Platelet rich fibrin in the management of established dry socket

Abstract

ObjectivesDry socket may occur secondary to the removal of any tooth. However, most dry socket cases develop in the third molar region. Dry socket is multifactorial in nature and has been treated using various modalities with varying success rates. This study assessed the efficacy of platelet rich fibrin (PRF) in established dry socket.Materials and MethodsTen patients of either sex aged from 41 to 64 years with established dry socket according to established criteria were treated using PRF. Evaluation was performed by observing the reduction of pain using visual analogue scale, analgesic tablet use over the follow-up period, and healing parameters.ResultsPain was reduced on the first day in all patients with decreased analgesic use. Pain was drastically reduced during follow-up on the first, second, third, and seventh days with a fall in pain score of 0 to 1 after the first day alone. The pain scores of all patients decreased to 1 by the first day except in one patient, and the scores decreased to 0 in all patients after 48 hours. Total analgesic intake ranged from 2 to 6 tablets (aceclofenac 100 mg per tablet) over the follow-up period of 7 days. Healing was satisfactory in all patients by the end of the seventh day.ConclusionPRF showed early pain reduction in established dry socket with minimal analgesic intake. No patients had allergic reactions to PRF as it is derived from the patient's own blood. PRF showed good wound healing. Our study suggests that PRF should be considered as a treatment modality for established dry socket.

Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis

“…11,47 For quantitative analysis 13 articles were included, 9 articles about third molar 8, 25, 26, 28, 29, 32, 48-50 , 2 articles about sinus lift 35, 38 and 2 articles about dental implants 46, 51 . Seventeen articles were excluded and the reasons for exclusion were as follows: 4 non-randomized controlled clinical trial 52-55 ; 4 studies which outcomes of interest were not reported [56][57][58][59] ; 2 studies that used other PRF protocol 60,61 ; 1 study which did not test PRF 62 ; 1 retrospective study 63 ; 2 prospective studies 64,65 ; 1 study that used the same patients sample as other studies 66 ; 1 full text was not found 67 ; and 1 study was written in persa and not translated 68 . The value of Kappa was 0.84, thus it was considered an excellent agreement.…”

The Efficacy of Concentrated Growth Factor in the Healing of Alveolar Osteitis: A Clinical Study

“…Together, this cocktail of growth factors speeds up the development of the delicate fibrovascular granulation tissue. Different studies have shown that the presence of growth factors can speed up the healing process [44,45]. CGF promotes cell proliferation and migration and regulates the biological behavior of diverse cell types and supports angiogenesis which is a key element in any wound healing process [27].…”

Assessment of healing using alvogyl and platelet rich fibrin in patients with dry socket - An evaluative study

“…The findings of the present study are in conjunction with the studies done by Sam Paul et al .,[ 18 ] Ravi Bhujbal et al .,[ 19 ] Ashish Sharma et al .,[ 20 ] Srinivas Chakravarthi,[ 21 ] and Ivan Chenchev,[ 22 ] all of whom have concluded that PRF can be successfully used in the treatment of dry socket.…”