Plazentalokalisation und Inzidenz der Präeklampsie

Gonser, M.; Tillack, N; Kh, Pfeiffer; G, Mielke

doi:10.1055/s-2007-1003188

Cited by 26 publications

(23 citation statements)

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“…This result is consistent with the studies by Tania K et al 5 Anuja VB et al 6 and Pai MV et al 7 Odds ratio in this study was 3.16 i.e., there is 3.16 times higher chances of development of preeclampsia among laterally located placenta than centrally located placenta. This finding is consistent with study by Anuja VB et al 6 Kofinas AD et al 8 and Gonser M et al 9 This is also comparable with the study by Tania K et al 5 and Seadati N et al 10 where the odds ratios were 5.09 and 5.6 respectively. In the present study, hypertension was mild in most of the cases (84.5%) ( Table 6) and both mild and severe form of hypertension are more common with laterally located placenta.…”

Section: Discussionsupporting

confidence: 91%

Study on Relation Between Placental Laterality in Second Trimester Ultrasound and Development of Preeclampsia at Term

Aggarwal¹,

Kangjam²,

Terhase³

2015

jemds

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OBJECTIVETo find whether placental laterality as determined by ultrasound can be used as predictor for the development of preeclampsia. METHODSThis prospective study was conducted on pregnant women attending the antenatal clinic of Regional Institute of Medical Sciences, Imphal, Manipur, from October 2012 till September 2014; 475 pregnant women attending antenatal clinic both OPD and IPD at 18-24 weeks of gestation without any high risk factor were subjected to ultrasound examination and placental location was determined. These cases were followed for the development of signs and symptoms of preeclampsia. RESULTOut of the total 475 women, 263(55.4%) had laterally located placenta and of them 45(17.1%) developed preeclampsia, while the remaining 212(44.6%) had centrally located placenta and of them 13(6.1%) developed preeclampsia. So, the overall risk of developing preeclampsia with laterally located placenta was 3.16 (odds ratio) and 95% confidence interval (1.65-6.03). The difference was found to be statistically significant, p value (0.0005) by χ 2 test. CONCLUSIONFrom the above study, we concluded that females with laterally located placenta determined by USG at 18-24 weeks of gestation have greater risk of developing preeclampsia. KEYWORDSPlacental laterality, Preeclampsia, Central placenta. HOW TO CITE THIS ARTICLE:Aggarwal P, Kangjam P, Terhase N. "Study on relation between placental laterality in second trimester ultrasound and development of preeclampsia at term

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Section: Discussionsupporting

confidence: 91%

Study on Relation Between Placental Laterality in Second Trimester Ultrasound and Development of Preeclampsia at Term

Aggarwal¹,

Kangjam²,

Terhase³

2015

jemds

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“…Hence, asymmetric blood flow may be related to regional heterogeneity in the transformation of spiral arteries into low-resistance vessels (17). Other investigators have shown that when the placenta is laterally placed, volumetric flow is higher and vascular impedance lower in the ipsilateral UA and that there is an increased incidence of PE, fetal distress, Cesarean sections, and IUGR (8,19,22). Because we did not observe differences in the location of the placenta among groups or any relationship between placental location and Q UA , we concluded that altered trophoblast invasion and remodeling rather than placenta location was responsible for the asymmetry observed.…”

Section: Discussionmentioning

confidence: 99%

High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude

Browne

Toledo-Jaldin

Dávila

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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The reduction in infant birth weight and increased frequency of preeclampsia (PE) in high-altitude residents have been attributed to greater placental hypoxia, smaller uterine artery (UA) diameter, and lower UA blood flow (Q(UA)). This cross-sectional case-control study determined UA, common iliac (CI), and external iliac (EI) arterial blood flow in Andeans residing at 3,600-4,100 m, who were either nonpregnant (NP, n = 23), or experiencing normotensive pregnancies (NORM; n = 155), preeclampsia (PE, n = 20), or gestational hypertension (GH, n = 12). Pregnancy enlarged UA diameter to ~0.62 cm in all groups, but indices of end-arteriolar vascular resistance were higher in PE or GH than in NORM. Q(UA) was lower in early-onset (≤34 wk) PE or GH than in NORM, but was normal in late-onset (>34 wk) illness. Left Q(UA) was consistently greater than right in NORM, but the pattern reversed in PE. Although Q(CI) and Q(EI) were higher in PE and GH than NORM, the fraction of Q(CI) distributed to the UA was reduced 2- to 3-fold. Women with early-onset PE delivered preterm, and 43% had stillborn small for gestational age (SGA) babies. Those with GH and late-onset PE delivered at term but had higher frequencies of SGA babies (GH=50%, PE=46% vs. NORM=15%, both P < 0.01). Birth weight was strongly associated with reduced Q(UA) (R(2) = 0.80, P < 0.01), as were disease severity and adverse fetal outcomes. We concluded that high end-arteriolar resistance, not smaller UA diameter, limited Q(UA) and restricted fetal growth in PE and GH. These are, to our knowledge, the first quantitative measurements of Q(UA) and pelvic blood flow in early- vs. late-onset PE in high-altitude residents.

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“…In addition, previous studies have revealed side-to-side differences in uteroplacental Doppler flow in pregnancies with unilateral placentas as well as the relationship between abnormal Doppler measurements and pre-eclampsia (13)(14)(15)(16)(17)(18)(19)(20)(21). However, reports on the direct association between placental location and development of pre-eclampsia, regardless of confounding factors (22), are limited.…”

Section: Introductionmentioning

confidence: 99%

Prediction of Pre-Eclampsia Development by Placenta Location: A Simple Predictor

Keshavarz

Sadeghian

Hakemi

et al. 2017

J Obstet Gynecol Cancer Res

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Background: Pre-eclampsia complicates 5% to 8% of all pregnancies and annual incidence of pre-eclampsia is about 5% of all pregnancies around the world and is a significant cause of both maternal and fetal mortality and morbidity if left untreated. Objectives: According to previous studies, blood supply distribution within the uterus is not similar in central compared with lateral sites, thus site of implantation and the resulting location of the placenta are likely to have a profound effect on the pregnancy outcome. Methods: The researchers conducted a case-control study over 1-year period at a referral obstetric hospital in the south of Tehran. Overall, 121 females with three degrees of pre-eclampsia were considered as cases and 258 females with normal pregnancy were the controls. The females were aged 20 to 40 years old and their gestational age was between 14 and 26 weeks. Results:The researchers recorded the participants' blood pressures and locations of placenta during this period with consideration of their past and present obstetric history as well as medical and familial history. As a result, pregnancies complicated by pre-eclampsia were more commonly associated with lateral placentation in the second trimester when compared with non-preeclampsia pregnancies. Discussion: This study suggests that placental location, which is easily assessed at middle trimester of pregnancy by routine screening ultrasonography, is an ideal predictive test for evaluating the risk of developing pre-eclampsia.

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Plazentalokalisation und Inzidenz der Präeklampsie

Abstract: These data suggest that a laterally located placenta is associated with a significantly increased incidence of preeclampsia, with a risk ratio of 3.1 when compared to pregnancies with centrally located placentas.

Cited by 26 publications

References 0 publications

Study on Relation Between Placental Laterality in Second Trimester Ultrasound and Development of Preeclampsia at Term

Study on Relation Between Placental Laterality in Second Trimester Ultrasound and Development of Preeclampsia at Term

High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude

Prediction of Pre-Eclampsia Development by Placenta Location: A Simple Predictor

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