Study to Show the Effect of Intrahepatic Cholestasis of Pregnancy on Perinatal Outcome in Uncomplicated Pregnancy

Abstract

OBJECTIVETo study the effect of Intrahepatic Cholestasis of Pregnancy on perinatal outcome with medical management and timely intervention in the form of induction of labour or Caesarean Section and its comparison with Control group. METHODSThis prospective study was conducted on pregnant women attending the Antenatal Clinic of Outpatient and Indoor Department of Obstetrics and Gynaecology of Maharaja Agrasen Hospital, Punjabi Bagh, New Delhi from August 2009 till July 2011; 50 Pregnant patients who developed pruritus during 2 nd and 3 rd trimester of pregnancy with or without jaundice and were having elevated total bile acids > 10 umol/L with or without deranged liver function tests were taken as cases and 50 Pregnant patients without ICP were taken as control. RESULTSIn our study, intrahepatic cholestasis was associated with:1. Increased incidence of intrapartum thick meconium staining of amniotic fluid (30% in Cases and 10% in Control). 2. The rate of induced delivery in the form of emergency caesarean section or induced labour was also high (34% in Cases and 14% in Control). 3. Increased incidence of low birth weight (<2500 gms) and low mean birth weight, i.e. 21.5% in Cases and 6% in Control group with active intervention at 37 weeks. CONCLUSIONFrom the above study we concluded that ICP is associated with increased rate of preterm delivery, caesarean sections, low birth weight babies and still birth. KEYWORDSICP, Meconium Staining, Preterm.HOW TO CITE THIS ARTICLE: Singla S, Aggarwal P, Mittal A. Study to show the effect of intrahepatic cholestasis of pregnancy on perinatal outcome in uncomplicated pregnancy.