Platelet-rich fibrin or platelet-rich plasma – which one is better? an opinion

Bansal, Shweta; Garg, Arun; Khurana, Richa; Chhabra, Parul

doi:10.4103/ijds.ijds_55_17

Cited by 15 publications

(15 citation statements)

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“…Водночас неповна характеристика протоколів приготування PRF, відсутність чіткої їх класифікації і стандартизації значно ускладнює (навіть порівняно з PRP, у якій можна підрахувати кількість клітин (de Almeida et al, 2018), систематизацію та порівняння існуючих результатів досліджень, що зумовлює дискусію щодо біолікувальної ефективності кожного фактора росту за певних нозологічних форм патології (Bansal et al, 2017).…”

Section: вступunclassified

Histological characteristics of Platelet-Rich Fibrin clots obtained under various modes of blood centrifugation

Shevchenko

Rublenko

2020

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Autologous products of the first and second generation, namely platelet-rich plasma and platelet-rich fibrin, are considered promising for regenerative medicine. They differ from each other in physical properties, as well as in the way they are obtained. The key procedure of all techniques is centrifugation; changing its parameters affects the biological properties of these biomaterials. The aim of the work is to determine and histologically characterize the area of concentration cells of autologous fibrin enriched with platelets, depending on the change in centrifugation parameters. The studies were carried out on rabbits. Blood was collected and platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) were obtained using different values of relative centrifugal force: 100 g, 400 g, 735 g, 906 g, 1843 g. Due to the fact that it is impossible to determine the number of platelets in PRF clots, the counting was performed in platelet-rich plasma obtained by a single centrifugation with the corresponding parameters that were used to obtain PRF. The length of the formed clots was compared and a histological assessment of the cell composition in different layers (lower, middle and upper) was carried out. The highest platelet concentrations were observed in PRP obtained at 100 g and 400 g. Application of different values of centrifugal force showed obvious differences in the formation of platelet-rich fibrin clots. After preparation of I-PRF, its volume was significantly less than that of standard PRF, and the border between erythrocytes was less distinct. During the histological examination of fibrin clots, a change in the distribution of cellular elements in different parts was found with a change in the centrifugation parameters. With an increase in the parameter of relative centrifugal force, the length of the fibrin clot significantly increases, but the concentration of platelets in it significantly decreases. That is, it was found that the most optimal value of the relative centrifugal force for obtaining platelet mass is 100 g, which makes it possible to achieve the number of platelets greater than 800×109/L.

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Section: вступunclassified

Histological characteristics of Platelet-Rich Fibrin clots obtained under various modes of blood centrifugation

Shevchenko

Rublenko

2020

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“… 25 As a result, the PRF membrane used in extraction sockets has been shown to stimulate local soft tissue healing of gums and reduce the postoperative pain response. 26 …”

Section: Discussionmentioning

confidence: 99%

The effects of platelet-rich fibrin on post-surgical complications following removal of impacted wisdom teeth: A pilot study

Nourwali¹

2021

Journal of Taibah University Medical Sciences

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Objectives Platelet-rich fibrin (PRF) is a fibrin matrix composed of cells, cytokines, and growth factors, which may be liberated from blood at specific times and act as a resorbable membrane. Many studies have demonstrated the benefits of PRF for bone healing in oral and maxillofacial implant surgery. Our study assesses the impact of PRF on postoperative complications following the extraction of impacted wisdom teeth. Methods Twenty patients were recruited in this blind controlled randomised clinical trial, i.e. ten patients in the study group and ten patients in the control group. The patients were aged between 18 and 40 years. Surgical removal of impacted teeth #38 and #48 was performed in all the patients. The study group underwent dentoalveolar surgery with the use of PRF, while the control group underwent surgery without PRF. Results All patients in the study group reported significantly less postoperative pain ( p = 0.02) and excellent soft tissue healing during the follow-up period ( p = 0.021). In contrast, only 80% of patients in the control group exhibited sufficient soft tissue healing. The difference in postoperative swelling between the two groups was not statistically significant. Additionally, 69% of patients in the study group reported comfortable night sleep during the first 24 h after the operation compared to 31% in the control group. This difference was statistically significant (p = 0.02). Conclusion Based on the outcomes of our study, implanting PRF into surgical extraction sites can be helpful in reducing postoperative pain and improving soft tissue healing. The use of PRF in extraction sockets is simple and biologically safe. The beneficial effects of PRF support its possible application in the field of dental surgery.

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“…Суттєва роль у репаративному остеогенезі належить тромбоцитам (Zhang et al, 2012;Saikrishna & Yelamali, 2015;Burianov et al, 2017;Ho-Shui-Ling et al, 2018;Chatterjee & Debnath, 2019;Kornsuthisopon et al, 2020) завдяки дії їх паракринних біомолекулфакторів росту та цитокінів (Bansal et al, 2017;Shevchenko et al, 2019), які виконують певну роль у процесах відновлення пошкоджених структур: запаленні, синтезі колагену та ініціації ангіогенезу (Pascale et al, 2015;Neiva et al, 2016). Власне завдяки цьому перспективними у наданні остеокондуктивним матеріалам остеоіндуктивних і остеогенних властивостей вважаються різні технологічні варіанти аутологічних тромбоцитарних матеріалів.…”

Section: вступunclassified

“…Це -ідеальна стратегія для заміщення значних кісткових дефектів (Bansal et al, 2017;Ho-Shui-Ling et al, 2018;Chou et al, 2020). Зокрема, деякі тромбоцитарні фактори росту досить активно задіяні у регенерації кісток: основний фактор росту фібробластів індукує проліферацію та диференціювання преостеобластів; інсуліноподібний фактор росту (IGF-1) стимулює експресію лужної фосфатази, остеопонтину та остеокальцину в стромальних клітинах кісткового мозку; тромбоцитарний фактор росту (PDGF) може мати позитивний ефект на кісткову регенерацію через мітогенну активність та синергію з трансформуючим фактором росту (TGF-β1).…”

Section: результати та їх обговоренняunclassified

Histomorphological characteristics of bone replacement in rabbits with hydroxyapatite ceramics and Platelet-Rich Fibrin

et al. 2021

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The results of a histomorphological study of bone regenerates in rabbits after osteosubstitution with platelet-rich fibrin and its combination with hydroxyapatite granules with β-tricalcium phosphate in spongy and compact bone tissue at different periods of reparative osteogenesis are presented. Three groups of rabbits were formed. In the control group, the defects were left to heal under the blood clot. Bone lesions in the first experimental group were filled with platelet-rich fibrin, in the second – with a combination of platelet-rich fibrin and hydroxyapatite with β-tricalcium phosphate. All animals were kept in the same conditions of feeding and housing, had unlimited access to water. During the study, the rabbits were monitored clinically. The animals were taken out of the experiment on the 14th, 21st and 42nd days, samples of bone tissue were taken, they were fixed, decalcified, dehydrated in alcohols of increasing concentration and embedded in paraffin. In the presented study, it is most likely that the newly formed bone tissue is formed precisely due to osteoinduction in the experimental groups. When using granules of hydroxyapatite and β-tricalcium phosphate with platelet-rich fibrin, bone regenerate is between the composite granules and is not associated with contact with the maternal bone. Its cells appear in different places of the defect. In the spongy bone tissue on the 21st day, regeneration proceeded more fully and faster in the second experimental group, as evidenced by the significant density of cells of the osteoblastic row, the thickness of the bone trabeculae and their volume, filling the site of the defect. On the 42nd day, in the second experimental group, when using a combination of autobiomaterial and hydroxyapatite granules with β-tricalcium phosphate, the regenerate contained a significantly larger number of osteogenic cells in the thickness of the trabeculae, which indicated a more intensive course of reparative osteogenesis in comparison with the first experimental and control groups. In the compact bone on day 21, regeneration was more complete and faster in the second experimental group. On the 42nd day, according to the degree of maturity of the bone regenerate, calcium-phosphate ceramics in combination with platelet-rich fibrin optimizes reparative osteogenesis most clearly. According to the degree of intensity of the osteoregeneration process, the groups can be placed in the following sequence: control ˂PRF˂PRF+HA/β-TCP–700. According to histomorphological characteristics, the combination of hydroxyapatite with β-tricalcium phosphate and platelet-rich fibrin gives greater osteoinduction to the composite material, which is confirmed by the high cell density, namely of osteoblasts and osteocytes. The use of PRF in combination with other materials may become promising for the correction of reparative osteogenesis in conditions of limited or reduced regenerative potential of bone tissue.

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Platelet-rich fibrin or platelet-rich plasma – which one is better? an opinion

Cited by 15 publications

References 4 publications

Histological characteristics of Platelet-Rich Fibrin clots obtained under various modes of blood centrifugation

Histological characteristics of Platelet-Rich Fibrin clots obtained under various modes of blood centrifugation

The effects of platelet-rich fibrin on post-surgical complications following removal of impacted wisdom teeth: A pilot study

Histomorphological characteristics of bone replacement in rabbits with hydroxyapatite ceramics and Platelet-Rich Fibrin

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