Platelet-rich plasma in fibrin matrix to augment rotator cuff repair: a prospective, single-blinded, randomized study with 2-year follow-up

Walsh, Michael R.; Nelson, Bradley J.; Braman, Jonathan P.; Yonke, Bret; Obermeier, Michael; Raja, Avais; Reams, Megan

doi:10.1016/j.jse.2018.05.003

Cited by 31 publications

(21 citation statements)

References 28 publications

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“…The prevalence of symptomatic and asymptomatic RCT increases as we age. The pain and functional restrictions of the patients also increase [ 28 ]. Although improvement in symptoms can be seen after arthroscopic rotator cuff repair, the healing failure (retear) rate can be as high as 94% [ 5 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healing

Jeong

Khil

Kim

et al. 2021

Clin Shoulder Elbow

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Background: This study aimed to evaluate the co-administration effect of atelocollagen combined with hyaluronic acid (HA) injections for treatment of full-thickness rotator cuff tear (RCT).Methods: Eighty patients who underwent arthroscopic rotator cuff repair for full-thickness RCT from March 2018 to November 2019 were enrolled. The patients were randomly allocated to the following groups: combined atelocollagen and HA injection (group I, n=28), only HA injection (group II, n=26), and no injection (group III, n=26). Clinical outcomes were assessed at 3, 6, and 12 months after surgery using the American Shoulder and Elbow Surgeons score, visual analog scale pain, functional scores (pain visual analog scale, function visual analog score), and range of motion. Magnetic resonance imaging was performed 12 months after surgery to evaluate rotator cuff integrity.Results: Preoperative demographic data and postoperative clinical outcomes did not differ significantly among the three groups (p>0.05). However, in group I, the number of steroid injections after surgery was significantly lower than that in the other groups (p=0.011). The retear rate on follow-up magnetic resonance imaging was significantly higher in group II (9.5%, n=2) and group III (13.6%, n=3) than in group I (0%) (p=0.021).Conclusions: Co-administration of atelocollagen and HA improves healing of the rotator cuff and increases the integrity of the rotator cuff repair site. This study provides encouraging evidence for use of combined atelocollagen-HA injections to treat patients with full-thickness RCT.

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Section: Discussionmentioning

confidence: 99%

Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healing

Jeong

Khil

Kim

et al. 2021

Clin Shoulder Elbow

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“…Follow-up radiological evaluation of the tendons was performed by MRI at least 6 months after injection in our study. Many studies have looked at tendon integrity by MRI at 6 months after treatment, 12,13,28 so we considered radiological examination at 6-month follow-up sufficient to evaluate the integrity of the injected tendon. Fourth, a learning curve was required to accurately inject atelocollagen inside the tear site under ultrasonography.…”

Section: Discussionmentioning

confidence: 99%

Atelocollagen Injection Improves Tendon Integrity in Partial-Thickness Rotator Cuff Tears: A Prospective Comparative Study

Kim

et al. 2020

Orthopaedic Journal of Sports Medicine

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“…Wir untersuchten 2 doppelblinde RCT [36,37], 4 RCT [38][39][40][41], eine Kohortenstudie [42] und eine Fall-Kontroll-Studie ([43]; . Tab.…”

Section: Nutzen Von P-prfunclassified

Plättchenkonzentrate in der Behandlung von Rotatorenmanschettenläsionen

et al. 2021

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Zusammenfassung Hintergrund Trotz stetiger Verbesserungen bei der Refixationstechnik von Rotatorenmanschettenrupturen (RMR) ist die Rerupturrate mit 26,6 % nach wie vor hoch. Aus diesem Grund wird heute deshalb versucht, die Manschettenheilung zusätzlich mit biologischen Mitteln zu augmentieren. In diese Kategorie fällt die Augmentation mittels Plättchenkonzentraten. Neben der einfachen Gewinnung und Herstellung gibt es für diese autolog gewonnenen Konzentrate relativ tiefe regulatorische Hürden. Dass diese Konzentrate nur Minuten nach der Blutentnahme und Zentrifugation wieder appliziert werden können, ist ein weiterer Vorteil. Der Begriff Plättchenkonzentrate stellt eine große inhomogene Gruppe von verschiedenen Konzentraten mit unterschiedlichen Eigenschaften dar. Bedingt durch unterschiedliche Herstellungsprozesse weist nicht jedes Plättchenkonzentrat die gleichen Eigenschaften auf. Fragestellung Ist die biologische Augmentation mit Plättchenkonzentraten bei Rotatorenmanschettenläsionen mit einem verbesserten Outcome verbunden? Wie unterscheiden sich die gängigen Plättchenkonzentratprodukte in ihrem klinischen und radiologischen Resultat? Material und Methoden Die Suche fand via PubMed mit Einschluss von 26/289 Studien von 2007 bis 2020 statt. Ergebnisse und Diskussion Die Evaluation der heute verfügbaren Studien zeigt, dass nur P‑PRP („pure platelet-rich plasma“) zur biologischen Augmentation von RMR-Refixationen empfohlen werden kann. Hier zeigte sich eine signifikant tiefere Rerupturrate in den P‑PRP-Gruppen. Aber auch in dieser Plättchenuntergruppe sind die Resultate heterogen. Bei der konservativen Therapie von Partialrupturen und Tendinopathien der Manschette zeigt sich kein Benefit nach biologischer Augmentation mittels Plättchenkonzentrate.

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Platelet-rich plasma in fibrin matrix to augment rotator cuff repair: a prospective, single-blinded, randomized study with 2-year follow-up

Cited by 31 publications

References 28 publications

Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healing

Effect of co-administration of atelocollagen and hyaluronic acid on rotator cuff healing

Atelocollagen Injection Improves Tendon Integrity in Partial-Thickness Rotator Cuff Tears: A Prospective Comparative Study

Plättchenkonzentrate in der Behandlung von Rotatorenmanschettenläsionen

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