Platelet-Rich Fibrin as a Grafting Material in Periapical Surgery: A Case Series

Kulkarni, Mihir R.; Mohan, Jatinder; Bakshi, Purva Vijay

doi:10.11607/prd.3510

Cited by 10 publications

(9 citation statements)

References 5 publications

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“…Torres et al [54] also reported 28.5% of their cases in a control group suffering from mesh exposure while in a PRP group, no exposures were registered. The success of PRF may be due to the role of fibrin in initial clot stabilization [22]. PRF as a biodegradable scaffold consisting of stem cells, fibrin, platelets and leucocytes boosts microvascularization and epithelial cell migration [55,56].…”

Section: Discussionmentioning

confidence: 99%

“…Treatment opportunities like self-inflating soft tissue expanders [19] or free fat grafts (FFG) from the buccal fat pad [20] aiming to stabilize the soft tissue healing process increase comorbidity of the patient and need additional surgical skills. A promising solution may be the enhancement of soft tissue wound healing by Platelet-Rich Fibrin (PRF) as shown in literature [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Minimizing risk of customized titanium mesh exposures – a retrospective analysis

Hartmann

Seiler

2020

BMC Oral Health

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Background: Recommendations for soft tissue management associated with customized bone regeneration should be developed. The aim of this study was to evaluate a new protocol for customized bone augmentation in a digital workflow. Methods: The investigators implemented a treatment of three-dimensional bone defects based on a customized titanium mesh (Yxoss CBR®, ReOSS, Filderstadt, Germany). Patients and augmentation sites were retrospectively analysed focussing on defect regions, demographic factors, healing difficulties and potential risk factors. An exposure rate was investigated concerning surgical splint application, A®-PRF and flap design. Results: In total, 98 implants could be placed. Yxoss CBR® was removed after mean time of 6.53 ± 2.7 months. Flap design was performed as full flap preparation (27.9%), full flap and periosteal incision (39.7%), periosteal incision (1.5%), poncho/split flap (27.9%) and rotation flap (2.9%). In 25% of the cases, exposures of the meshes were documented. Within this exposure rate, most of them were slight and only punctual (A = 16.2%), like one tooth width (B = 1.5%) and complete (C = 7.4%). A®-PRF provided significantly less exposures of the titanium meshes (76.5% no exposure vs. 23.5% yes, p = 0.029). Other parameters like tobacco abuse (p = 0.669), diabetes (p = 0.568) or surgical parameters (mesh size, defect region, flap design) did not influence the exposure rate. Surgical splints were not evaluated to reduce the exposure rate (p = 0.239). Gender (female) was significantly associated with less exposure rate (78,4% female vs. 21.6% male, p = 0.043). Conclusions: The results of this study suggest that the new digital protocol including patient-specific titanium meshes, resorbable membranes and bone grafting materials was proven to be a promising technique. To improve soft tissue healing, especially A®-PRF should be recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Minimizing risk of customized titanium mesh exposures – a retrospective analysis

Hartmann

Seiler

2020

BMC Oral Health

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“…Studies with similar methodologies, such as Singh et al, 31 Angerame et al, 32 and Kulkarni et al 33 showed that bone repair of the surgical pocket using L-PRF membranes was effective. However, the evaluation methods in the literature differ from this work; namely, digital periapical radiographs were used.…”

Section: Discussionmentioning

confidence: 96%

“…CBCT is able to detect imaging of periapical lesions before they are apparent on conventional radiography. [33][34][35] Clinical studies have shown that periapical lesion imaging was detected in 20% of cases and 48% in CBCT. 36 In vivo studies where simulations of bone stores of periapical lesions were performed showed similar results.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Bone Repair After Periapical Surgeries Using Leukocyte Platelet-Rich Fibrin (L-PRF) and Blood Clot: A Double-Blind Clinical Trial

Pessoa

Gasparello

Ignácio

et al. 2022

Preprint

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This study evaluated the effectiveness of the use of an autologous membrane of fibrin rich in platelets and leukocytes (LPRF) and blood clot, in bone repair after periapical surgery, in teeth with apical lesions. Methodology: Randomized clinical study of 64 teeth with periapical lesions submitted to apicectomy and retrograde filling with mineral trioxide aggregate (MTA). The teeth were divided into 2 groups according to the filling of the bone pocket: LPRF (n = 34) and only with blood clot (n = 30). The areas were measured twice, T0 after periapical surgery and T1 after 90 days, using cone beam computed tomography (CBCT) to assess bone pocket repair in cubic millimeters using the ITK-SNAP program. Results: Statistical analyses revealed significant reductions in the volume of bone stores in the LPRF group, with a 48.47% reduction compared to 29.25% for the blood clot group (p < 0.01), with the power of test at 99.86%. Conclusion: The use of LPRF membrane can be recommended as a bone site filler after periapical surgery compared to blood clot.

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“…It has easy and moisture independent application, biocompatibility, superior seal and ability to strengthen the root. 6 With time, a new cementum deposition was found on the surface of the material. Literature reviews higher success rate in follow-up studies with MTA as root-end filling material.…”

Section: Discussionmentioning

confidence: 99%

Salvage through endodontic surgical management: A case report

Sharma¹,

Gupta²,

Bansal³

et al. 2021

IJCE

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The aim of this report is to discuss a case about a failed root canal treated upper right lateral incisor presented with chronic periapical pathology with extruded guttapercha. Apicoectomy involves surgical management of a tooth with a periapical lesion, which cannot be resolved by routine endodontic treatment. The goal of apical surgery is to prevent leakage of bacteria and their byproducts from the root canal system into peri-radicular tissue. With the advancements in magnification, armamentaria and materials, the success rate of treatment outgrows. Hence, present study describes a case of retreatment successfully treated by endodontic periapical surgery.

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Platelet-Rich Fibrin as a Grafting Material in Periapical Surgery: A Case Series

Cited by 10 publications

References 5 publications

Minimizing risk of customized titanium mesh exposures – a retrospective analysis

Minimizing risk of customized titanium mesh exposures – a retrospective analysis

Evaluation of Bone Repair After Periapical Surgeries Using Leukocyte Platelet-Rich Fibrin (L-PRF) and Blood Clot: A Double-Blind Clinical Trial

Salvage through endodontic surgical management: A case report

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