Platycarya strobilacea S. et Z. Extract Has a High Antioxidant Capacity and Exhibits Hair Growth-promoting Effects in Male C57BL/6 Mice

Kim, Eun Jin; Choi, Joo Yeon; Park, Byung Cheol; Lee, Bog‐Hieu

doi:10.3746/pnf.2014.19.3.136

Cited by 15 publications

(11 citation statements)

References 29 publications

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“…The research on herbs and active constituents as hair growth promoters has been driven by their less toxicity, easy availability, low‐cost, patient compliance and more than one mode of biochemical action . Specific effects of herbal extracts, polyherbal formulations, flavonoids and natural compounds on DPCs have been examined . In vivo hair growth promoting effects as proof of concept are also mentioned.…”

Section: Hair Growth Promoting Effectmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

127

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Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The in vitro models to investigate hair growth utilize the hair follicle Dermal Papilla cells (DPCs), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing DPCs as in vitro model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet-rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid-nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress-serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in DPCs. Effects on DPCs' activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end-point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up-to-date information and understanding regarding DPCs based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of DPCs in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.

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Section: Hair Growth Promoting Effectmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

127

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“…In contrast, TGF-β1 is involved in the regulation of hair follicle regression by inducing apoptosis and inhibiting keratinocyte proliferation and in the maintenance of niche of hair follicle stem cells (Mesa et al, 2015). Several plant extracts promote hair growth by regulating the expression of hair-growth-related cytokines (Kim et al, 2014;Shin et al, 2016). In the present study, resveratrol and fisetin increased the expression of IGF-1 and KGF, and decreased that of TGF-β1, in HaCaT cells, thereby promoting hair growth.…”

Section: Involvement Of Cytokines In Polyphenol-induced Hair Growth Pmentioning

confidence: 40%

“…Various plant extracts and chemicals with hair-growth-stimulating effects have been reported. Although precise underlying mechanisms remain unknown, these extracts and chemicals are considered to elicit these effects by accelerating blood flow, inducing a shift from telogen to anagen, mediating activation of the dermal papilla, inhibiting dihydrotestosterone, and exerting anti-inflammatory effects ( Junlatat and Sripanidkulchai, 2014 ; Kim et al, 2014 ; Park et al, 2017 ; Shen et al, 2018 ; Zhang et al, 2019 ; Zhou et al, 2020 ). The hair follicle contains several different types of cells; among these, the dermal papilla cells are major components of hair that play a critical role in inducing anagen phase and maintaining hair growth.…”

Section: Discussionmentioning

confidence: 99%

“…Six-week-old male C57BL/6 mice were obtained from Clea Japan (Tokyo, Japan) and allowed to adapt for a week, with food and water provided ad libitum. The dorsal skin of the mice was shaved with an electrical shaver at seven weeks of age; at this stage of growth, all of the hair follicles were synchronized in the telogen stage (Kim et al, 2014). Then, 0.05 mL of a 0.1% solution of polyphenol in 50% ethanol was applied and made fit in by spatula topically every day, for 35 days, and hair growth was evaluated.…”

Section: Investigation Of Hair Growth In Experimental Animalsmentioning

confidence: 99%

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Fisetin Promotes Hair Growth by Augmenting TERT Expression

Kubo

Ogawa

Uehara

et al. 2020

Front. Cell Dev. Biol.

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Although thinning hair and alopecia are not recognized as severe diseases, hair loss has implications for mental health and quality of life; therefore, a large number of studies have been carried out to develop novel hair growth agents. In the present study, we aimed to examine the potential of telomerase reverse transcriptase (TERT), because TERT overexpression in skin activates resting hair follicle bulge stem cells, which triggers initiation of a new hair follicle growth phase and promotes hair synthesis. To this end, we screened polyphenols that activate TERT expression in keratinocytes, and identified resveratrol and fisetin as strong hTERT-augmenting compounds. These polyphenols also regulated the gene expression of cytokines such as IGF-1 and KGF, which activate the β-catenin pathway, and TGF-β1, which plays an important role in maintaining the niche of hair follicle stem cells, thus are thought to play roles in promoting hair growth. We additionally showed that these polyphenols, especially fisetin, promoted hair growth from the shaved dorsal skin of mice, which suggests that these polyphenols activate the transition from telogen to anagen phase. Histological studies indicated that the dorsal skin of mice treated with these polyphenols contained numerous hair follicles and was thickened compared with that in control mice. Furthermore, on the dorsal skin of mice treated with resveratrol and fisetin, a number of proliferating cells (Ki67 + cells) were observed around the hair papilla. These results suggest that resveratrol and fisetin induce a shift from telogen to anagen in the hair follicle by inducing proliferation of hair follicle bulge stem cells, thus promoting hair growth.

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“…A human has about 100,000 follicles, which are small tissues that grow hair. The hairs growing from the follicles go through four hair cycles of anagen, catagen, telogen and exogen, repeating growth and alopecia (Fuchs, 2007;Kim et al, 2014). During the anagen phase of the skin, the follicles in the dermal papilla layer of the derma grow, which during the catagen phase, the thickness of the dermis decreases and the follicles get closer to the epidermis.…”

Section: Introductionmentioning

confidence: 99%

Action Mechanism of Natural Plant Extracts for Hair Loss Prevention and Hair Growth Promotion in C57BL/6 Mice

Park¹,

Park²,

Noh³

2015

International J. of Pharmacology

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The Natural Plant Extracts (NPE), produced by mixing seven natural plant extracts including sweet flag, contains asacurin 100 as its main ingredient and shows improvement in skin, but no hair growth effect has been reported. This study was conducted to evaluate the effects of NPE on mouse hair loss prevention and hair growth promotion and to determine the mechanism of action of NPE. Thirty male C57BL/6 mice were randomized into three treatment groups of 10 mice each: Control group (saline), NPE and minoxidil 5% application. For the NPE application group, the first hair growth was observed on day 9 and the density, length and thickness of their hair were significantly higher than those of the control group. Compared to the control group, the anagen hair growth in the C57BL/6 mice of the NPE application group was significantly stimulated. Compared to the control group, the expression of VEGF and KGF mRNA was up-regulated in the NPE and minoxidil 5% application groups, but the expression of TGF-β1 mRNA was down regulated on the contrary. This result suggests that NPE promotes hair growth while inducing anagen hair growth in animals through genetic regulation while, simultaneously preventing hair loss.

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Platycarya strobilacea S. et Z. Extract Has a High Antioxidant Capacity and Exhibits Hair Growth-promoting Effects in Male C57BL/6 Mice

Cited by 15 publications

References 29 publications

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Fisetin Promotes Hair Growth by Augmenting TERT Expression

Action Mechanism of Natural Plant Extracts for Hair Loss Prevention and Hair Growth Promotion in C57BL/6 Mice

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