Platelet-rich plasma: The journey so far !

Kaushik, Akanksha; Kumaran, Muthu Sendhil

doi:10.4103/idoj.idoj_369_19

Cited by 28 publications

(12 citation statements)

References 56 publications

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“…PRP is an autologous blood product in which a small amount of peripheral blood is obtained aseptically and centrifuged to concentrate platelets in plasma, the concentration of which depends on different centrifugation equipment, gravity, and centrifugation time as well as on the individual patient. [11–14] Platelets α -granules (e.g., TGF- β 1, PDGF, bFGF, VEGF, EGF, IGF-1) contain large amounts of growth factors, which are concentrated and injected into the knee joint to promote tissue healing, such as cartilage repair, bone, and vascular remodeling, and involvement in inflammation regulation. [10,15] In recent years, PRP for KOA has become increasingly common in clinical practice and is a more promising treatment, but there are no clear conclusions about the role of PRP in KOA, and further high-quality studies are needed.…”

Section: Introductionmentioning

confidence: 99%

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Research trends of platelet-rich plasma therapy on knee osteoarthritis from 2011 to 2021: A review

et al. 2023

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Background: Platelet-rich plasma (PRP) has been widely used to alleviate osteoarthritis of the knee, and research results are abundant. However, there are no bibliometric reports in publications in this field. Therefore, the current status of PRP for the treatment of osteoarthritis of the knee from 2011 to 2021 was analyzed using Citespace 6.1.R2 software. Methods: Publications regarding PRP treating Knee Osteoarthritis between 2011 and 2021 were extracted from the Web of Science database. CiteSpace was used to analyze the number of publications, countries, institutions, journals, authors, cited references, and keywords by using standard bibliometric indicators. Results: A total of 988 publications were searched from 2011 to 2021. In the last decade, the number of publications has increased in the field. Brian J. Cole was the author with the most output, with 31 relevant articles, and Giuseppe Filardo ranked first in cited authors. Am J Sport Med was the most cited journal. In this field, the most prolific country is the United States and the most prolific institution is Rush University. An article published by Sandeep Patel ranked first in cited references with 118 citations. “Randomized controlled trial” was the most bursting keyword and other more popular keywords about PRP for knee osteoarthritis: “hyaluronic acid,” “double-blind,” and “mesenchymal stem cell.” Conclusion: This bibliometric study provides a decade of current clinical research on PRP for the treatment of osteoarthritis of the knee, which can help researchers understand the hot spots in the field and provide a new direction for their research.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Research trends of platelet-rich plasma therapy on knee osteoarthritis from 2011 to 2021: A review

et al. 2023

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“…One of the approaches is the use of peripheral blood-platelet lysate (PB-PL), which has been applied in certain medical fields such as dentistry and oral implantation, ophthalmology, sports medicine, cosmetics and dermatology, and the treatment of ulcers and soft tissue defects [ 9 ]. PB-PL is rich in growth factors that can be found in α-granules of adult blood platelets, which include vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), transforming growth factor-beta (TGF-β), and insulin-like growth factor 1 (IGF-1) [ 10 , 11 ]. Previous research has shown that PB-PL can accelerate the proliferation of cultured cells compared to fetal blood serum (FBS) in supporting the cell culture by increasing mRNA regulation for proto-oncogene protein transcription factors, sex-determining region Y, and Kruppel-like factor 4 [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Platelet Lysate Gels Derived from Different Blood Sources on Oral Mucosal Wound Healing: An In Vitro Study

Azhar

Budin

et al. 2023

Gels

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The rapid healing of oral ulcers is important to prevent secondary infection, especially for chronic oral ulcers. Platelet lysate (PL) is rich in growth factors for cell growth and promotes tissue regeneration. Hence, this study was performed to compare the effects of PL originating from umbilical cord blood (CB) and peripheral blood (PB) on oral mucosal wound healing. The PLs were molded into gel form in the culture insert with the addition of calcium chloride and conditioned medium for sustained release of growth factors. The CB-PL and PB-PL gels were found to degrade slowly in culture and their degradation percentages by weight were 5.28 ± 0.72% and 9.55 ± 1.82% respectively. The results from the scratch assay and Alamar blue assay showed that the CB-PL and PB-PL gels increased the proliferation (148 ± 3% and 149 ± 3%) and wound closure (94.17 ± 1.77% and 92.75 ± 1.80%) of oral mucosal fibroblasts compared to the control with no statistical differences between the two gels, respectively. Quantitative RT-PCR showed that mRNA expressions of collagen-I, collagen-III, fibronectin, and elastin genes in cells treated with CB-PL (11-, 7-, 2-, and 7-fold) and PB-PL (17-, 14-, 3-, and 7-fold) decreased compared with the control, respectively. The concentration of platelet-derived growth factor of PB-PL gel (1303.10 ± 343.96 pg/mL) showed a higher trend than CB-PL gel did (905.48 ± 69.65 pg/mL) from ELISA measurement. In summary, CB-PL gel is as effective as PB-PL gel in supporting oral mucosal wound healing, making it a potential new source of PL for regenerative treatment.

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“…5 Platelet-rich plasma (PRP) is a novel blood-derived product that attracted attention in different regenerative fields, especially in wound healing. 6,7 Theoretically, platelets are inseparable components of the physiology of wound healing due to their containing factors and products. 8,9 So applying a high volume of platelets at the wound site may facilitate the healing process, especially in non-healing wounds.…”

Section: Introductionmentioning

confidence: 99%

Platelet‐rich plasma improves acute and chronic anal fissure, a randomized control trial

Ebrahimibagha

Zeinalpour

2023

Wound Repair Regeneration

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Anal fissure is one of the most prevalent diagnosis in patients with anorectal symptoms. Depending on the chronicity, treatment choices vary, from topical and conservative management to operative ones. PRP is a blood‐derived product with a three to five‐fold platelet count and can be used for restorative purposes. The objective of this study is to assess the therapeutic effect of intralesional PRP in acute and chronic anal fissures and comparing it with the classic topical approach. We included 94 patients with acute and chronic anal fissures and divided them into intervention and control groups. Control patients were treated only with topical compounds, and the intervention group received one dose of intralesional autologous PRP plus the same classic treatment. We assessed patients 2 weeks, 1 month, and 6 months later. The mean pain score in the intervention group was significantly lower than control groups in all visits (p‐value <0.001). During the follow‐ups, the bleeding rate was significantly lower in the intervention group, so in the sixth month, the bleeding was 4% in the intervention group against 32% of the control (p‐value <0.001). The healing rate assessed by examination was 96% in the intervention group against 66% in the control in the sixth month (p‐value <0.001). Although there may be no significant difference in healing rate between groups in the acute anal fissure, the PRP group is significantly superior in the chronic setting. We concluded that in anal fissure treatment, PRP plus topical products are significantly superior to alone topical treatment.

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Platelet-rich plasma: The journey so far !

Cited by 28 publications

References 56 publications

Research trends of platelet-rich plasma therapy on knee osteoarthritis from 2011 to 2021: A review

Research trends of platelet-rich plasma therapy on knee osteoarthritis from 2011 to 2021: A review

Effects of Platelet Lysate Gels Derived from Different Blood Sources on Oral Mucosal Wound Healing: An In Vitro Study

Platelet‐rich plasma improves acute and chronic anal fissure, a randomized control trial

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