7.9 ± 0.6 fL, P = .001). In linear regression analysis, MPV was independently associated with the degree of mitral regurgitation (β = .23, 95% confidence interval (CI): 0.14-0.32, P = .001), maximal leaflet displacement (β = .24, 95%CI: 0.17-0.31, P = .001), and mean thickness of the anterior (β = .47, 95%CI: 0.27-0.61, P = .001) and posterior leaflets (β = .22, 95%CI: 0.03-0.41, P = .02). Our findings show that MPV can be elevated in patients with MVP and may be independently associated with severity of mitral regurgitation, leaflet displacement, and thickness of the leaflets.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

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Mean Platelet Volume may be Elevated in Mitral Valve Prolapse and Associated With the Severity of Prolapse

Icli

Aksoy

Doğan

et al. 2012

Clin Appl Thromb Hemost

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“…One explanation for a high platelet count may be platelet fragmentation resulting from shear stress due to mitral regurgitation [2]. In addition, increased platelet reactivity has been reported in some human patients with mitral valve prolapse [22].…”

Section: Discussionmentioning

confidence: 99%

Serum nitrotyrosine concentration in dogs with myxomatous mitral valve disease

Kim¹,

Park²,

Park³

et al. 2017

Korean Journal of Veterinary Research

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The aim of this study was to compare serum nitrotyrosine concentrations in healthy dogs with those in dogs with myxomatous mitral valve disease (MMVD). Fifty client-owned dogs were included in this study. Based on echocardiographic results, dogs were categorized into healthy (control), mild-, moderate-, and severe-MMVD groups. Serum nitrotyrosine concentrations were determined from enzyme-linked immunosorbent assays. No significant difference between control dogs and dogs with mild MMVD was detected (p = 0.31). However, dogs with moderate MMVD had significantly higher serum concentrations of nitrotyrosine (p = 0.04) than that in controls, and dogs with severe MMVD had significantly lower serum concentrations of nitrotyrosine (p = 0.03) than that in moderate MMVD dogs. There were negative correlations in the association of serum nitrotyrosine with age (n = 30, R 2 = 0.067, p = 0.27), left atrial-to-aortic root diameter ratio (n = 30, R 2 = 0.02, p = 0.57), and platelet count (n = 30, R 2 = 0.39, p = 0.003); however, only the platelet correlation was significant. Among dogs with MMVD, there was no significant difference in serum nitrotyrosine concentration between males and females. The results of this study suggest that tyrosine nitration end-products might be potential biomarkers for the detection of MMVD in dogs.

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“…Previous studies have demonstrated increased platelet activation in patients with mitral regurgitation [3,19,20]. However, some opinions defending vice versa are also available [5].…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume, in predicting severity of mitral regurgitation and left atrial appendage thrombosis

Ulu

Özkeçeci²,

Akçi³

et al. 2014

Blood Coagulation &Amp; Fibrinolysis

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Platelet function and coagulation studies in patients with mitral valve prolapse

Cited by 16 publications

References 30 publications

Mean Platelet Volume may be Elevated in Mitral Valve Prolapse and Associated With the Severity of Prolapse

Mean Platelet Volume may be Elevated in Mitral Valve Prolapse and Associated With the Severity of Prolapse

Serum nitrotyrosine concentration in dogs with myxomatous mitral valve disease

Mean platelet volume, in predicting severity of mitral regurgitation and left atrial appendage thrombosis

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