Platelet reactivity in diabetic patients with invasive &lt;em&gt;Klebsiella pneumoniae&lt;/em&gt; liver abscess syndrome

Lee, Chen‐Hsiang; Chuah, Seng‐Kee; Tai, Wei‐Chen; Chen, I‐Ling

doi:10.2147/idr.s174913

Cited by 12 publications

(10 citation statements)

References 30 publications

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“…The most common routes of infection are biliary tract infection and hematogenous infection [ 19 ]. The clinical manifestations of patients with liver abscess include fever, nausea/vomiting, chills, liver pain, elevated white blood cell count, with or without hepatomegaly, and fatigue [ 20 , 21 ]. Currently, surgical treatment is advocated in clinical practice for attenuating the condition in which the puncture and drainage technique is widely used.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Prognosis of Ultrasound-Guided Percutaneous Catheter Drainage in Patients with Liver Abscess Complicated with Septic Shock

Luo

Wang

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. Currently, the therapeutic effect and outcomes of US-PCD in patients with liver abscess and septic shock remain unclear. This study is aimed at investigating the effects of ultrasound-guided percutaneous catheter drainage (US-PCD) on the prognosis of patients with liver abscess complicated with septic shock. Method. We retrieved and assessed the data of 120 patients with liver abscess complicated with septic shock diagnosed at our hospital from January 2019 to March 2021. The patients underwent US-PCD in the observation group or conventional surgical incision and drainage in the control group. After treatment, we determined the levels of liver function indicators alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), and alkaline phosphatase (ALP) as well as the levels of inflammatory cytokines IL-6, IL-8, and TNF-α in serum using ELISA on postoperative days 0, 2, 4, and 6. The postoperative body temperature recovery, peripheral white blood cell count recovery, extubation, postoperative length of stay, and complications were recorded, with a 12-month follow-up to calculate their survival rate. Results. After treatment, the ALT, AST, TBIL, DBIL, and ALP levels and inflammatory factor levels in the two groups were gradually reduced over time and returned to the normal range with a better recovery trend in the observation group. US-PCD was associated with better postoperative body temperature recovery, peripheral white blood cell count recovery, shorter extubation time, hospital stay, lower postoperative rate, and a higher survival rate. Conclusion. US-PCD may be effective in treating liver abscess and can significantly improve the prognosis of patients.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Prognosis of Ultrasound-Guided Percutaneous Catheter Drainage in Patients with Liver Abscess Complicated with Septic Shock

Luo

Wang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Aspirin has been reported to inhibit the production of KP CPS, which is important to its virulence because of its anti-phagocytic effect against macrophages and neutrophils 12,21 . Plateletmonocyte aggregation is also involved in the pathogenesis of KP-PLA in diabetic patients, which was shown to be decreased by aspirin 22 . www.nature.com/scientificreports/ In addition to aspirin use, our study revealed that taking clopidogrel reduced the risk of KP-PLA.…”

Section: Discussionmentioning

confidence: 99%

The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients

Tai

Hsu

Yang

et al. 2020

Sci Rep

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In this study, we aimed to investigate the impact of aspirin on the risk of pyogenic liver abscess caused by Klebsiella pneumoniae (KP-PLA) and invasive KP-PLA syndrome (IKPS) in diabetic patients. Diabetic patients who were propensity-score matched were retrospectively included from hospital-based database. Kaplan–Meier approach with a log-rank test was used to compare the cumulative incidences of KP-PLA including IKPS between aspirin users and non-users. Totally, 63,500 patients were analyzed after propensity-score matching (1:1). Compared with that of non-users, the incidence of KP-PLA was significantly reduced in aspirin users (0.31% vs. 0.50%, p < 0.01), but not for that of IKPS (0.02% vs. 0.03%, p = 0.29). Patients taking aspirin for ≥ 90 days had a significantly lower risk for KP-PLA (hazard ratio, 0.67; 95%CI, 0.50–0.90). Females, taking clopidogrel or metformin for ≥ 90 days, and taking H2-blockers or proton pump inhibitors (PPIs) for ≥ 5 days were also associated with a lower risk of KP-PLA. However, cholangitis and a glycated hemoglobin ≥ 8.5% were associated with an increased risk of KP-PLA.

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“…Diabetic patients admitted to KCGMH between January 1, 2013 and December 31, 2016 with community-acquired mono-microbial bacteremia caused by KP were included to determine the patients with KP-PLA recurrence 21 . PLA recurrence was defined as having a typical clinical presentation, with new imaging findings of abscess recurrence after the first episode of abscess had fully resolved.…”

Section: Methodsmentioning

confidence: 99%

Aspirin use is associated with reduced risk for recurrence of pyogenic liver abscess: a propensity score analysis

Liu

Lee

Chuah

et al. 2019

Sci Rep

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Aspirin possesses anti-bacterial activity that may prevent recurrence of Klebsiella pneumoniae pyogenic liver abscess (KP-PLA). In e x-vivo study, aspirin was administered before bactericidal assay against serotype K1 K. pneumoniae . We identified 5,912 patients with PLA who had no known pre-existing hepatobiliary diseases or malignancy in Taiwan from 1999 to 2013 from nationwide cohort study. Multivariate Cox proportional hazards regression models was used to estimate the hazard ratios [HR] for the association between aspirin use and recurrent PLA. The PLA recurrence rate in patients taking aspirin daily for 30 or more days, from 90 days before to 90 days after the first PLA episode (aspirin users), and aspirin non-users was 42.5 and 74.6 per 1,000 person-years of follow-up, respectively. The population-based study showed a HR for PLA recurrence in aspirin users of 0.50 (95% confidence interval, 0.35–0.69), relative to that in non-users, after adjustments for confounders. An ex-vivo study indicated that aspirin was able to significantly enhance bacterial killing by leukocytes, whether collected from diabetic patients with KP-PLA recurrence or from healthy volunteers. Our results suggest that aspirin is associated with reduced risk for PLA recurrence among Taiwanese with PLA who had no preexisting hepatobiliary diseases or malignancy.

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Platelet reactivity in diabetic patients with invasive <em>Klebsiella pneumoniae</em> liver abscess syndrome

Cited by 12 publications

References 30 publications

Efficacy and Prognosis of Ultrasound-Guided Percutaneous Catheter Drainage in Patients with Liver Abscess Complicated with Septic Shock

Efficacy and Prognosis of Ultrasound-Guided Percutaneous Catheter Drainage in Patients with Liver Abscess Complicated with Septic Shock

The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients

Aspirin use is associated with reduced risk for recurrence of pyogenic liver abscess: a propensity score analysis

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