OBJECTIVETo find whether placental laterality as determined by ultrasound can be used as predictor for the development of preeclampsia. METHODSThis prospective study was conducted on pregnant women attending the antenatal clinic of Regional Institute of Medical Sciences, Imphal, Manipur, from October 2012 till September 2014; 475 pregnant women attending antenatal clinic both OPD and IPD at 18-24 weeks of gestation without any high risk factor were subjected to ultrasound examination and placental location was determined. These cases were followed for the development of signs and symptoms of preeclampsia. RESULTOut of the total 475 women, 263(55.4%) had laterally located placenta and of them 45(17.1%) developed preeclampsia, while the remaining 212(44.6%) had centrally located placenta and of them 13(6.1%) developed preeclampsia. So, the overall risk of developing preeclampsia with laterally located placenta was 3.16 (odds ratio) and 95% confidence interval (1.65-6.03). The difference was found to be statistically significant, p value (0.0005) by χ 2 test. CONCLUSIONFrom the above study, we concluded that females with laterally located placenta determined by USG at 18-24 weeks of gestation have greater risk of developing preeclampsia. KEYWORDSPlacental laterality, Preeclampsia, Central placenta. HOW TO CITE THIS ARTICLE:Aggarwal P, Kangjam P, Terhase N. "Study on relation between placental laterality in second trimester ultrasound and development of preeclampsia at term

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OBJECTIVETo study the effect of Intrahepatic Cholestasis of Pregnancy on perinatal outcome with medical management and timely intervention in the form of induction of labour or Caesarean Section and its comparison with Control group. METHODSThis prospective study was conducted on pregnant women attending the Antenatal Clinic of Outpatient and Indoor Department of Obstetrics and Gynaecology of Maharaja Agrasen Hospital, Punjabi Bagh, New Delhi from August 2009 till July 2011; 50 Pregnant patients who developed pruritus during 2 nd and 3 rd trimester of pregnancy with or without jaundice and were having elevated total bile acids > 10 umol/L with or without deranged liver function tests were taken as cases and 50 Pregnant patients without ICP were taken as control. RESULTSIn our study, intrahepatic cholestasis was associated with:1. Increased incidence of intrapartum thick meconium staining of amniotic fluid (30% in Cases and 10% in Control). 2. The rate of induced delivery in the form of emergency caesarean section or induced labour was also high (34% in Cases and 14% in Control). 3. Increased incidence of low birth weight (<2500 gms) and low mean birth weight, i.e. 21.5% in Cases and 6% in Control group with active intervention at 37 weeks. CONCLUSIONFrom the above study we concluded that ICP is associated with increased rate of preterm delivery, caesarean sections, low birth weight babies and still birth. KEYWORDSICP, Meconium Staining, Preterm.HOW TO CITE THIS ARTICLE: Singla S, Aggarwal P, Mittal A. Study to show the effect of intrahepatic cholestasis of pregnancy on perinatal outcome in uncomplicated pregnancy.